Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gastric carcinoma cell | expression analysis of ppGalNAc-T6 in gastric mucosa, intestinal metaplasia, and gastric carcinomas, the isozyme shows a heterogeneous expression and staining pattern | Homo sapiens | - |
stomach | expression analysis of ppGalNAc-T6 in gastric mucosa, intestinal metaplasia, and gastric carcinomas | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ppGalNAc-T6 | - |
Homo sapiens |
UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | aberrant mucin O-glycosylation is often observed in cancer and is characterized by the expression of immature simple mucin-type carbohydrate antigens. Altered expression of ppGalNAc-Ts can be one of the mechanisms that explain the changes in mucin O-glycosylation during malignant transformation | Homo sapiens |
physiological function | ppGalNAc-T6 is one of the enzymes responsible for the initial step in mucin O-glycosylation | Homo sapiens |