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6.3.4.3: formate-tetrahydrofolate ligase

This is an abbreviated version!
For detailed information about formate-tetrahydrofolate ligase, go to the full flat file.

Word Map on EC 6.3.4.3

Reaction

ATP
+
formate
+
tetrahydrofolate
=
ADP
+
phosphate
+
10-formyltetrahydrofolate

Synonyms

10-CHO-THF synthase, 10-formyl-THF synthetase, 10-Formyltetrahydrofolate synthetase, 10-formylTHF synthetase, ADE3, C(1)-tetrahydrofolate synthase, C1 synthase, C1-tetrahydrofolate synthase, C1-tetrahydrofolate synthetase, C1-THF synthase, C1-THFS, CpeFhs, DCS, dehydrogenasse-cyclohydrolase-synthetase, FHS, formate-tetrahydrofolate ligase, formate:tetrahydrofolate ligase (ADP-forming), formyl tetrahydrofolate synthetase, Formyl-THF synthetase, Formyltetrahydrofolate synthetase, ftfL, FTHFS, FTL, methylenetetrahydrofolate dehydrogenase 1-like, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase enzyme, MIS1, MTHFD, MTHFD1, MTHFD1L, MTHFDIL, N10-formyltetrahydrofolate synthetase, NAD-dependent methylenetetrahydrofolate dehydrogenase, Synthetase, formyl tetrahydrofolate, Tetrahydrofolate formylase, Tetrahydrofolic formylase, THF synthase, THFS

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.4 Other carbon-nitrogen ligases
                6.3.4.3 formate-tetrahydrofolate ligase

Substrates Products

Substrates Products on EC 6.3.4.3 - formate-tetrahydrofolate ligase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R,S)-tetrahydrofolate + ATP + formate
?
show the reaction diagram
-
-
-
r
ADP + carbamoylphosphate + tetrahydrofolate
ATP + ?
show the reaction diagram
-
-
-
?
ADP + phosphate + 10-formyltetrahydrofolate
?
show the reaction diagram
ATP + (6R,S)-tetrahydrofolate pteroylpentaglutamate
ADP + phosphate + 10-formyltetrahydrofolate pteroylpentaglutamate
show the reaction diagram
-
-
-
-
?
ATP + (6R,S)-tetrahydrofolate pteroyltriglutamate
ADP + phosphate + 10-formyltetrahydrofolate pteroyltriglutamate
show the reaction diagram
-
-
-
-
?
ATP + formate
ADP + HCOOPO32-
show the reaction diagram
ATP + formate + (6R,S)-5,6,7,8-tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
show the reaction diagram
ATP + formate + (6R,S)-tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
show the reaction diagram
ATP + formate + (6R,S)-tetrahydrofolate monoglutamate
ADP + phosphate + 10-formyltetrahydrofolate monoglutamate
show the reaction diagram
-
-
-
-
?
ATP + formate + 5,6,7,8-tetrahydropteroyldiglutamate
ADP + phosphate + 10-formyltetrahydrofolyldiglutamate
show the reaction diagram
ATP + formate + 5,6,7,8-tetrahydropteroylpentaglutamate
ADP + phosphate + 10-formyltetrahydrofolylpentaglutamate
show the reaction diagram
-
-
-
-
?
ATP + formate + 5,6,7,8-tetrahydropteroyltetraglutamate
ADP + phosphate + 10-formyltetrahydrofolyltetraglutamate
show the reaction diagram
-
-
-
-
?
ATP + formate + 5,6,7,8-tetrahydropteroyltriglutamate
ADP + phosphate + 10-formyltetrahydrofolyltriglutamate
show the reaction diagram
ATP + formate + tetrahydrofolate
?
show the reaction diagram
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
show the reaction diagram
ATP + formate + tetrahydropteroyl-(Glu)n
ADP + phosphate + 10-formyltetrahydropteroyl-(Glu)n
show the reaction diagram
Carbamoyl phosphate + ADP
? + ATP
show the reaction diagram
dATP + formate + tetrahydrofolate
dADP + phosphate + 10-formyltetrahydrofolate
show the reaction diagram
-
37% of the activity relative to ATP
-
-
?
formate + ATP + tetrahydrofolate
10-formyltetrahydrofolate + ADP + phosphate
show the reaction diagram
synthetase activity of MTHFD1
-
-
?
tetrahydrofolate + formate + ATP
10-formyltetrahydrofolate + ADP + phosphate
show the reaction diagram
additional information
?
-