6.3.5.6: asparaginyl-tRNA synthase (glutamine-hydrolysing)
This is an abbreviated version!
For detailed information about asparaginyl-tRNA synthase (glutamine-hydrolysing), go to the full flat file.
Word Map on EC 6.3.5.6
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6.3.5.6
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gln-trnagln
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transamidation
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asn-trnaasn
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aminoacyl-trnas
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asparagine
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mischarged
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glutaminyl-trna
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aminoacylation
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archaea
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heterotrimeric
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synthetases
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nondiscriminating
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misacylated
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helicobacter
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gatde
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transamidosome
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nd-asprs
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glutamyl-trnagln
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pylori
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glutaminase
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thermautotrophicus
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transamidase
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asparaginylation
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gln-trna
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trnaglu
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deinococcus
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radiodurans
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glutaminylated
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methanothermobacter
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mistranslation
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trnaasp
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anticodon-binding
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d-loop
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pharmacology
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biotechnology
- 6.3.5.6
- gln-trnagln
-
transamidation
- asn-trnaasn
- aminoacyl-trnas
- asparagine
-
mischarged
- glutaminyl-trna
- aminoacylation
- archaea
-
heterotrimeric
- synthetases
-
nondiscriminating
-
misacylated
-
helicobacter
- gatde
-
transamidosome
- nd-asprs
- glutamyl-trnagln
- pylori
- glutaminase
- thermautotrophicus
-
transamidase
-
asparaginylation
-
gln-trna
- trnaglu
- deinococcus
- radiodurans
-
glutaminylated
-
methanothermobacter
-
mistranslation
- trnaasp
-
anticodon-binding
-
d-loop
- pharmacology
- biotechnology
Reaction
Synonyms
AdT, AsnRS, Asp-AdT, Asp-tRNAAsn amidotransferase, Asp/Glu-Adt, asparaginyl-transfer RNA synthetase, Asparaginyl-tRNA synthetase, aspartyl-tRNAAsn amidotransferase, GatCAB, glutamine-dependent Asp-tRNAAsn/Glu-tRNAGln amidotransferase, NRS, tRNA-dependent amidotransferase
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 6.3.5.6 - asparaginyl-tRNA synthase (glutamine-hydrolysing)
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REACTION DIAGRAM
ATP + Asp-tRNAAsn + L-glutamine + H2O
ADP + phosphate + Asn-tRNAAsn + L-glutamate
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-
-
-
?
ATP + L-aspartyl-tRNAAsn + L-glutamine
ADP + phosphate + L-asparaginyl-tRNAAsn + L-glutamate
Asn-tRNAAsn + ?
-
tRNA-dependent transamidation pathway of Asn-tRNA formation, which is required for protein synthesis or under certain metabolic situations for asparagine synthesis
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
-
it is likely that the dual specificity amidotransferase serves in Asn-tRNA and Gln-tRNA formation in vivo
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
-
it is likely that the dual specificity amidotransferase serves in Asn-tRNA and Gln-tRNA formation in vivo
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
-
AdT is related to the biosynthesis of asparagine rather than to provide charged tRNA for protein biosynthesis
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
-
tRNA-dependent transamidation pathway of Asn-tRNA formation, only biosynthetic route to asparagine is via Asn-tRNA
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
-
tRNA-dependent transamidation pathway of Asn-tRNA formation, only biosynthetic route to asparagine is via Asn-tRNA
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
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gatCAB genes encoded Asp-AdT may be responsible for biosynthesis of asparagine, glutamine as amide source
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?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
-
in vivo only Asn-tRNAAsn formation occurs
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
-
in vivo only Asn-tRNAAsn formation occurs
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
-
enzyme of the two-step pathway for the synthesis of Asn-tRNA that requires misacylated Asp-tRNAAsn as intermediate, which is generated by a Asp-tRNA synthetase
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
-
enzyme of the two-step pathway for the synthesis of Asn-tRNA that requires misacylated Asp-tRNAAsn as intermediate, which is generated by a Asp-tRNA synthetase
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
-
enzyme of the two-step pathway for the synthesis of Asn-tRNA that requires misacylated Asp-tRNAAsn as intermediate, which is generated by a Asp-tRNA synthetase
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
-
in vivo only Asn-tRNAAsn formation, because the substrate availability of Asp-tRNAAsn allows only one final product
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539
-
tRNA-dependent transamidation pathway of Asn-tRNA formation, only biosynthetic route to asparagine is via Asn-tRNA
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539
-
enzyme of the two-step pathway for the synthesis of Asn-tRNA that requires misacylated Asp-tRNAAsn as intermediate, which is generated by a Asp-tRNA synthetase
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
-
it is likely that the dual specificity amidotransferase serves in Asn-tRNA and Gln-tRNA formation in vivo
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
-
the mischarging Asp-tRNA synthetase correlates with the absence in the genome of Asn-tRNA synthetase and the presence of Asp-tRNAAsn amidotransferase, employed by the transamidation pathway
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
-
enzyme of the two-step pathway for the synthesis of Asn-tRNA that requires misacylated Asp-tRNAAsn as intermediate, which is generated by a Asp-tRNA synthetase
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
-
in vivo only Asn-tRNAAsn formation occurs, since Thermus possesses a mischarging Asp-tRNA synthetase, but lacks a mischarging Glu-tRNA synthetase, and cellular activity of AdTs only depends upon presence or lack of the mischarging amino acyl-tRNA synthetases, explaining why those enzymes have not restricted their specificity
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
-
AdT is related to the biosynthesis of asparagine rather than to provide charged tRNA for protein biosynthesis
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
-
tRNA-dependent transamidation pathway of Asn-tRNA formation, only biosynthetic route to asparagine is via Asn-tRNA
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
-
enzyme of the two-step pathway for the synthesis of Asn-tRNA that requires misacylated Asp-tRNAAsn as intermediate, which is generated by a Asp-tRNA synthetase
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
-
enzyme of the two-step pathway for the synthesis of Asn-tRNA that requires misacylated Asp-tRNAAsn as intermediate, which is generated by a Asp-tRNA synthetase
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
in vivo only Asn-tRNAAsn formation occurs, since Thermus possesses a mischarging Asp-tRNA synthetase, but lacks a mischarging Glu-tRNA synthetase, and cellular activity of AdTs only depends upon presence or lack of the mischarging amino acyl-tRNA synthetases, explaining why those enzymes have not restricted their specificity
-
?
Asp-tRNAAsn + ?
Asn-tRNAAsn + ?
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
enzyme of the two-step pathway for the synthesis of Asn-tRNA that requires misacylated Asp-tRNAAsn as intermediate, which is generated by a Asp-tRNA synthetase
-
?
ADP + phosphate + L-asparaginyl-tRNAAsn + L-glutamate
-
-
-
-
?
ATP + L-aspartyl-tRNAAsn + L-glutamine
ADP + phosphate + L-asparaginyl-tRNAAsn + L-glutamate
-
-
-
-
?
ATP + L-aspartyl-tRNAAsn + L-glutamine
ADP + phosphate + L-asparaginyl-tRNAAsn + L-glutamate
-
-
-
-
?
Gln-tRNAGln + ?
-
it is likely that the dual specificity amidotransferase serves in Asn-tRNA and Gln-tRNA formation in vivo
-
?
Glu-tRNAGln + ?
Gln-tRNAGln + ?
-
it is likely that the dual specificity amidotransferase serves in Asn-tRNA and Gln-tRNA formation in vivo
-
?
Glu-tRNAGln + ?
Gln-tRNAGln + ?
-
tRNA-dependent transamidation pathway of Gln-tRNA formation, which is required for protein synthesis or under certain metabolic situations for glutamine synthesis
-
?
Glu-tRNAGln + ?
Gln-tRNAGln + ?
-
it is likely that the dual specificity amidotransferase serves in Asn-tRNA and Gln-tRNA formation in vivo
-
?
?
-
-
the parasite Brugia malayi enzyme, in analogy to the human enzyme, induces human leukocyte chemotaxis and activates G-protein-coupled receptors CXCR1 and CXCR2, but not CXCR3, filarial asparaginyl-tRNA synthetase, AsnRS, is known to be an immunodominant antigen that induces strong human immunoglobulin G3 responses and contributes to the development of chronic inflammatory disease such as lymphatic filariasis, overview
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-
?
additional information
?
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human cytoplasmic aminoacyl-tRNA synthetases, which are autoantigens in idiopathic inflammatory myopathies, activate chemokine receptors on T lymphocytes, monocytes, and immature dendritic cells by recruiting immune cells that could induce innate and adaptive immune responses
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-
?