6.3.4.3: formate-tetrahydrofolate ligase

This is an abbreviated version!
For detailed information about formate-tetrahydrofolate ligase, go to the full flat file.

Word Map on EC 6.3.4.3

6.3.4.3

trifunctional

one-carbon

5,10-methylenetetrahydrofolate

acetogens

mthfr

5,10-methenyltetrahydrofolate

homoacetogens

folate-dependent

acetogenesis

cylindrosporum

thermoaceticum

folate-mediated

1.5.1.5

dehydrogenase-cyclohydrolase

5,10-methenyl-thf

5,10-methylene-thf

biogas

acetobacterium

acidi-urici

syntrophic

pharmacology

Reaction

Synonyms

10-CHO-THF synthase, 10-formyl-THF synthetase, 10-Formyltetrahydrofolate synthetase, 10-formylTHF synthetase, ADE3, C(1)-tetrahydrofolate synthase, C1 synthase, C1-tetrahydrofolate synthase, C1-tetrahydrofolate synthetase, C1-THF synthase, C1-THFS, CpeFhs, DCS, dehydrogenasse-cyclohydrolase-synthetase, FHS, formate-tetrahydrofolate ligase, formate:tetrahydrofolate ligase (ADP-forming), formyl tetrahydrofolate synthetase, Formyl-THF synthetase, Formyltetrahydrofolate synthetase, ftfL, FTHFS, FTL, methylenetetrahydrofolate dehydrogenase 1-like, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase enzyme, MIS1, MTHFD, MTHFD1, MTHFD1L, MTHFDIL, N10-formyltetrahydrofolate synthetase, NAD-dependent methylenetetrahydrofolate dehydrogenase, Synthetase, formyl tetrahydrofolate, Tetrahydrofolate formylase, Tetrahydrofolic formylase, THF synthase, THFS

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.4 Other carbon-nitrogen ligases

6.3.4.3 formate-tetrahydrofolate ligase

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Results	in table
1	Activating Compound
25312	AA Sequence
3	Application
1	CAS Registry Number
56	Cloned(Commentary)
21	Cofactor
6	Crystallization (Commentary)
101	Disease/ Diagnostics
2	Expression
26	General Information
9	General Stability
5	IC50 Value
44	Inhibitors
4	Ki Value [mM]
95	KM Value [mM]
18	Localization
61	Metals/Ions
23	Molecular Weight [Da]
57	Natural Substrates/ Products (Substrates)
180	Organism
14	Pathway
46	PDB ID
4	pH Optimum
1	pH Stability
22	Protein Variants
22	Purification (Commentary)
8	Reaction
5	Reaction Type
148	Reference
2	Renatured (Commentary)
96	Source Tissue
23	Specific Activity [micromol/min/mg]
1	Storage Stability
185	Substrates and Products (Substrate)
18	Subunits
191	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
10	Temperature Stability [°C]
13	Turnover Number [1/s]

KM Value

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KM Value on EC 6.3.4.3 - formate-tetrahydrofolate ligase

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0.33

(6R,S)-5,6,7,8-tetrahydrofolate

Clostridium perfringens

Q0TMI3

pH 8.2, temperature not specified in the publication

743250

0.33

(6R,S)-tetrahydrofolate

2 entries

0.5

(6R,S)-tetrahydrofolate monoglutamate

Homo sapiens

above, recombinant enzyme, 30°C

660817

0.0036

(6R,S)-tetrahydrofolate pteroylpentaglutamate

Homo sapiens

recombinant enzyme, 30°C

660817

0.016

(6R,S)-tetrahydrofolate pteroyltriglutamate

Homo sapiens

recombinant enzyme, 30°C

660817

0.0055 - 0.029

5,6,7,8-tetrahydropteroyldiglutamate

2 entries

0.003

5,6,7,8-tetrahydropteroylpentaglutamate

Pisum sativum

1518, 1528

0.0001

5,6,7,8-tetrahydropteroyltetraglutamate

Oryctolagus cuniculus

tetrahydropteroyl-Glu5

1529

0.0003 - 0.025

5,6,7,8-tetrahydropteroyltriglutamate

5 entries

0.032 - 0.13

ADP

3 entries

0.012 - 0.59

ATP

25 entries

11.9

Carbamoyl phosphate

Clostridium cylindrosporum

1508

0.035 - 38

formate

22 entries

N10-formyltetrahydrofolate

Clostridium cylindrosporum

1506

phosphate

Clostridium cylindrosporum

1506

0.015 - 2.3

tetrahydrofolate

14 entries

additional information

6 entries