6.3.4.3: formate-tetrahydrofolate ligase

This is an abbreviated version!
For detailed information about formate-tetrahydrofolate ligase, go to the full flat file.

Reaction

Synonyms

10-CHO-THF synthase, 10-formyl-THF synthetase, 10-Formyltetrahydrofolate synthetase, 10-formylTHF synthetase, ADE3, C(1)-tetrahydrofolate synthase, C1 synthase, C1-tetrahydrofolate synthase, C1-tetrahydrofolate synthetase, C1-THF synthase, C1-THFS, CpeFhs, DCS, dehydrogenasse-cyclohydrolase-synthetase, FHS, formate-tetrahydrofolate ligase, formate:tetrahydrofolate ligase (ADP-forming), formyl tetrahydrofolate synthetase, Formyl-THF synthetase, Formyltetrahydrofolate synthetase, ftfL, FTHFS, FTL, methylenetetrahydrofolate dehydrogenase 1-like, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase enzyme, MIS1, MTHFD, MTHFD1, MTHFD1L, MTHFDIL, N10-formyltetrahydrofolate synthetase, NAD-dependent methylenetetrahydrofolate dehydrogenase, Synthetase, formyl tetrahydrofolate, Tetrahydrofolate formylase, Tetrahydrofolic formylase, THF synthase, THFS

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.4 Other carbon-nitrogen ligases

                6.3.4.3 formate-tetrahydrofolate ligase

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1	Activating Compound
25312	AA Sequence
3	Application
1	CAS Registry Number
56	Cloned(Commentary)
21	Cofactor
6	Crystallization (Commentary)
101	Disease/ Diagnostics
2	Expression
26	General Information
9	General Stability
5	IC50 Value
44	Inhibitors
4	Ki Value [mM]
95	KM Value [mM]
18	Localization
61	Metals/Ions
23	Molecular Weight [Da]
57	Natural Substrates/ Products (Substrates)
180	Organism
14	Pathway
46	PDB ID
4	pH Optimum
1	pH Stability
22	Protein Variants
22	Purification (Commentary)
8	Reaction
5	Reaction Type
148	Reference
2	Renatured (Commentary)
96	Source Tissue
23	Specific Activity [micromol/min/mg]
1	Storage Stability
185	Substrates and Products (Substrate)
18	Subunits
191	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
10	Temperature Stability [°C]
13	Turnover Number [1/s]

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Application on EC 6.3.4.3 - formate-tetrahydrofolate ligase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

drug development

Homo sapiens

Q6UB35

MTHFD1L overexpression is closely associated with aggressive clinicopathological features of hepatocellular carcinoma (HCC) including the presence of tumor microsatellite formation, venous invasion, and more advanced tumor stages. The enzyme MTHFD1L is a potential target in cancer therapy. Inhibition of the folate cycle sensitizes HCC cells to sorafenib treatment in vitro and in vivo

765141

medicine

Homo sapiens

Q6UB35

MTHFD1L may be involved in OSCC progression via the c-MYC gene and p53 signaling and may serve as a target and orientation for tumor therapy

765861

pharmacology

Homo sapiens

Q6UB35

the enzyme might be a target for colorectal cancer therapy

660866