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Literature summary for 6.3.4.3 extracted from

  • Cossins, E.A.; Kirk, C.D.; Imeson, H.C.; Zheng, L.l.
    Enzymes for synthesis of 10-formyltetrahydrofolate in plants. Characterization of a monofunctional 10-formyltetrahydrofolate synthetase and copurification of 5,10-methylenetetrahydrofolate dehydrogenase and 5,10-methenyltetrahydrofolate cyclohydrolase activities (1993), Adv. Exp. Med. Biol., 338, 707-710.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003
-
 5,6,7,8-tetrahydropteroylpentaglutamate
-
 Pisum sativum
0.012
-
 ATP reaction with tetrahydropteroyl-Glu5 Pisum sativum
0.04
-
 tetrahydrofolate
-
 Pisum sativum
0.094
-
 ATP reaction with tetrahydrofolate Pisum sativum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
56000
-
 2 * 56000, SDS-PAGE Pisum sativum
110000
-
 gel filtration Pisum sativum

Organism

Organism UniProt Comment Textmining
Pisum sativum
-
 monofunctional enzyme
-

Purification (Commentary)

Purification (Comment) Organism
-
 Pisum sativum

Source Tissue

Source Tissue Comment Organism Textmining
cotyledon
-
 Pisum sativum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + formate + 5,6,7,8-tetrahydropteroylpentaglutamate
-
 Pisum sativum ADP + phosphate + 10-formyltetrahydrofolylpentaglutamate
-
 ?
ATP + formate + tetrahydrofolate
-
 Pisum sativum ADP + phosphate + 10-formyltetrahydrofolate
-
 ?
ATP + formate + tetrahydropteroyl-(Glu)n n: 1-5 Pisum sativum ADP + phosphate + 10-formyltetrahydropteroyl-(Glu)n
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 56000, SDS-PAGE Pisum sativum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Pisum sativum