Activating Compound | Comment | Organism | Structure |
---|---|---|---|
C-75 | i.e. 3-carboxy-4-alkyl-2-methylenebutyrolactone, physiologic enzyme stimulation, regulatory effects, overview | Homo sapiens | |
C-75 | i.e. 3-carboxy-4-alkyl-2-methylenebutyrolactone, physiologic enzyme stimulation, the stimulation reduces food consumption and weight, regulatory effects, overview | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | enzyme inhibitors are used to shift the heart's reliance away from fatty acid oxidation to glucose as energy source to increase cardiac efficiency, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
etomoxir | - |
Homo sapiens | |
malonyl-CoA | has a regulatory role in vivo | Homo sapiens | |
malonyl-CoA | has a regulatory role in vivo | Rattus norvegicus | |
additional information | enzyme inhibitors are used to shift the heart's reliance away from fatty acid oxidation to glucose as energy source to increase cardiac efficiency, overview | Homo sapiens | |
oxfenicine | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial outer membrane | - |
Homo sapiens | 5741 | - |
mitochondrial outer membrane | - |
Rattus norvegicus | 5741 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
88200 | - |
x * 88200, isozymes L-CPT1 and M-CPT1 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | the enzyme is rate-limiting in the mitochondrial fatty axid oxidation pathway, physiologic regulation, inhibition of fatty acid oxidation increases food intake, overview | ? | - |
? | |
additional information | Homo sapiens | the enzyme is rate-limiting in the mitochondrial fatty axid oxidation pathway, physiologic regulation, overview | ? | - |
? | |
palmitoyl-CoA + L-carnitine | Homo sapiens | - |
CoA + L-palmitoylcarnitine | - |
? | |
palmitoyl-CoA + L-carnitine | Rattus norvegicus | - |
CoA + L-palmitoylcarnitine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes L-CPT1 and M-CPT1 | - |
Rattus norvegicus | - |
isozymes L-CPT1 and M-CPT1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | isozyme L-CPT-1 | Homo sapiens | - |
liver | isozyme L-CPT-1 | Rattus norvegicus | - |
muscle | isozyme M-CPT-1 | Homo sapiens | - |
muscle | isozyme M-CPT-1 | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is rate-limiting in the mitochondrial fatty axid oxidation pathway, physiologic regulation, inhibition of fatty acid oxidation increases food intake, overview | Rattus norvegicus | ? | - |
? | |
additional information | the enzyme is rate-limiting in the mitochondrial fatty axid oxidation pathway, physiologic regulation, overview | Homo sapiens | ? | - |
? | |
palmitoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-palmitoylcarnitine | - |
? | |
palmitoyl-CoA + L-carnitine | - |
Rattus norvegicus | CoA + L-palmitoylcarnitine | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 88200, isozymes L-CPT1 and M-CPT1 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
carnitine palmitoyltransferase-1 | - |
Homo sapiens |
carnitine palmitoyltransferase-1 | - |
Rattus norvegicus |
CPT-1 | - |
Homo sapiens |
CPT-1 | - |
Rattus norvegicus |