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Literature summary for 6.3.4.3 extracted from

  • Buttlaire, D.H.; Balfe, C.A.; Wendland, M.F.; Himes, R.H.
    Carbamyl phosphate-dependent ATP synthesis catalyzed by formyltetrahydrofolate synthetase (1979), Biochim. Biophys. Acta, 567, 453-463.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
acetyl phosphate inhibits ATP synthesis reaction from carbamoyl phosphate and ADP, and synthesis of 10-formyltetrahydrofolate Clostridium cylindrosporum
Carbamoyl phosphate
-
Clostridium cylindrosporum
formate inhibits ATP synthesis reaction from carbamoyl phosphate and ADP Clostridium cylindrosporum
phosphate inhibits ATP synthesis reaction from carbamoyl phosphate and ADP Clostridium cylindrosporum
Phosphonoacetate inhibits ATP synthesis reaction from carbamoyl phosphate and ADP, and synthesis of 10-formyltetrahydrofolate Clostridium cylindrosporum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.032
-
ADP ATP synthesis from carbamoylphosphate Clostridium cylindrosporum
0.032 0.077 tetrahydrofolate ATP synthesis Clostridium cylindrosporum
0.13
-
ADP formyltetrahydrofolate synthesis Clostridium cylindrosporum
0.27
-
tetrahydrofolate formyltretrahydrofolate synthesis Clostridium cylindrosporum
11.9
-
Carbamoyl phosphate
-
Clostridium cylindrosporum

Organism

Organism UniProt Comment Textmining
Clostridium cylindrosporum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + formate + tetrahydrofolate r Clostridium cylindrosporum ADP + phosphate + 10-formyltetrahydrofolate
-
?
Carbamoyl phosphate + ADP
-
Clostridium cylindrosporum ? + ATP
-
?