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Literature summary for 2.3.1.21 extracted from

  • Brindle, N.P.J.; Zammit, V.A.; Pogson, C.I.
    Regulation of carnitine palmitoyltransferase activity by malonyl-CoA in mitochondria from sheep liver, a tissue with a low capacity for fatty acid synthesis (1985), Biochem. J., 232, 177-182.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.21

Inhibitors

Inhibitors Comment Organism Structure
malonyl-CoA CPT I Cavia porcellus
malonyl-CoA CPT I; regulatory role in vivo Ovis aries
malonyl-CoA CPT I; regulatory role in vivo Rattus norvegicus
methylmalonyl-CoA inhibits sheep liver CPT I, no inhibition of rat liver and guinea-pig liver mitochondrial CPT I Cavia porcellus
methylmalonyl-CoA inhibits sheep liver CPT I, no inhibition of rat liver and guinea-pig liver mitochondrial CPT I Ovis aries
methylmalonyl-CoA inhibits sheep liver CPT I, no inhibition of rat liver and guinea-pig liver mitochondrial CPT I Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane inner face of inner membrane Cavia porcellus 5743
-
mitochondrial inner membrane inner face of inner membrane Rattus norvegicus 5743
-
mitochondrial inner membrane inner face of inner membrane Ovis aries 5743
-
mitochondrion
-
 Cavia porcellus 5739
-
mitochondrion
-
 Rattus norvegicus 5739
-
mitochondrion
-
 Ovis aries 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + L-carnitine Cavia porcellus
-
 CoA + L-acylcarnitine
-
 ?
acyl-CoA + L-carnitine Rattus norvegicus
-
 CoA + L-acylcarnitine
-
 ?
acyl-CoA + L-carnitine Ovis aries
-
 CoA + L-acylcarnitine
-
 ?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-
Ovis aries
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Cavia porcellus
-
liver
-
 Rattus norvegicus
-
liver
-
 Ovis aries
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + L-carnitine
-
 Cavia porcellus CoA + L-acylcarnitine
-
 ?
acyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-acylcarnitine
-
 ?
acyl-CoA + L-carnitine
-
 Ovis aries CoA + L-acylcarnitine
-
 ?