5.4.99.B22: multisite-specific tRNA pseudouridine synthase
This is an abbreviated version!
For detailed information about multisite-specific tRNA pseudouridine synthase, go to the full flat file.
Word Map on EC 5.4.99.B22
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5.4.99.B22
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pseudouridylation
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anemia
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sideroblastic
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myopathy
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dyskerin
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anticodon
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mlasa
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spliceosomal
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nuclear-encoded
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agriculture
- 5.4.99.B22
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pseudouridylation
- anemia
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sideroblastic
- myopathy
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dyskerin
-
anticodon
-
mlasa
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spliceosomal
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nuclear-encoded
- agriculture
Reaction
Synonyms
cePus1p, dmPus1p, hPus1p, mPus1p, pseudouridine synthase 1, pseudouridine synthase Pus10, PUS1, Pus1p, Pus4, PUS6, PUS7, RluE, RNA:pseudouridine synthases 1, RPUSD4, scPus1p, spPus1p, SVR1, TgPUS1, xtPus1p, YmfC
ECTree
5.4.99.B22 multisite-specific tRNA pseudouridine synthaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 5.4.99.B22 - multisite-specific tRNA pseudouridine synthase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
mitochondrial tRNAPhe uridine39
mitochondrial tRNAPhe pseudouridine39
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?
23S rRNA uridine2457
23S rRNA pseudouridine2457
RluE forms a highly conserved pseudouridine during ribosome biogenesis
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?
23S rRNA uridine2457
23S rRNA pseudouridine2457
RluE forms a highly conserved pseudouridine during ribosome biogenesis
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?
KAR2 mRNA uridine
KAR2 mRNA pseudouridine
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?
KAR2 mRNA uridine
KAR2 mRNA pseudouridine
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?
RPL11a mRNA uridine68
RPL11a mRNA pseudouridine68
the Pus1 enzyme is necessary and sufficient for pseudouridylation of RPL11a mRNA
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?
RPL11a mRNA uridine68
RPL11a mRNA pseudouridine68
the Pus1 enzyme is necessary and sufficient for pseudouridylation of RPL11a mRNA
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?
TEF1 mRNA uridine239
TEF1 mRNA pseudouridine239
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?
TEF1 mRNA uridine239
TEF1 mRNA pseudouridine239
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?
additional information
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Pus1p catalyzes the formation of pseudouridines in several positions and in a number of different tRNA species
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?
additional information
?
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Pus1p catalyzes the formation of pseudouridines in several positions and in a number of different tRNA species
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?
additional information
?
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for tRNA and Pus7, many known sites and their associated modifiers are identified, including Pus1-mediated Psi sites at positions 26-28 in several tRNAs, Pus7-dependent sites at position 13 of glutamate tRNA, Pus9-dependent site in mitochondrial aspartate tRNA at position 32, and Deg1-dependent sites at positions 37-38 in several tRNAs. Pseudouridylation in ncRNAs at sites of inter or intra-molecular interactions
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?
additional information
?
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Pus1p is the only pseudouridine synthase in Saccharomyces cerevisiae that is active on U2 snRNA at position 44. Yeast U2 snRNA is normally pseudouridylated at positions 35, 42, and 44
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?
additional information
?
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Pus1p is the only pseudouridine synthase in Saccharomyces cerevisiae that is active on U2 snRNA at position 44. Yeast U2 snRNA is normally pseudouridylated at positions 35, 42, and 44
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?
additional information
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extensive, regulated pseudouridylation of Toxoplasma mRNA with evidence for 1669 and 394 sites of pseudouridylation in tachyzoite and bradyzoite mRNAs, respectively. The distribution of Us and Psis is significantly different between the three regions of the transcript. Pseudouridylation is underrepresented in the 3'-UTR. At least in tachyzoites, TgPUS1-dependent Psis are distributed within the codon comparably toTgPUS1-independent Psis
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?
additional information
?
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extensive, regulated pseudouridylation of Toxoplasma mRNA with evidence for 1669 and 394 sites of pseudouridylation in tachyzoite and bradyzoite mRNAs, respectively. The distribution of Us and Psis is significantly different between the three regions of the transcript. Pseudouridylation is underrepresented in the 3'-UTR. At least in tachyzoites, TgPUS1-dependent Psis are distributed within the codon comparably toTgPUS1-independent Psis
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?
