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Literature summary for 2.3.1.21 extracted from

  • Brown, N.F.; Hill, J.K.; Esser, V.; Kirkland, J.L.; Corkey, B.E.; Foster, D.W.; McGarry, J.D.
    Mouse white adipocytes and 3T3-L1 cells display an anomalous pattern of carnitine palmitoyltransferase (CPT) I isoform expression during differentiation. Inter-tissue and inter-species expression of CPT I and CPT II enzymes (1997), Biochem. J., 327, 225-231.
No PubMed abstract available
Search for more literature for 2.3.1.21

Inhibitors

Inhibitors Comment Organism Structure
malonyl-CoA CPT I; isoforms L-CPT I and M-CPT I Homo sapiens
malonyl-CoA CPT I; isoforms L-CPT I and M-CPT I Mus musculus
malonyl-CoA CPT I; isoforms L-CPT I and M-CPT I Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial outer membrane CPT I is located in the outer membrane Mus musculus 5741
-
mitochondrial outer membrane CPT I is located in the outer membrane Rattus norvegicus 5741
-
mitochondrion 2 isoforms of CPT I, L-CPT I and M-CPT I Mus musculus 5739
-
mitochondrion 2 isoforms of CPT I, L-CPT I and M-CPT I Homo sapiens 5739
-
mitochondrion 2 isoforms of CPT I, L-CPT I and M-CPT I Rattus norvegicus 5739
-
mitochondrion 2 isoforms of CPT I, L-CPT I and M-CPT I Mesocricetus auratus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + L-carnitine Homo sapiens
-
 CoA + L-acylcarnitine
-
 ?
acyl-CoA + L-carnitine Mesocricetus auratus
-
 CoA + L-acylcarnitine
-
 ?
acyl-CoA + L-carnitine Mus musculus CPT I, involved in regulation of fatty acid oxidation CoA + L-acylcarnitine
-
 ?
acyl-CoA + L-carnitine Rattus norvegicus CPT I, involved in regulation of fatty acid oxidation CoA + L-acylcarnitine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 2 isoforms M-CPT I and L-CPT I
-
Mesocricetus auratus
-
 2 isoforms L-CPT I and M-CPT I
-
Mus musculus
-
 2 isoforms L-CPT I and M-CPT I
-
Rattus norvegicus
-
 2 isoforms L-CPT I and M-CPT I
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell CPT I and CPT II Mus musculus
-
adipocyte
-
 Mus musculus
-
adipocyte
-
 Homo sapiens
-
adipocyte
-
 Rattus norvegicus
-
adipocyte
-
 Mesocricetus auratus
-
brain low content L-CPT I and CPT II Rattus norvegicus
-
brown adipose tissue CPT II, M-CPT I Mesocricetus auratus
-
brown adipose tissue CPT II, M-CPT I, L-CPT I Mus musculus
-
brown adipose tissue CPT II, M-CPT I, L-CPT I Rattus norvegicus
-
heart
-
 Mus musculus
-
heart CPT II, M-CPT I and low content of L-CPT I Homo sapiens
-
heart CPT II, M-CPT I and low content of L-CPT I Rattus norvegicus
-
intestine small and large, L-CPT I and CPT II Rattus norvegicus
-
kidney cortex and medulla, L-CPT I and CPT II Rattus norvegicus
-
liver
-
 Mus musculus
-
liver
-
 Homo sapiens
-
liver L-CPT I Rattus norvegicus
-
lung low content L-CPT I and CPT II Rattus norvegicus
-
additional information not in spleen Rattus norvegicus
-
ovary low content of M-CPT I, and higher content of CPT II ad L-CPT I Rattus norvegicus
-
pancreatic islet low content of CPT II, no CPT I Rattus norvegicus
-
skeletal muscle
-
 Mus musculus
-
skeletal muscle M-CPT I Rattus norvegicus
-
skeletal muscle CPT II Homo sapiens
-
skeletal muscle CPT II Rattus norvegicus
-
testis L-CPT I and high content of CPT II and M-CPT I Rattus norvegicus
-
white adipose tissue CPT II, M-CPT I Homo sapiens
-
white adipose tissue CPT II, M-CPT I, L-CPT I Rattus norvegicus
-
white adipose tissue CPT II, M-CPT I, L-CPT I Mesocricetus auratus
-
white adipose tissue CPT II, L-CPT I Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0013
-
-
 Rattus norvegicus
0.0013
-
 cell line 3T3-L1, CPT I, 6 days after differentiation Mus musculus
0.0062
-
 cell line 3T3-L1, CPT II, 6 days after differentiation Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + L-carnitine
-
 Mus musculus CoA + L-acylcarnitine
-
 ?
acyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-acylcarnitine
-
 ?
acyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-acylcarnitine
-
 ?
acyl-CoA + L-carnitine
-
 Mesocricetus auratus CoA + L-acylcarnitine
-
 ?
acyl-CoA + L-carnitine CPT I, involved in regulation of fatty acid oxidation Mus musculus CoA + L-acylcarnitine
-
 ?
acyl-CoA + L-carnitine CPT I, involved in regulation of fatty acid oxidation Rattus norvegicus CoA + L-acylcarnitine
-
 ?