6.3.4.3: formate-tetrahydrofolate ligase

This is an abbreviated version!
For detailed information about formate-tetrahydrofolate ligase, go to the full flat file.

Reaction

Synonyms

10-CHO-THF synthase, 10-formyl-THF synthetase, 10-Formyltetrahydrofolate synthetase, 10-formylTHF synthetase, ADE3, C(1)-tetrahydrofolate synthase, C1 synthase, C1-tetrahydrofolate synthase, C1-tetrahydrofolate synthetase, C1-THF synthase, C1-THFS, CpeFhs, DCS, dehydrogenasse-cyclohydrolase-synthetase, FHS, formate-tetrahydrofolate ligase, formate:tetrahydrofolate ligase (ADP-forming), formyl tetrahydrofolate synthetase, Formyl-THF synthetase, Formyltetrahydrofolate synthetase, ftfL, FTHFS, FTL, methylenetetrahydrofolate dehydrogenase 1-like, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase enzyme, MIS1, MTHFD, MTHFD1, MTHFD1L, MTHFDIL, N10-formyltetrahydrofolate synthetase, NAD-dependent methylenetetrahydrofolate dehydrogenase, Synthetase, formyl tetrahydrofolate, Tetrahydrofolate formylase, Tetrahydrofolic formylase, THF synthase, THFS

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.4 Other carbon-nitrogen ligases

                6.3.4.3 formate-tetrahydrofolate ligase

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Results	in table
1	Activating Compound
25312	AA Sequence
3	Application
1	CAS Registry Number
56	Cloned(Commentary)
21	Cofactor
6	Crystallization (Commentary)
101	Disease/ Diagnostics
2	Expression
26	General Information
9	General Stability
5	IC50 Value
44	Inhibitors
4	Ki Value [mM]
95	KM Value [mM]
18	Localization
61	Metals/Ions
23	Molecular Weight [Da]
57	Natural Substrates/ Products (Substrates)
180	Organism
14	Pathway
46	PDB ID
4	pH Optimum
1	pH Stability
22	Protein Variants
22	Purification (Commentary)
8	Reaction
5	Reaction Type
148	Reference
2	Renatured (Commentary)
96	Source Tissue
23	Specific Activity [micromol/min/mg]
1	Storage Stability
185	Substrates and Products (Substrate)
18	Subunits
191	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
10	Temperature Stability [°C]
13	Turnover Number [1/s]

Organism

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of the Enzyme Summary Page.

Organism on EC 6.3.4.3 - formate-tetrahydrofolate ligase

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Acetitomaculum ruminis

-

701825

-

-

brenda

Acetobacterium carbinolicum

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

Q15K82

UniProt

brenda

Acetobacterium psammolithicum

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

Q8GMP9

UniProt

brenda

Acetobacterium woodii

2 entries

Bacillus subtilis

W168

1530

-

-

brenda

Bacillus subtilis W168

W168

1530

-

-

brenda

Bacteroides fragilis

-

1530

-

-

brenda

Blautia producta

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

Q9AHR6

UniProt

brenda

Blautia sp. Ser5

-

701825

-

-

brenda

Blautia sp. Ser8

-

701825

-

-

brenda

Bos taurus

-

1504

-

-

brenda

Caldanaerobacter subterraneus subsp. tengcongensis

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

Q8R7L3

UniProt

brenda

Cavia porcellus

-

1504

-

-

brenda

Clostridium aceticum

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

Q9AHR8

UniProt

brenda

Clostridium acidi-urici

3 entries

Clostridium acidi-urici 9a

9a

1530

-

-

brenda

Clostridium cylindrosporum

2 entries

Clostridium formicaceticum

fragment; isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

Q9AHS1

UniProt

brenda

Clostridium magnum

-

701825

-

-

brenda

Clostridium pasteurianum

-

1530

-

-

brenda

Clostridium perfringens

5 entries

Clostridium perfringens DSM 756

-

742789, 743250

Q0TMI3

UniProt

brenda

Clostridium sardiniense

-

1530

-

-

brenda

Clostridium sp.

-

701825

-

-

brenda

Cryptotermes secundus

-

673366

-

-

brenda

Desulfovibrio piger

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

-

-

brenda

Enterococcus faecalis

19433

1530

-

-

brenda

Enterococcus faecalis 19433

19433

1530

-

-

brenda

Escherichia coli

-

1506

-

-

brenda

Eubacterium limosum

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

Q8GJ02, Q9AHR7

UniProt

brenda

Eubacterium sp.

-

1530, 701825

-

-

brenda

Eubacterium sp. VPI 12708

-

1530

-

-

brenda

Gallus gallus

-

1506

-

-

brenda

Gottschalkia acidurici

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

P13419

UniProt

brenda

Homo sapiens

10 entries

Leishmania major

-

700281

-

-

brenda

Mesorhizobium loti

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

-

-

brenda

Mesorhizobium sp.

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

-

-

brenda

Mesorhizobium sp. BNC1

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

-

-

brenda

Methylorubrum extorquens

-

651731

Q83WS0

SwissProt

brenda

Methylorubrum extorquens ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1

-

651731

Q83WS0

SwissProt

brenda

Micrococcus aerogenes

-

1506

-

-

brenda

Micrococcus luteus

4698

1530

-

-

brenda

Micrococcus luteus 4698

4698

1530

-

-

brenda

Moorella thermoacetica

4 entries

Moraxella catarrhalis

25238, weak activity

1530

-

-

brenda

Mus musculus

4 entries

Mycolicibacterium smegmatis

-

1530

-

-

brenda

Neurospora crassa

-

1506

-

-

brenda

Oryctolagus cuniculus

2 entries

Ovis aries

trifunctional enzyme with 10-formyltetrahydrofolate synthetase, EC 6.3.4.3, 5,10-methenyltetrahydrofolate cyclohydrolase, EC 3.5.4.9, and 5,10-methylenetetrahydrofolate dehydrogenase activity, EC 1.5.1.5

1505, 1506

-

-

brenda

Oxobacter pfennigii

-

701825

-

-

brenda

Peptoniphilus asaccharolyticus

-

1509

-

-

brenda

Peptostreptococcus anaerobius

27337

1530

-

-

brenda

Peptostreptococcus anaerobius 27337

27337

1530

-

-

brenda

Pigeon

-

1506

-

-

brenda

Pisum sativum

2 entries

Priestia megaterium

-

1506

-

-

brenda

Proteus mirabilis

25433

1530

-

-

brenda

Proteus mirabilis 25433

25433

1530

-

-

brenda

Proteus vulgaris

-

1506

-

-

brenda

Rattus norvegicus

-

1504, 650943, 651414, 690632

-

-

brenda

Reticulitermes santonensis

-

673366

-

-

brenda

Rhizobium leguminosarum

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

-

-

brenda

Rhodobacterales

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

-

-

brenda

Saccharomyces cerevisiae

3 entries

Sinorhizobium medicae

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

-

-

brenda

Sinorhizobium meliloti

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

-

-

brenda

Sphingomonas paucimobilis

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

-

-

brenda

Spinacia oleracea

spinach

1506, 1519, 1520

-

-

brenda

Sporomusa ovata

2 entries

Sporomusa termitida

fragment; isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

Q9AHR4

UniProt

brenda

Staphylococcus epidermidis

14990

1530

-

-

brenda

Staphylococcus epidermidis 14990

14990

1530

-

-

brenda

Sus scrofa

trifunctional enzyme with 10-formyltetrahydrofolate synthetase, EC 6.3.4.3, 5,10-methenyltetrahydrofolate cyclohydrolase, EC 3.5.4.9, and 5,10-methylenetetrahydrofolate dehydrogenase activity, EC 1.5.1.5

1505

-

-

brenda

Thermacetogenium phaeum

-

728254

D4QDA0

UniProt

brenda

Thermacetogenium phaeum DSM 12270

-

728254

D4QDA0

UniProt

brenda

Thermoanaerobacter kivui

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

Q9AHR9

UniProt

brenda

Thermoplasma acidophilum

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

Q9HI67

UniProt

brenda

Treponema denticola

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

-

-

brenda

Treponema primitia

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

Q8GIN9

UniProt

brenda

uncultured microorganism

-

728254

A7BK03, A7BK04, A7BK05, A7BK06, A7BK07, A7BK08, A7BK09, A7BK10, A7BK11, A7BK12, A7BK13, A7BK14, A7BK15, A7BK16, A7BK17

UniProt

brenda

Veillonella parvula

-

1506

-

-

brenda

Zootermopsis nevadensis

-

673366

-

-

brenda

Acetobacterium woodii

-

701825

Q9AHS2

UniProt

brenda

Acetobacterium woodii

fragment; isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

Q9AHS2

UniProt

brenda

Clostridium acidi-urici

-

1506, 1510, 1514, 1516, 1517

-

-

brenda

Clostridium acidi-urici

9a

1530

-

-

brenda

Clostridium acidi-urici

monofunctional enzyme

1531

-

-

brenda

Clostridium cylindrosporum

-

1506, 1508, 1510, 1511, 1512, 1514, 1515, 1516, 1521, 1523, 1526

-

-

brenda

Clostridium cylindrosporum

wild-type and site-directed mutant enzymes H125S, H131S, and H268S

1524

-

-

brenda

Clostridium perfringens

-

742789

Q0TMI3

UniProt

brenda

Clostridium perfringens

-

743250

-

-

brenda

Clostridium perfringens

-

743250

Q0TMI3

UniProt

brenda

Clostridium perfringens

-

744335

-

-

brenda

Clostridium perfringens

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

-

-

brenda

Homo sapiens

-

652471

Q6UB35

SwissProt

brenda

Homo sapiens

-

660817

-

-

brenda

Homo sapiens

-

673440

P11586

UniProt

brenda

Homo sapiens

-

690632, 693974

-

-

brenda

Homo sapiens

-

698187

P11586

UniProt

brenda

Homo sapiens

-

701402

-

-

brenda

Homo sapiens

-

765141, 765861

Q6UB35

SwissProt

brenda

Homo sapiens

mutation in MTHFD can act as a risk factor in human neural tube defects, however, it is unlikely that this gene plays a major role in the etiology of neural tube defects

650869

-

-

brenda

Homo sapiens

trifunctional enzyme

660866

Q6UB35

SwissProt

brenda

Homo sapiens

trifunctional enzyme with 10-formyltetrahydrofolate synthetase, EC 6.3.4.3, 5,10-methenyltetrahydrofolate cyclohydrolase, EC 3.5.4.9, and 5,10-methylenetetrahydrofolate dehydrogenase activity, EC 1.5.1.5

1504, 1506, 1522

-

-

brenda

Moorella thermoacetica

-

1502, 1506, 1507, 1513, 1525, 1527, 649471

-

-

brenda

Moorella thermoacetica

-

649939, 728759

P21164

UniProt

brenda

Moorella thermoacetica

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

P21164

UniProt

brenda

Moorella thermoacetica

previously referred to as Clostridium thermoaceticum

649968

P21164

UniProt

brenda

Mus musculus

-

1504

-

-

brenda

Mus musculus

-

712483

Q3V3R1

UniProt

brenda

Mus musculus

-

727607

-

-

brenda

Mus musculus

DCS, complete gene and exon 27; gene mthfd1 encodes the cytosolic isozyme which is a trifunctional methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase enzyme DCS, a mitochondrial monofunctional 10-formyltetrahydrofolate synthetase isozyme is encoded by a different gene

662447

Q922D8

SwissProt

brenda

Oryctolagus cuniculus

-

1503, 1506

-

-

brenda

Oryctolagus cuniculus

trifunctional enzyme with 10-formyltetrahydrofolate synthetase, EC 6.3.4.3, 5,10-methenyltetrahydrofolate cyclohydrolase, EC 3.5.4.9, and 5,10-methylenetetrahydrofolate dehydrogenase activity, EC 1.5.1.5

1529, 1532

-

-

brenda

Pisum sativum

-

1506, 1528

-

-

brenda

Pisum sativum

monofunctional enzyme

1518

-

-

brenda

Saccharomyces cerevisiae

-

1526

-

-

brenda

Saccharomyces cerevisiae

-

701402

P07245, P09440

UniProt

brenda

Saccharomyces cerevisiae

trifunctional enzyme with 10-formyltetrahydrofolate synthetase, EC 6.3.4.3, 5,10-methenyltetrahydrofolate cyclohydrolase, EC 3.5.4.9, and 5,10-methylenetetrahydrofolate dehydrogenase activity, EC 1.5.1.5

1505, 1506

-

-

brenda

Sporomusa ovata

-

701825

-

-

brenda

Sporomusa ovata

isolated from environmental samples collected from different sites in Wux, China, gene fths

701658

Q9AHR5

UniProt

brenda