Reference on EC 6.3.4.3 - formate-tetrahydrofolate ligase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lovell, C.R.; Przybyla, A.; Ljungdahl, L.G.
Cloning and expression in Escherichia coli of the Clostridium thermoaceticum gene encoding thermostable formyltetrahydrofolate synthetase
Arch. Microbiol.
149
280-285
1988
Moorella thermoacetica
Strong, W.; Joshi, G.; Lura, R.; Muthukumaraswamy, N.; Schirch, V.
10-Formyltetrahydrofolate synthetase. Evidence for a conformational change in the enzyme upon binding of tetrahydropteroylpolyglutamates
J. Biol. Chem.
262
12519-12525
1987
Oryctolagus cuniculus
Schegg, K.M.; Welch jr., W.
The effect of nordihydroguaiaretic acid and related lignans on formyltetrahydrofolate synthetase and carboxylesterase
Biochim. Biophys. Acta
788
167-180
1984
Bos taurus, Cavia porcellus, Homo sapiens, Mus musculus, Rattus norvegicus
Paukert, J.L.; Rabinowitz, J.C.
Formyl-methenyl-methylenetetrahydrofolate synthetase (combined): a multifunctional protein in eukaryotic folate metabolism
Methods Enzymol.
66
616-626
1980
Saccharomyces cerevisiae, Ovis aries, Sus scrofa
Buttlaire, D.H.
Purification and properties of formyltetrahydrofolate synthetase
Methods Enzymol.
66
585-599
1980
Clostridium acidi-urici, Clostridium cylindrosporum, Escherichia coli, Gallus gallus, Homo sapiens, Micrococcus aerogenes, Moorella thermoacetica, Neurospora crassa, Oryctolagus cuniculus, Ovis aries, Pigeon, Pisum sativum, Priestia megaterium, Proteus vulgaris, Saccharomyces cerevisiae, Spinacia oleracea, Veillonella parvula
Elliott, J.I.; Ljungdahl, L.G.
Chemical modification of cysteine and tyrosine residues in formyltetrahydrofolate synthetase from Clostridium thermoaceticum
Arch. Biochem. Biophys.
215
245-252
1982
Moorella thermoacetica
Buttlaire, D.H.; Balfe, C.A.; Wendland, M.F.; Himes, R.H.
Carbamyl phosphate-dependent ATP synthesis catalyzed by formyltetrahydrofolate synthetase
Biochim. Biophys. Acta
567
453-463
1979
Clostridium cylindrosporum
McGuire, J.J.; Rabinowitz, J.C.
Studies on the mechanism of formyltetrahydrofolate synthetase. The Peptococcus aerogenes enzyme
J. Biol. Chem.
253
1079-1085
1978
Peptoniphilus asaccharolyticus
Garrison, C.K.; Harmony, J.A.K.; Himes, R.H.
Renaturation of formyltetrahydrofolate synthetase from urea and guanidinium chloride solution
Biochim. Biophys. Acta
446
301-309
1976
Clostridium acidi-urici, Clostridium cylindrosporum
Buttlaire, D.H.; Himes, R.H.; Reed, G.H.
Formyltetrahydrofolate synthetase-catalyzed formation of ATP from carbamyl phosphate and ADP
J. Biol. Chem.
251
4159-4161
1976
Clostridium cylindrosporum
Harmony, J.A.K.; Himes, R.H.; Schowen, R.L.
The monovalent cation-induced association of formyltetrahydrofolate synthetase subunits: a solvent isotope effect
Biochemistry
14
5379-5386
1975
Clostridium cylindrosporum
Shoaf, W.T.; Neece, S.H.; Ljungdahl, L.G.
Effects of temperature and ammonium ions on formyltetrahydrofolate synthetase from Clostridium thermoaceticum
Biochim. Biophys. Acta
334
448-458
1974
Moorella thermoacetica
-
Harmony, J.A.K.; Shaffer, P.J.; Himes, R.H.
Cation- and anion-dependent reassociation of formyltetrahydrofolate synthetase subunits
J. Biol. Chem.
249
394-401
1974
Clostridium acidi-urici, Clostridium cylindrosporum
Buttlaire, D.H.; Hersh, R.T.; Himes, R.H.
Hydrogen ion-induced reversible inactivation and dissociation of formyltetrahydrofolate synthetase
J. Biol. Chem.
247
2059-2068
1972
Clostridium cylindrosporum
Curthoys, N.P.; Rabinowitz, J.C.
Formyltetrahydrofolate synthetase. Binding of folate substrates and kinetics of the reverse reaction
J. Biol. Chem.
247
1965-1971
1972
Clostridium acidi-urici, Clostridium cylindrosporum
Mackenzie, R.E.; dAri Straus, L.; Rabinowitz, J.C.
Photooxidation of formyltetrahydrofolate synthetase in the presence of methylene blue
Arch. Biochem. Biophys.
150
421-427
1972
Clostridium acidi-urici
Cossins, E.A.; Kirk, C.D.; Imeson, H.C.; Zheng, L.l.
Enzymes for synthesis of 10-formyltetrahydrofolate in plants. Characterization of a monofunctional 10-formyltetrahydrofolate synthetase and copurification of 5,10-methylenetetrahydrofolate dehydrogenase and 5,10-methenyltetrahydrofolate cyclohydrolase activities
Adv. Exp. Med. Biol.
338
707-710
1993
Pisum sativum
Nour, J.M.; Rabinowitz, J.C.
Isolation, characterization, and structural organization of 10-formyltetrahydrofolate synthetase from spinach leaves
J. Biol. Chem.
266
18363-18369
1991
Spinacia oleracea
Nour, J.M.; Rabinowitz, J.C.
Isolation and sequencing of the cDNA coding for spinach 10-formyltetrahydrofolate synthetase
J. Biol. Chem.
267
16292-16296
1992
Spinacia oleracea
Song, S.; Jahansouz, H.; Himes, R.H.
Solvent oxygen is not incorporated into N10-formyltetrahydrofolate in the reaction catalyzed by N10-formyltetrahydrofolate synthetase
FEBS Lett.
332
150-152
1993
Clostridium cylindrosporum
Hum, D.W.; MacKenzie, R.E.
Expression of active domains of a human folate-dependent trifunctional enzyme in Escherichia coli
Protein Eng.
4
493-500
1991
Homo sapiens
Rankin, C.A.; Haslam, G.C.; Himes, R.H.
Sequence and expression of the gene for N10-formyltetrahydrofolate synthetase from Clostridium cylindrosporum
Protein Sci.
2
197-205
1993
Clostridium cylindrosporum
Kounga, K.; Song, S.; Haslam, G.C.; Himes, R.H.
Site-directed mutagenesis of putative catalytic and nucleotide binding sites in N10-formyltetrahydrofolate synthetase
Biochim. Biophys. Acta
1296
112-130
1996
Clostridium cylindrosporum
Lewinski, K.; Hui, Y.; Jakob, C.G.; Lovell, C.R.; Lebioda, L.
Crystallization and preliminary crystallographic data for formyltetrahydrofolate synthetase from Clostridium thermoaceticum
J. Mol. Biol.
229
1153-1156
1993
Moorella thermoacetica
Mejillano, M.R.; Jahansouz, H.; Matsunaga, T.O.; Kenyon, G.L.; Himes, R.H.
Formation and utilization of formyl phosphate by N10-formyltetrahydrofolate synthetase: evidence for formyl phosphate as an intermediate in the reaction
Biochemistry
28
5136-5145
1989
Saccharomyces cerevisiae, Clostridium cylindrosporum
Lovell, C.R.; Przybyla, A.; Ljungdahl, L.G.
Primary structure of the thermostable formyltetrahydrofolate synthetase from Clostridium thermoaceticum
Biochemistry
29
5687-5694
1990
Moorella thermoacetica
Kirk, C.D.; Imeson, H.C.; Zheng, L.L.; Cossins, E.A.
The affinity of pea cotyledon 10-formyltetrahydrofolate synthetase for polyglutamate substrates
Phytochemistry
35
291-296
1994
Pisum sativum
-
Strong, W.B.; Schirch, V.
In vitro conversion of formate to serine: effect of tetrahydropteroylpolyglutamates and serine hydroxymethyltransferase on the rate of 10-formyltetrahydrofolate synthetase
Biochemistry
28
9430-9439
1989
Oryctolagus cuniculus
Whitehead, T.R.; Park, M.; Rabinowitz, J.C.
Distribution of 10-formyltetrahydrofolate synthetase in eubacteria
J. Bacteriol.
170
995-997
1988
Bacillus subtilis, Bacteroides fragilis, Moraxella catarrhalis, Clostridium sardiniense, Clostridium acidi-urici, Clostridium pasteurianum, Enterococcus faecalis, Eubacterium sp., Micrococcus luteus, Mycolicibacterium smegmatis, Peptostreptococcus anaerobius, Proteus mirabilis, Staphylococcus epidermidis, Eubacterium sp. VPI 12708, Clostridium acidi-urici 9a, Proteus mirabilis 25433, Micrococcus luteus 4698, Enterococcus faecalis 19433, Bacillus subtilis W168, Staphylococcus epidermidis 14990, Peptostreptococcus anaerobius 27337
DAri, L.; Cheung, E.; Rabinowitz, J.C.; Bolduc, J.M.; Huang, J.Y.; Stoddard, B.L.
Purification, crystallization, and preliminary X-ray studies of 10-formyltetrahydrofolate synthetase from Clostridia acidi-urici
Proteins Struct. Funct. Genet.
27
319-321
1997
Clostridium acidi-urici
Villar, E.; Schuster, B.; Peterson, D.; Schirch, V.
C1-Tetrahydrofolate synthase from rabbit liver. Structural and kinetic properties of the enzyme and its two domains
J. Biol. Chem.
260
2245-2252
1985
Oryctolagus cuniculus
Leaphart, A.B.; Trent Spencer, H.; Lovell, C.R.
Site-directed mutagenesis of a potential catalytic and formyl phosphate binding site and substrate inhibition of N10-formyltetrahydrofolate synthetase
Arch. Biochem. Biophys.
408
137-143
2002
Moorella thermoacetica
Radfar, R.; Leaphart, A.; Brewer, J.M.; Minor, W.; Odom, J.D.; Dunlap, R.B.; Lovell, C.R.; Lebioda, L.
Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica
Biochemistry
39
14481-14486
2000
Moorella thermoacetica (P21164), Moorella thermoacetica
Radfar, R.; Shin, R.; Sheldrick, G.M.; Minor, W.; Lovell, C.R.; Odom, J.D.; Dunlap, R.B.; Lebioda, L.
The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica
Biochemistry
39
3920-3926
2000
Moorella thermoacetica (P21164)
Hol, F.A.; van der Put, N.M.; Geurds, M.P.; Heil, S.G.; Trijbels, F.J.; Hamel, B.C.; Mariman, E.C.; Blom, H.J.
Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate-dehydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate synthetase) in patients with neural tube defects
Clin. Genet.
53
119-125
1998
Homo sapiens
Martinasevic, M.K.; Rios, G.R.; Miller, M.W.; Tephly, T.R.
Folate and folate-dependent enzymes associated with rat CNS development
Dev. Neurosci.
21
29-35
1999
Rattus norvegicus
Howard, K.M.; Muga, S.J.; Zhang, L.; Thigpen, A.E.; Appling, D.R.
Characterization of the rat cytoplasmic C1-tetrahydrofolate synthase gene and analysis of its expression in liver regeneration and fetal development
Gene
319
85-97
2003
Rattus norvegicus
Marx, C.J.; Laukel, M.; Vorholt, J.A.; Lidstrom, M.E.
Purification of the formate-tetrahydrofolate ligase from Methylobacterium extorquens AM1 and demonstration of its requirement for methylotrophic growth
J. Bacteriol.
185
7169-7175
2003
Methylorubrum extorquens (Q83WS0), Methylorubrum extorquens ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1 (Q83WS0)
Prasannan, P.; Pike, S.; Peng, K.; Shane, B.; Appling, D.R.
Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls
J. Biol. Chem.
278
43178-43187
2003
Homo sapiens (Q6UB35), Homo sapiens
Walkup, A.S.; Appling, D.R.
Enzymatic characterization of human mitochondrial C1-tetrahydrofolate synthase
Arch. Biochem. Biophys.
442
196-205
2005
Homo sapiens
Sugiura, T.; Nagano, Y.; Inoue, T.; Hirotani, K.
A novel mitochondrial C1-tetrahydrofolate synthetase is upregulated in human colon adenocarcinoma
Biochem. Biophys. Res. Commun.
315
204-211
2004
Homo sapiens (Q6UB35), Homo sapiens
Christensen, K.E.; Patel, H.; Kuzmanov, U.; Mejia, N.R.; MacKenzie, R.E.
Disruption of the mthfd1 gene reveals a monofunctional 10-formyltetrahydrofolate synthetase in mammalian mitochondria
J. Biol. Chem.
280
7597-7602
2005
Mus musculus (Q922D8)
Pester, M.; Brune, A.
Expression profiles of fhs (FTHFS) genes support the hypothesis that spirochaetes dominate reductive acetogenesis in the hindgut of lower termites
Environ. Microbiol.
8
1261-1270
2006
Reticulitermes santonensis, Cryptotermes secundus, Zootermopsis nevadensis
Parle-McDermott, A.; Kirke, P.N.; Mills, J.L.; Molloy, A.M.; Cox, C.; OLeary, V.B.; Pangilinan, F.; Conley, M.; Cleary, L.; Brody, L.C.; Scott, J.M.
Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population
Eur. J. Hum. Genet.
14
768-772
2006
Homo sapiens (P11586)
Prasannan, P.; Appling, D.R.
Human mitochondrial C(1)-tetrahydrofolate synthase: Submitochondrial localization of the full-length enzyme and characterization of a short isoform
Arch. Biochem. Biophys.
481
86-93
2008
Homo sapiens, Rattus norvegicus
Slopien, R.; Jasniewicz, K.; Meczekalski, B.; Warenik-Szymankiewicz, A.; Lianeri, M.; Jagodzinski, P.P.
Polymorphic variants of genes encoding MTHFR, MTR, and MTHFD1 and the risk of depression in postmenopausal women in Poland
Maturitas
61
252-255
2008
Homo sapiens
Christensen, K.E.; Rohlicek, C.V.; Andelfinger, G.U.; Michaud, J.; Bigras, J.L.; Richter, A.; Mackenzie, R.E.; Rozen, R.
The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects
Hum. Mutat.
30
212-220
2009
Homo sapiens (P11586)
Murta, S.M.; Vickers, T.J.; Scott, D.A.; Beverley, S.M.
Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major
Mol. Microbiol.
71
1386-1401
2009
Leishmania major
Christensen, K.E.; Mackenzie, R.E.
Mitochondrial methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase, and formyltetrahydrofolate synthetases
Vitam. Horm.
79
393-410
2008
Homo sapiens, Saccharomyces cerevisiae (P07245), Saccharomyces cerevisiae (P09440)
Xu, K.; Liu, H.; Du, G.; Chen, J.
Real-time PCR assays targeting formyltetrahydrofolate synthetase gene to enumerate acetogens in natural and engineered environments
Anaerobe
15
204-213
2009
Clostridium perfringens, Sphingomonas paucimobilis, Mesorhizobium loti, Rhizobium leguminosarum, Sinorhizobium meliloti, Treponema denticola, Mesorhizobium sp., Sinorhizobium medicae, Desulfovibrio piger, Rhodobacterales, Gottschalkia acidurici (P13419), Moorella thermoacetica (P21164), Acetobacterium carbinolicum (Q15K82), Treponema primitia (Q8GIN9), Eubacterium limosum (Q8GJ02), Eubacterium limosum (Q9AHR7), Acetobacterium psammolithicum (Q8GMP9), Caldanaerobacter subterraneus subsp. tengcongensis (Q8R7L3), Sporomusa termitida (Q9AHR4), Sporomusa ovata (Q9AHR5), Blautia producta (Q9AHR6), Clostridium aceticum (Q9AHR8), Thermoanaerobacter kivui (Q9AHR9), Clostridium formicaceticum (Q9AHS1), Acetobacterium woodii (Q9AHS2), Thermoplasma acidophilum (Q9HI67), Mesorhizobium sp. BNC1
Henderson, G.; Naylor, G.E.; Leahy, S.C.; Janssen, P.H.
Presence of novel, potentially homoacetogenic bacteria in the rumen as determined by analysis of formyltetrahydrofolate synthetase sequences from ruminants
Appl. Environ. Microbiol.
76
2058-2066
2010
Clostridium sp., Eubacterium sp., Clostridium magnum, Sporomusa ovata, Acetitomaculum ruminis, Blautia sp. Ser5, Oxobacter pfennigii, Blautia sp. Ser8, Acetobacterium woodii (Q9AHS2)
Pike, S.T.; Rajendra, R.; Artzt, K.; Appling, D.R.
Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos
J. Biol. Chem.
285
4612-4620
2010
Mus musculus (Q3V3R1), Mus musculus
Christensen, K.E.; Deng, L.; Leung, K.Y.; Arning, E.; Bottiglieri, T.; Malysheva, O.V.; Caudill, M.A.; Krupenko, N.I.; Greene, N.D.; Jerome-Majewska, L.; MacKenzie, R.E.; Rozen, R.
A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development
Hum. Mol. Genet.
22
3705-3719
2013
Mus musculus
Hori, T.; Sasaki, D.; Haruta, S.; Shigematsu, T.; Ueno, Y.; Ishii, M.; Igarashi, Y.
Detection of active, potentially acetate-oxidizing syntrophs in an anaerobic digester by flux measurement and formyltetrahydrofolate synthetase (FTHFS) expression profiling
Microbiology
157
1980-1989
2011
uncultured microorganism (A7BK03), uncultured microorganism (A7BK04), uncultured microorganism (A7BK05), uncultured microorganism (A7BK06), uncultured microorganism (A7BK07), uncultured microorganism (A7BK08), uncultured microorganism (A7BK09), uncultured microorganism (A7BK10), uncultured microorganism (A7BK11), uncultured microorganism (A7BK12), uncultured microorganism (A7BK13), uncultured microorganism (A7BK14), uncultured microorganism (A7BK15), uncultured microorganism (A7BK16), uncultured microorganism (A7BK17), Thermacetogenium phaeum (D4QDA0), Thermacetogenium phaeum, Thermacetogenium phaeum DSM 12270 (D4QDA0)
Celeste, L.R.; Chai, G.; Bielak, M.; Minor, W.; Lovelace, L.L.; Lebioda, L.
Mechanism of N10-formyltetrahydrofolate synthetase derived from complexes with intermediates and inhibitors
Protein Sci.
21
219-228
2012
Moorella thermoacetica (P21164), Moorella thermoacetica
Sah, S.; Aluri, S.; Rex, K.; Varshney, U.
One-carbon metabolic pathway rewiring in Escherichia coli reveals an evolutionary advantage of 10-formyltetrahydrofolate synthetase (Fhs) in survival under hypoxia
J. Bacteriol.
197
717-726
2015
Clostridium perfringens (Q0TMI3), Clostridium perfringens, Clostridium perfringens DSM 756 (Q0TMI3)
Aluri, S.; Sah, S.; Miryala, S.; Varshney, U.
Physiological role of FolD (methylenetetrahydrofolate dehydrogenase), FchA (methenyltetrahydrofolate cyclohydrolase) and Fhs (formyltetrahydrofolate synthetase) from Clostridium perfringens in a heterologous model of Escherichia coli
Microbiology
162
145-155
2016
Clostridium perfringens, Clostridium perfringens (Q0TMI3), Clostridium perfringens DSM 756 (Q0TMI3)
Sah, S.; Varshney, U.
Impact of mutating the key residues of a bifunctional 5,10-methylenetetrahydrofolate dehydrogenase-cyclohydrolase from Escherichia coli on its activities
Biochemistry
54
3504-3513
2015
Clostridium perfringens
Lee, D.; Xu, I.M.; Chiu, D.K.; Lai, R.K.; Tse, A.P.; Lan Li, L.; Law, C.T.; Tsang, F.H.; Wei, L.L.; Chan, C.Y.; Wong, C.M.; Ng, I.O.; Wong, C.C.
Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma
J. Clin. Invest.
127
1856-1872
2017
Homo sapiens (Q6UB35)
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