6.3.5.6: asparaginyl-tRNA synthase (glutamine-hydrolysing)

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For detailed information about asparaginyl-tRNA synthase (glutamine-hydrolysing), go to the full flat file.

Word Map on EC 6.3.5.6

6.3.5.6

gln-trnagln

transamidation

asn-trnaasn

aminoacyl-trnas

asparagine

mischarged

glutaminyl-trna

aminoacylation

archaea

heterotrimeric

synthetases

nondiscriminating

misacylated

helicobacter

gatde

transamidosome

nd-asprs

glutamyl-trnagln

pylori

glutaminase

thermautotrophicus

transamidase

asparaginylation

gln-trna

trnaglu

deinococcus

radiodurans

glutaminylated

methanothermobacter

mistranslation

trnaasp

anticodon-binding

d-loop

pharmacology

biotechnology

Reaction

Synonyms

AdT, AsnRS, Asp-AdT, Asp-tRNAAsn amidotransferase, Asp/Glu-Adt, asparaginyl-transfer RNA synthetase, Asparaginyl-tRNA synthetase, aspartyl-tRNAAsn amidotransferase, GatCAB, glutamine-dependent Asp-tRNAAsn/Glu-tRNAGln amidotransferase, NRS, tRNA-dependent amidotransferase

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor

6.3.5.6 asparaginyl-tRNA synthase (glutamine-hydrolysing)

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Results	in table
1403	AA Sequence
2	Application
1	CAS Registry Number
22	Cloned(Commentary)
5	Cofactor
1	Crystallization (Commentary)
8	Disease/ Diagnostics
3	IC50 Value
6	Inhibitors
9	KM Value [mM]
1	Localization
5	Metals/Ions
3	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
167	Organism
1	Pathway
2	pH Optimum
8	Protein Variants
6	Purification (Commentary)
4	Reaction
1	Reaction Type
50	Reference
3	Source Tissue
1	Specific Activity [micromol/min/mg]
129	Substrates and Products (Substrate)
30	Subunits
30	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
1	Temperature Stability [°C]
10	Turnover Number [1/s]

Disease

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Disease on EC 6.3.5.6 - asparaginyl-tRNA synthase (glutamine-hydrolysing)

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Cardiomyopathies

Pathogenic variants in glutamyl-tRNAGln amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder.

30283131

Otitis Media

Natural insertion of the bro-1 ?-lactamase gene into the gatCAB operon affects Moraxella catarrhalis aspartyl-tRNAAsn amidotransferase activity.

22745266

Tuberculosis

Clinically Relevant Mutations of Mycobacterial GatCAB Inform Regulation of Translational Fidelity.

34225495