6.3.4.3: formate-tetrahydrofolate ligase

This is an abbreviated version!
For detailed information about formate-tetrahydrofolate ligase, go to the full flat file.

Word Map on EC 6.3.4.3

6.3.4.3

trifunctional

one-carbon

5,10-methylenetetrahydrofolate

acetogens

mthfr

5,10-methenyltetrahydrofolate

homoacetogens

folate-dependent

acetogenesis

cylindrosporum

thermoaceticum

folate-mediated

1.5.1.5

dehydrogenase-cyclohydrolase

5,10-methenyl-thf

5,10-methylene-thf

biogas

acetobacterium

acidi-urici

syntrophic

pharmacology

Reaction

Synonyms

10-CHO-THF synthase, 10-formyl-THF synthetase, 10-Formyltetrahydrofolate synthetase, 10-formylTHF synthetase, ADE3, C(1)-tetrahydrofolate synthase, C1 synthase, C1-tetrahydrofolate synthase, C1-tetrahydrofolate synthetase, C1-THF synthase, C1-THFS, CpeFhs, DCS, dehydrogenasse-cyclohydrolase-synthetase, FHS, formate-tetrahydrofolate ligase, formate:tetrahydrofolate ligase (ADP-forming), formyl tetrahydrofolate synthetase, Formyl-THF synthetase, Formyltetrahydrofolate synthetase, ftfL, FTHFS, FTL, methylenetetrahydrofolate dehydrogenase 1-like, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase enzyme, MIS1, MTHFD, MTHFD1, MTHFD1L, MTHFDIL, N10-formyltetrahydrofolate synthetase, NAD-dependent methylenetetrahydrofolate dehydrogenase, Synthetase, formyl tetrahydrofolate, Tetrahydrofolate formylase, Tetrahydrofolic formylase, THF synthase, THFS

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.4 Other carbon-nitrogen ligases

6.3.4.3 formate-tetrahydrofolate ligase

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Results	in table
1	Activating Compound
25312	AA Sequence
3	Application
1	CAS Registry Number
56	Cloned(Commentary)
21	Cofactor
6	Crystallization (Commentary)
101	Disease/ Diagnostics
2	Expression
26	General Information
9	General Stability
5	IC50 Value
44	Inhibitors
4	Ki Value [mM]
95	KM Value [mM]
18	Localization
61	Metals/Ions
23	Molecular Weight [Da]
57	Natural Substrates/ Products (Substrates)
180	Organism
14	Pathway
46	PDB ID
4	pH Optimum
1	pH Stability
22	Protein Variants
22	Purification (Commentary)
8	Reaction
5	Reaction Type
148	Reference
2	Renatured (Commentary)
96	Source Tissue
23	Specific Activity [micromol/min/mg]
1	Storage Stability
185	Substrates and Products (Substrate)
18	Subunits
191	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
10	Temperature Stability [°C]
13	Turnover Number [1/s]

Crystallization

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Crystallization on EC 6.3.4.3 - formate-tetrahydrofolate ligase

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3 entries

crystals of FTHFS complexed with NH4+, K+ or Cs+ are grown by vapor diffusion from 46% saturated ammonium sulfate, 1 mM dithiothreitol and 1% polyehtylene glycol 1000 in 50 mM potassium maleate buffer, pH 7.6, crystals diffract to 3.0-3.2 A resolution

Moorella thermoacetica

P21164

649939

native protein, folate complex, ADP-formylphosphate complex, and ZD9331-formylphosphate complex, hanging drop vapor diffusion method. High salt conditions contain 38-46% (w/v) saturated ammonium sulfate, 1 mM , and dithiohtreitol, 1-3.5% (w/v) PEG 1000 or PEG 1450, in 50-75 mM KMB (pH 7.0-8.0). Low salt conditions contain 18-22% (w/v) PEG 6-8K, 0.2 M ammonium sulfate, 1 mM dithiothreitol, in 75 mM KMB pH 7.0-8.5

Moorella thermoacetica

P21164

728759

Se-Met FTHFS is crystallized by hanging-drop vapor-diffusion, crystals diffract to 2.5 A

Moorella thermoacetica

P21164

649968