Reference on EC 2.3.1.21 - carnitine O-palmitoyltransferase and Organism(s) Rattus norvegicus and UniProt Accession P18886
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Morillas, M.; Gomez-Puertas, P.; Roca, R.; Serra, D.; Asins, G.; Valencia, A.; Hegardt, F.G.
Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT). Mutation of CPT 1 histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity
J. Biol. Chem.
276
45001-45008
2001
Rattus norvegicus
Sekas, G.; Paul, H.S.
Inhibition of carnitine acyltransferase activities by bile acids in rat liver peroxisomes
Biochim. Biophys. Acta
1125
396-402
1992
Rattus norvegicus
-
Miyazawa, S.; Ozaka, H.; Osumi, T.; Hashiomoto, T.
Purification and properties of carnitine octanoyltransferase and carnitine palmitoyltransferase from rat liver
J. Biochem.
94
529-542
1983
Rattus norvegicus
Murthy, M.S.R.; Pande, S.V.
Some differences in the properties of carnitine palmitoyltransferase activities of the mitochondrial outer and inner membranes
Biochem. J.
248
727-733
1987
Rattus norvegicus
Murthy, M.S.R.; Pande, S.V.
Characterization of a solubilized malonyl-CoA-sensitive carnitine palmitoyltransferase from the mitochondrial outer membrane as a protein distinct from the malonyl-CoA-insensitive carnitine palmitoyltransferase of the inner membrane
Biochem. J.
268
599-604
1990
Rattus norvegicus
Halperin, M.L.; Pande, S.V.
Fatty acyl group transport into mitochondria: carnitine palmitoyl transferases EC 2.3.1.23 and the carnitine-acylcarnitine translocase
Methods Enzymol.
56
368-378
1979
Bos taurus, Rattus norvegicus
Kolodziej, M.P.; Zammit, V.A.
Sensitivity of inhibition of rat liver mitochondrial outer-membrane carnitine palmitoyltransferase by malonyl-CoA to chemical- and temperature-induced changes in membrane fluidity
Biochem. J.
272
421-425
1990
Rattus norvegicus
Woeltje, K.F.; Esser, V.; Weis, B.C.; Sen, A.; Cox, W.F.; McPaul, M.J.; Slaughter, C.A.; Foster, D.W.; McGarry, J.D.
Cloning, sequencing, and expression of a cDNA encoding rat liver mitochondrial carnitine palmitoyltransferase II
J. Biol. Chem.
265
10720-10725
1990
Rattus norvegicus
Chung, C.H.; Woldegiorgis, G.; Dai, G.; Shrago, E.; Bieber, L.L.
Conferral of malonyl coenzyme A sensitivity to purified rat heart mitochondrial carnitine palmitoyltransferase
Biochemistry
31
9777-9783
1992
Rattus norvegicus
Ghadiminejad, I.; Saggerson, E.D.
Carnitine palmitoyltransferase (CPT2) from liver mitochondrial inner membrane becomes inhibitable by malonyl-CoA if reconstituted with outer membrane malonyl-CoA binding protein
FEBS Lett.
269
406-408
1990
Rattus norvegicus
Gavino, G.R.; Gavino, V.C.
Rat liver outer mitochondrial carnitine palmitoyltransferase activity towards long-chain polyunsaturated fatty acids and their CoA esters
Lipids
26
266-270
1991
Rattus norvegicus
Woldegiorgis, G.; Fibich, B.; Contreras, L.; Shrago, E.
Restoration of malonyl-CoA sensitivity of soluble rat liver mitochondria carnitine palmitoyltransferase by reconstitution with a partially purified malonyl-CoA binding protein
Arch. Biochem. Biophys.
295
348-351
1992
Rattus norvegicus
Ghadiminejad, I.; Saggerson, D.
A simple method for the purification of carnitine palmitoyl transferase 2 from rat liver
Biochem. Soc. Trans.
17
348-349
1989
Rattus norvegicus
-
Murthy, M.S.R.; Ramsay, R.R.; Pande, S.V.
Carnitine analogues and carnitine palmitoyltransferases
Biochem. Soc. Trans.
18
604-605
1990
Rattus norvegicus
Gandour, R.D.; Colucci, W.J.; Stelly, T.C.; Brady, P.S.; Brady, L.J.
Hemipalmitoylcarnitinium, a strong competitive inhibitor of purified hepatic carnitine palmitoyltransferase
Arch. Biochem. Biophys.
267
515-520
1988
Rattus norvegicus
Kashfi, K.; Cook, G.A.
Malonyl-CoA inhibits proteolysis of carnitine palmitoyltransferase
Biochem. Biophys. Res. Commun.
178
600-605
1991
Rattus norvegicus
Brindle, N.P.J.; Zammit, V.A.; Pogson, C.I.
Regulation of carnitine palmitoyltransferase activity by malonyl-CoA in mitochondria from sheep liver, a tissue with a low capacity for fatty acid synthesis
Biochem. J.
232
177-182
1985
Cavia porcellus, Ovis aries, Rattus norvegicus
Brady, P.S.; Dunker, A.K.; Brady, L.J.
Characterization of hepatic carnitine palmitoyltransferase. Use of bromoacyl derivatives and antibodies
Biochem. J.
241
751-757
1987
Rattus norvegicus
Bartlett, K.; Sherratt, H.S.A.; Turnbull, D.M.
Inhibition of hepatic and skeletal muscle carnitine palmitoyltransferase I by 2[5(4-chlorophenyl)pentyl]-oxirane-2-carbonyl-CoA
Biochem. Soc. Trans.
12
688-689
1984
Rattus norvegicus
-
Cook, G.A.
Differences in the sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA are due to differences in Ki values
J. Biol. Chem.
259
12030-12033
1984
Rattus norvegicus
Brosnan, J.T.; Kopec, B.; Fritz, I.B.
The localization of carnitine palmitoyltransferase on the inner membrane of bovine liver mitochondria
J. Biol. Chem.
248
4075-4082
1973
Bos taurus, Rattus norvegicus
Paulson, D.J.; Ward, K.M.; Shug, A.L.
Malonyl CoA inhibition of carnitine palmityltransferase in rat heart mitochondria
FEBS Lett.
176
381-384
1984
Rattus norvegicus
Pande, S.V.; Murthy, M.S.R.; Noel, H.
Differential effects of phosphatidylcholine and cardiolipin on carnitine palmitoyltransferase activity
Biochim. Biophys. Acta
877
223-230
1986
Rattus norvegicus
Saggerson, E.D.; Carpenter, C.A.
Sensitivity of brown-adipose-tissue carnitine palmitoyltransferase to inhibition by malonyl-CoA
Biochem. J.
204
373-375
1982
Rattus norvegicus
Stephens, T.W.; Cook, G.A.; Harris, R.A.
Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I
Biochem. J.
212
521-524
1983
Rattus norvegicus
McCormick, K.; Notar-Francesco, V.J.
Importance of albumin binding in the assay for carnitine palmitoyltransferase
Biochem. J.
216
495-498
1983
Rattus norvegicus
McCormick, K.; Notar-Francesco, V.J.; Sriwatanakul, K.
Inhibition by acetyl-CoA of hepatic carnitine acyltransferase and fatty acid oxidation
Biochem. J.
216
499-502
1983
Rattus norvegicus
Bergstrom, J.D.; Reitz, R.C.
Studies on carnitine palmitoyl transferase: the similar nature of CPTi (inner form) and CPTo (outer form)
Arch. Biochem. Biophys.
204
71-79
1980
Rattus norvegicus
Declercq, P.E.; Falck, J.R.; Kuwajima, M.; Tyminski, H.; Foster, D.W.; McGarry, J.D.
Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. I. Use of inhibitors
J. Biol. Chem.
262
9812-9821
1987
Rattus norvegicus
Woeltje, K.F.; Esser, V.; Weis, B.C.; Cox, W.F.; Schroeder, J.G.; Liao, S.L.; Foster, D.W.; McGarry, J.D.
Inter-tissue and inter-species characteristics of the mitochondrial carnitine palmitoyltransferase enzyme system
J. Biol. Chem.
265
10714-10719
1990
Homo sapiens, Platyrrhini, Mus musculus, Rattus norvegicus
Lund, H.
Carnitine palmitoyltransferase: characterization of a labile detergent-extracted malonyl-CoA-sensitive enzyme from rat liver mitochondria
Biochim. Biophys. Acta
918
67-75
1987
Rattus norvegicus
Kopec, B.; Fritz, I.B.
Comparison of properties of carnitine palmitoyltransferase I with those of carnitine palmitoyltransferase II, and preparation of antibodies to carnitine palmitoyltransferases
J. Biol. Chem.
248
4069-4074
1973
Rattus norvegicus
Woldegiorgis, G.; Bremer, J.; Shrago, E.
Substrate inhibition of carnitine palmitoyltransferase by palmitoyl-CoA and activation by phospholipids and proteins
Biochim. Biophys. Acta
837
135-140
1985
Rattus norvegicus
Weis, B.C.; Cowan, A.T.; Brown, N.; Foster, D.W.; McGarry, J.D.
Use of a selective inhibitor of liver carnitine palmitoyltransferase I (CPT I) allows quantification of its contribution to total CPT I activity in rat heart. Evidence that the dominant cardiac CPT I isoform is identical to the skeletal muscle enzyme
J. Biol. Chem.
269
26443-26448
1994
Rattus norvegicus
Kashfi, K.; Mynatt, R.L.; Cook, G.A.
Hepatic carnitine palmitoyltransferase-I has two independent inhibitory binding sites for regulation of fatty acid oxidation
Biochim. Biophys. Acta
1212
245-252
1994
Rattus norvegicus
Singh, H.; Poulos, A.
Substrate specificity of rat liver mitochondrial carnitine palmitoyl transferase I: evidence against alpha-oxidation of phytanic acid in rat liver mitochondria
FEBS Lett.
359
179-183
1995
Rattus norvegicus
Johnson, T.M.; Mann, W.R.; Dragland, C.J.; Anderson, R.C.; Nemecek, G.M.; Bell, P.A.
Over-expression and characterization of active recombinant rat liver carnitine palmitoyltransferase II using baculovirus
Biochem. J.
309
689-693
1995
Rattus norvegicus
-
De Vries, Y.; Arvidson, D.N.; Waterham, H.R.; Cregg, J.M.; Woldegiorgis, G.
Functional characterization of mitochondrial carnitine palmitoyltransferases I and II expressed in the yeast Pichia pastoris
Biochemistry
36
5285-5292
1997
no activity in Pichia pastoris, Rattus norvegicus
Brown, N.F.; Hill, J.K.; Esser, V.; Kirkland, J.L.; Corkey, B.E.; Foster, D.W.; McGarry, J.D.
Mouse white adipocytes and 3T3-L1 cells display an anomalous pattern of carnitine palmitoyltransferase (CPT) I isoform expression during differentiation. Inter-tissue and inter-species expression of CPT I and CPT II enzymes
Biochem. J.
327
225-231
1997
Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus
-
Prip-Buus, C.; Cohen, I.; Kohl, C.; Esser, V.; McGarry, J.D.; Girard, J.
Topological and functional analysis of the rat liver carnitine palmitoyltransferase 1 expressed in Saccharomyces cerevisiae
FEBS Lett.
429
173-178
1998
Rattus norvegicus
Jackson, V.N.; Cameron, J.M.; Fraser, F.; Zammit, V.A.; Price, N.T.
Use of six chimeric proteins to investigate the role of intramolecular interactions in determining the kinetics of carnitine palmitoyltransferase I isoforms
J. Biol. Chem.
275
19560-19566
2000
Rattus norvegicus
Eaton, S.; Fukumoto, K.; Paladio Duran, N.; Pierro, A.; Spitz, L.; Quant, P.A.; Bartlett, K.
Carnitine palmitoyl transferase I and the control of myocardial beta-oxidation flux
Biochem. Soc. Trans.
29
245-250
2001
Homo sapiens, Rattus norvegicus
Abo-Hashema, K.A.H.; Cake, M.H.; Lukas, M.A.; Knudsen, J.
The interaction of acyl-CoA with acyl-CoA binding protein and carnitine palmitoyltransferase I
Int. J. Biochem. Cell Biol.
33
807-815
2001
Rattus norvegicus
Colquhoun, A.
Gamma-linolenic acid alters the composition of mitochondrial membrane subfractions, decreases outer mitochondrial membrane binding of hexokinase and alters carnitine palmitoyltransferase I properties in the Walker 256 rat tumour
Biochim. Biophys. Acta
1583
74-84
2002
Rattus norvegicus
Nicot, C.; Relat, J.; Woldegiorgis, G.; Haro, D.; Marrero, P.F.
Pig liver carnitine palmitoyltransferase: chimera studies show that both the N- and C-terminal regions of the enzyme are important for the unusual high malonyl-CoA sensitivity
J. Biol. Chem.
277
10044-10049
2002
Rattus norvegicus, Sus scrofa
McGarry, J.D.; Brown, N.F.
Reconstitution of purified, active and malonyl-CoA-sensitive rat liver carnitine palmitoyltransferase I: relationship between membrane environment and malonyl-CoA sensitivity
Biochem. J.
349
179-187
2000
Rattus norvegicus
Broadway, N.M.; Pease, R.J.; Birdsey, G.; Shayeghi, M.; Turner, N.A.; David Saggerson, E.
The liver isoform of carnitine palmitoyltransferase 1 is not targeted to the endoplasmic reticulum
Biochem. J.
370
223-231
2003
Rattus norvegicus
Napal, L.; Dai, J.; Treber, M.; Haro, D.; Marrero, P.F.; Woldegiorgis, G.
A single amino acid change (substitution of the conserved Glu-590 with alanine) in the C-terminal domain of rat liver carnitine palmitoyltransferase I increases its malonyl-CoA sensitivity close to that observed with the muscle isoform of the enzyme
J. Biol. Chem.
278
34084-34089
2003
Rattus norvegicus (P32198)
Morillas, M.; Gomez-Puertas, P.; Bentebibel, A.; Selles, E.; Casals, N.; Valencia, A.; Hegardt, F.G.; Asins, G.; Serra, D.
Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition
J. Biol. Chem.
278
9058-9063
2003
Rattus norvegicus (P32198)
Kerner, J.; Distler, A.M.; Minkler, P.; Parland, W.; Peterman, S.M.; Hoppel, C.L.
Phosphorylation of rat liver mitochondrial carnitine palmitoyltransferase-I: effect on the kinetic properties of the enzyme
J. Biol. Chem.
279
41104-41113
2004
Rattus norvegicus (P32198)
Bentebibel, A.; Sebastian, D.; Herrero, L.; Lopez-Vinas, E.; Serra, D.; Asins, G.; Gomez-Puertas, P.; Hegardt, F.G.
Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation
Biochemistry
45
4339-4350
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Kuhajda, F.P.; Ronnett, G.V.
Modulation of carnitine palmitoyltransferase-1 for the treatment of obesity
Curr. Opin. Investig. Drugs
8
312-317
2007
Homo sapiens, Rattus norvegicus
Doh, K.O.; Kim, Y.W.; Park, S.Y.; Lee, S.K.; Park, J.S.; Kim, J.Y.
Interrelation between long-chain fatty acid oxidation rate and carnitine palmitoyltransferase 1 activity with different isoforms in rat tissues
Life Sci.
77
435-443
2005
Rattus norvegicus
Stefanovic-Racic, M.; Perdomo, G.; Mantell, B.S.; Sipula, I.J.; Brown, N.F.; ODoherty, R.M.
A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels
Am. J. Physiol. Endocrinol. Metab.
294
E969-E977
2008
Rattus norvegicus (P18886), Rattus norvegicus (P32198)
Sorokina, N.; ODonnell, J.M.; McKinney, R.D.; Pound, K.M.; Woldegiorgis, G.; LaNoue, K.F.; Ballal, K.; Taegtmeyer, H.; Buttrick, P.M.; Lewandowski, E.D.
Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts
Circulation
115
2033-2041
2007
Rattus norvegicus
Okere, I.C.; Chandler, M.P.; McElfresh, T.A.; Rennison, J.H.; Kung, T.A.; Hoit, B.D.; Ernsberger, P.; Young, M.E.; Stanley, W.C.
Carnitine palmitoyl transferase-I inhibition is not associated with cardiac hypertrophy in rats fed a high-fat diet
Clin. Exp. Pharmacol. Physiol.
34
113-119
2007
Rattus norvegicus
Sierra, A.Y.; Gratacos, E.; Carrasco, P.; Clotet, J.; Urena, J.; Serra, D.; Asins, G.; Hegardt, F.G.; Casals, N.
CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity
J. Biol. Chem.
283
6878-6885
2008
Rattus norvegicus
Kuroda, T.; Hirota, H.; Fujio, Y.; Sugiyama, S.; Masaki, M.; Hiramoto, Y.; Shioyama, W.; Okamoto, K.; Hori, M.; Yamauchi-Takihara, K.
Carbacyclin induces carnitine palmitoyltransferase-1 in cardiomyocytes via peroxisome proliferator-activated receptor (PPAR) delta independent of the IP receptor signaling pathway
J. Mol. Cell. Cardiol.
43
54-62
2007
Mus musculus, Rattus norvegicus
Sadana, P.; Zhang, Y.; Song, S.; Cook, G.A.; Elam, M.B.; Park, E.A.
Regulation of carnitine palmitoyltransferase I (CPT-Ialpha) gene expression by the peroxisome proliferator activated receptor gamma coactivator (PGC-1) isoforms
Mol. Cell. Endocrinol.
267
6-16
2007
Rattus norvegicus
Akkaoui, M.; Cohen, I.; Esnous, C.; Lenoir, V.; Sournac, M.; Girard, J.; Prip-Buus, C.
Modulation of the hepatic malonyl-CoA-carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids
Biochem. J.
420
429-438
2009
Rattus norvegicus
Rufer, A.C.; Thoma, R.; Hennig, M.
Structural insight into function and regulation of carnitine palmitoyltransferase
Cell. Mol. Life Sci.
66
2489-2501
2009
Rattus norvegicus
Roomets, E.; Kivelae, T.; Tyni, T.
Carnitine palmitoyltransferase I and Acyl-CoA dehydrogenase 9 in retina: insights of retinopathy in mitochondrial trifunctional protein defects
Invest. Ophthalmol. Vis. Sci.
49
1660-1664
2008
Homo sapiens, Rattus norvegicus
Zammit, V.
Carnitine palmitoyltransferase 1: central to cell function
IUBMB Life
60
347-354
2008
Rattus norvegicus
Bi, Y.; Cai, M.; Liang, H.; Sun, W.; Li, X.; Wang, C.; Zhu, Y.; Chen, X.; Li, M.; Weng, J.
Increased carnitine palmitoyl transferase 1 expression and decreased sterol regulatory element-binding protein 1c expression are associated with reduced intramuscular triglyceride accumulation after insulin therapy in high-fat-diet and streptozotocin-indu
Metab. Clin. Exp.
58
779-786
2009
Rattus norvegicus
Sharma, V.; Abraham, T.; So, A.; Allard, M.; McNeill, J.
Functional effects of protein kinases and peroxynitrite on cardiac carnitine palmitoyltransferase-1 in isolated mitochondria
Mol. Cell. Biochem.
337
223-237
2010
Rattus norvegicus
Lee, K.; Kerner, J.; Hoppel, C.L.
Mitochondrial carnitine palmitoyltransferase 1a (CPT1a) is part of an outer membrane fatty acid transfer complex
J. Biol. Chem.
286
25655-25662
2011
Rattus norvegicus (P32198)
Hostetler, H.A.; Lupas, D.; Tan, Y.; Dai, J.; Kelzer, M.S.; Martin, G.G.; Woldegiorgis, G.; Kier, A.B.; Schroeder, F.
Acyl-CoA binding proteins interact with the acyl-CoA binding domain of mitochondrial carnitine palmitoyl transferase I
Mol. Cell. Biochem.
355
135-148
2011
Rattus norvegicus (P32198)
Hada, T.; Kato, Y.; Obana, E.; Yamamoto, A.; Yamazaki, N.; Hashimoto, M.; Yamamoto, T.; Shinohara, Y.
Comparison of two expression systems using COS7 cells and yeast cells for expression of heart/muscle-type carnitine palmitoyltransferase 1
Protein Expr. Purif.
82
192-196
2012
Rattus norvegicus (Q63704)
Hada, T.; Yamamoto, T.; Yamamoto, A.; Ohkura, K.; Yamazaki, N.; Takiguchi, Y.; Shinohara, Y.
Comparison of the catalytic activities of three isozymes of carnitine palmitoyltransferase 1 expressed in COS7 cells
Appl. Biochem. Biotechnol.
172
1486-1496
2014
Rattus norvegicus
Console, L.; Giangregorio, N.; Indiveri, C.; Tonazzi, A.
Carnitine/acylcarnitine translocase and carnitine palmitoyltransferase 2 form a complex in the inner mitochondrial membrane
Mol. Cell. Biochem.
394
307-314
2014
Rattus norvegicus
