5.3.99.5: thromboxane-A synthase
This is an abbreviated version!
For detailed information about thromboxane-A synthase, go to the full flat file.
Word Map on EC 5.3.99.5
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5.3.99.5
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platelet
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prostaglandin
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arachidonic
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artery
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cyclooxygenase
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prostacyclin
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indomethacin
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endothelial
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endoperoxide
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pulmonary
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prostanoids
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aspirin
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dazoxiben
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coronary
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eicosanoids
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vasoconstrictor
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leukotriene
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imidazole
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hypertension
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thrombosis
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aorta
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hemodynamic
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antiplatelet
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6-keto-pgf1
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cox-2
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5-lipoxygenase
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6-keto-prostaglandin
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vasodilator
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antithrombotic
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ozagrel
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endothelium-dependent
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thrombus
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paf
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endothelium-derived
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bronchoconstriction
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6-keto
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platelet-rich
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constrictor
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collagen-induced
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aa-induced
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analysis
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medicine
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aspirin-treated
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pharmacology
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ticlopidine
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reocclusion
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meclofenamate
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f1alpha
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pgg2
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iloprost
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antiaggregatory
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14c-arachidonic
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proaggregatory
- 5.3.99.5
- platelet
- prostaglandin
-
arachidonic
- artery
-
cyclooxygenase
- prostacyclin
- indomethacin
- endothelial
-
endoperoxide
- pulmonary
-
prostanoids
- aspirin
- dazoxiben
- coronary
-
eicosanoids
-
vasoconstrictor
-
leukotriene
- imidazole
- hypertension
- thrombosis
- aorta
-
hemodynamic
-
antiplatelet
-
6-keto-pgf1
- cox-2
-
5-lipoxygenase
-
6-keto-prostaglandin
-
vasodilator
-
antithrombotic
- ozagrel
-
endothelium-dependent
- thrombus
- paf
-
endothelium-derived
-
bronchoconstriction
-
6-keto
-
platelet-rich
-
constrictor
-
collagen-induced
-
aa-induced
- analysis
- medicine
-
aspirin-treated
- pharmacology
- ticlopidine
-
reocclusion
- meclofenamate
-
f1alpha
- pgg2
-
iloprost
-
antiaggregatory
-
14c-arachidonic
-
proaggregatory
Reaction
Synonyms
CYP5A1, Synthetase, thromboxane, TBXAS1, Thromboxan synthetase, thromboxane A synthase 1, thromboxane A-synthase, thromboxane A2 synthase, thromboxane A2 synthase 1, Thromboxane A2 synthetase, thromboxane synthase, Thromboxane synthetase, TXA synthase, TxA-synthase, TXA2 synthase, TXAS, TXS, TXSA, TxSI
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General Information
General Information on EC 5.3.99.5 - thromboxane-A synthase
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malfunction
physiological function
additional information
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inhibition of thromboxane synthase induces lung cancer cell death via increasing the nuclear p27
malfunction
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enzyme inhibition induces cell death in vitro. Selective TXS inhibition significantly reduces tumour cell growth and increases apoptosis, while TXS overexpression stimulates cell proliferation and invasiveness, and is protective against apoptosis, quantification of multi-parameter apoptosis signalling, overview
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the enzyme is a membrane-associated cytochrome P450 that metabolizes the cyclooxygenase product prostaglandin into thromboxane A2, a potent inducer of vasoconstriction and platelet aggregation
physiological function
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thromboxane synthase metabolises prostaglandin H2 into thromboxanes, which are biologically active on cancer cells. TXS overexpression occurs in a range of cancers, and associated with a poor prognosis, although in non-small lung cancer cells, no significant correlation with patient survival is observed
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role of membranes in modulating the thermodynamics and kinetics of enzyme substrate binding, redox potential of enzyme incorporated into lipid bilayers of nanodiscs, overview. Binding of substrate to the enzyme can induce conformational changes in the protein that block small-molecule ligand egress
additional information
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the adaptive active site in the enzyme might be capable of binding multiple ligands simultaneously because of its large size and flexibility. Ligand and substrate binding structure, competitive binding experiments with Nile Red, a fluorescence dye, and 2-p-toluidinylnaphthalene-6-sulfonic acid, and the computer-simulated TXAS structure with clotrimazole as a heme ligand, molecular dynamics simulations of clotrimazole and 2-p-toluidinylnaphthalene-6-sulfonic acid-docking enzyme, overview