6.3.5.6: asparaginyl-tRNA synthase (glutamine-hydrolysing)

This is an abbreviated version!
For detailed information about asparaginyl-tRNA synthase (glutamine-hydrolysing), go to the full flat file.

Word Map on EC 6.3.5.6

6.3.5.6

gln-trnagln

transamidation

asn-trnaasn

aminoacyl-trnas

asparagine

mischarged

glutaminyl-trna

aminoacylation

archaea

heterotrimeric

synthetases

nondiscriminating

misacylated

helicobacter

gatde

transamidosome

nd-asprs

glutamyl-trnagln

pylori

glutaminase

thermautotrophicus

transamidase

asparaginylation

gln-trna

trnaglu

deinococcus

radiodurans

glutaminylated

methanothermobacter

mistranslation

trnaasp

anticodon-binding

d-loop

pharmacology

biotechnology

Reaction

Synonyms

AdT, AsnRS, Asp-AdT, Asp-tRNAAsn amidotransferase, Asp/Glu-Adt, asparaginyl-transfer RNA synthetase, Asparaginyl-tRNA synthetase, aspartyl-tRNAAsn amidotransferase, GatCAB, glutamine-dependent Asp-tRNAAsn/Glu-tRNAGln amidotransferase, NRS, tRNA-dependent amidotransferase

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor

6.3.5.6 asparaginyl-tRNA synthase (glutamine-hydrolysing)

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Results	in table
1403	AA Sequence
2	Application
1	CAS Registry Number
22	Cloned(Commentary)
5	Cofactor
1	Crystallization (Commentary)
8	Disease/ Diagnostics
3	IC50 Value
6	Inhibitors
9	KM Value [mM]
1	Localization
5	Metals/Ions
3	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
167	Organism
1	Pathway
2	pH Optimum
8	Protein Variants
6	Purification (Commentary)
4	Reaction
1	Reaction Type
50	Reference
3	Source Tissue
1	Specific Activity [micromol/min/mg]
129	Substrates and Products (Substrate)
30	Subunits
30	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
1	Temperature Stability [°C]
10	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 6.3.5.6 - asparaginyl-tRNA synthase (glutamine-hydrolysing)

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(3Z)-3-[(2E,4E)-1-hydroxy-6-[(2S,4R)-2-(hydroxymethyl)-1,7-dimethyl-5-oxo-3,9,10-trioxatricyclo[4.3.1.02,4]dec-8-yl]-4-methylhepta-2,4-dien-1-ylidene]pyrrolidine-2,4-dione

Brugia malayi

716420

WS9326A

Brugia malayi

little inhibitory activity at 0.1 mM

728424

WS9326C

Brugia malayi

little inhibitory activity at 0.1 mM

728424

WS9326D

Brugia malayi

specific inhibitor, moderate inhibition

728424

WS9326E

Brugia malayi

moderate inhibition

728424

additional information

Chlamydia trachomatis

not inhibited by N-ethylmaleimide, 5,5-dithiobis(2-nitrobenzoic acid) and p-hydroxymercuribenzoate

440092