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(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9a,11a-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
12-L-hydroxy-5,8,10-heptadecaotrienoic acid + malondialdehyde
15(S)-Hydroxy-11alpha,9alpha-epoxymethano-5(Z),13(E)-prostadienoic acid
?
-
in presence of iodosylbenzene
3 different hydroxylated derivatives of 15(S)-hydroxy-11alpha,9alpha-epoxymethano-5(Z),13(E)-prostadienoic acid
?
15-hydroperoxyeicosatetraenoic acid
13-hydroxy-14,15-epoxy-5,8,11-eicosatrienoic acid + 15-ketoeicosatetraenoic acid + 13-hydroxy-14,15-epoxy-5,8,11-eicosatrienoic acid + 15-ketoeicosatetraenoic acid
-
-
13-hydroxy-14,15-epoxy-5,8,11-eicosatrienoic acid and 15-ketoeicosatetraenoic acid result from homolytic cleavage of the O-O bond, whereas 13-hydroxy-14,15-epoxy-5,8,11-eicosatrienoic acid + 15-ketoeicosatetraenoic acid results from heterolytic cleavage. About 60% of substrate is cleaved homolytically, and maximal velocity of homolytic cleavage is about 1.4fold faster than heterolytic cleavage
-
?
15-hydroxy-9alpha,11alpha-peroxiprosta-5,13-dienoic acid
?
-
-
-
-
?
15-Ketoprostaglandin H2
?
-
-
-
-
?
2 prostaglandin G2
15-hydroperoxythromboxane A2 + 12-hydroperoxy-5,8,10-heptadecatrienoic acid
-
i.e. PGG2
the reaction products are transformed to thromboxane B2 and 12-hydroxy-5,8,10-heptadecatrienoic acid by SnCl2 reduction and to 12-keto-5,8,10-heptadecatrienoic acid and 15-ketothromboxane B2 by lead tetraacetate dehydration
?
2 prostaglandin G2 + H2O
15-hydroperoxythromboxane B2 + 12-hydroperoxy-5,8,10-heptadecatrienoic acid
2 prostaglandin H3 + H2O
thromboxane B3 + 12(L)-hydroxy-5,8,10,14-heptadecatetraenoic acid + malondialdehyde
-
-
the ratio of thromboxane to C17 hydroxyfatty acid formation is 1:1. Thromboxane A2 is fully transformed to thromboxane B2
?
8-Isoprostaglandin H2
8-cis-12-Hydroperoxy-5,8,10-heptadecatrienoic acid
-
-
-
?
prostaglandin E2
thromboxane A2 + ?
-
-
thromoboxane A2 is non-enzymatically converted to thromboxane B2, which is secretion is measured to analyze the enzyme activity
-
?
prostaglandin H1
12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1
prostaglandin H2
thromboxane A2
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
prostaglandin H2
thromboxane B2 + 12(S)-hydroxy-5,8,10-heptadecatrienoic acid
Prostaglandin H3
Thromboxane B3 + DELTA14-12-hydroperoxy-5,8,10-heptadecatrienoic acid
-
-
-
?
additional information
?
-
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
12-L-hydroxy-5,8,10-heptadecaotrienoic acid + malondialdehyde
-
-
ratio of TXA2/heptadecatrienoic acid/malondialdehyde, 1/1/1
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
12-L-hydroxy-5,8,10-heptadecaotrienoic acid + malondialdehyde
-
-
ratio of TXA2/heptadecatrienoic acid/malondialdehyde, 1/1/1
?
2 prostaglandin G2 + H2O
15-hydroperoxythromboxane B2 + 12-hydroperoxy-5,8,10-heptadecatrienoic acid
-
i.e. PGG2
-
-
?
2 prostaglandin G2 + H2O
15-hydroperoxythromboxane B2 + 12-hydroperoxy-5,8,10-heptadecatrienoic acid
-
i.e. PGG2
-
?
2 prostaglandin G2 + H2O
15-hydroperoxythromboxane B2 + 12-hydroperoxy-5,8,10-heptadecatrienoic acid
-
i.e. PGG2
-
?
prostaglandin H1
12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1
-
-
-
-
?
prostaglandin H1
12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1
-
-
thromboxane B1 is scarcely detectable, the major product is 12(L)-hydroxy-8,10-heptadecadienoic acid
?
prostaglandin H1
12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1
-
activity is equal to that with prostaglandin H2
thromboxane B1 is scarcely detectable, the major product is 12(L)-hydroxy-8,10-heptadecadienoic acid
?
prostaglandin H1
12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1
-
-
-
?
prostaglandin H1
12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1
-
-
thromboxane B2 is not mentioned as product
?
prostaglandin H1
12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1
-
-
thromboxane B1 is scarcely detectable, the major product is 12(L)-hydroxy-8,10-heptadecadienoic acid
?
prostaglandin H1
12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1
-
-
thromboxane B1 is scarcely detectable, the major product is 12(L)-hydroxy-8,10-heptadecadienoic acid
?
prostaglandin H1
12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1
-
poor substrate
-
-
?
prostaglandin H2
thromboxane A2
-
-
-
-
?
prostaglandin H2
thromboxane A2
-
-
-
-
?
prostaglandin H2
thromboxane A2
-
-
-
-
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
-
-
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
-
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
-
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
-
-
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
-
-
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
-
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
-
-
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
-
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
3179, 3180, 3183, 3185, 3186, 3187, 3188, 3189, 3190, 3192, 3193, 3195, 3197, 3198 -
-
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
-
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
-
-
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
the thromboxane A2 that is formed by the enzyme is transformed to thromboxane B2
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
the thromboxane A2 that is formed by the enzyme is transformed to thromboxane B2
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
+ malondialdehyde
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
+ malondialdehyde
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
the ratio of thromboxane to C17 hydroxyfatty acid formation is 1:1
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
the ratio of thromboxane to C17 hydroxyfatty acid formation is 1:1
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
the ratio of thromboxane to C17 hydroxyfatty acid formation is 1:1
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
thromboxane A2 is an intermediate
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
-
-
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
-
-
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
-
-
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
-
-
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
-
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
-
?
Prostaglandin H2
thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
i.e. PGH2
the ratio of 12-hydroxy-5,8,10-heptadecatrienoic acid to thromboxane B2 varries from 1.6 to 2.1 depending on the reaction conditions
?
prostaglandin H2
thromboxane B2 + 12(S)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
-
-
?
prostaglandin H2
thromboxane B2 + 12(S)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
-
-
?
prostaglandin H2
thromboxane B2 + 12(S)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
-
-
?
additional information
?
-
-
production of thromboxane A2, an unstable bioregulator that induces platelet release reaction, platelet aggregation and smooth muscle contraction
-
-
?
additional information
?
-
-
cyclooxygenase-2 and thromboxane synthase are involved in the diosgenin-induced megakaryocytic differentiation in HEL cells
for analysis of the thromboxane synthase activity the secretion of thromoxane B2 is measured. Thromboxane B2 is a nonenzymatic conversion product of thromobxane A1, the product of the thromboxane synthase activity
-
?
additional information
?
-
-
TXAS is one of the terminal enzymes of the arachidonic acid cascade and converts prostaglandins H2 into thromobane A2 in the endoplasmic reticulum
-
-
?
additional information
?
-
-
thromboxane A2 synthase catalyzes an isomerization of prostaglandins H2 to give rise to thromboxane A2 along with a fragmentation reaction to 12-L-hydroxy-5,8,10-heptadecatrienoic acid and malondialdehyde. 2-p-Toluidinylnaphthalene-6-sulfonic acid is utilized as a probe to assess the spatial relationship and binding dynamics of ligand-enzyme interactions by steady-state and time-resolved fluorescence spectroscopy
-
-
?
additional information
?
-
-
substrate binding analysis using substrate analogues of PGH2, U44069 and U46619
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
12-L-hydroxy-5,8,10-heptadecaotrienoic acid + malondialdehyde
prostaglandin H2
thromboxane A2
prostaglandin H2
thromboxane B2 + 12(S)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
-
-
?
additional information
?
-
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
i.e. TXA2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
12-L-hydroxy-5,8,10-heptadecaotrienoic acid + malondialdehyde
-
-
ratio of TXA2/heptadecatrienoic acid/malondialdehyde, 1/1/1
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
12-L-hydroxy-5,8,10-heptadecaotrienoic acid + malondialdehyde
-
-
ratio of TXA2/heptadecatrienoic acid/malondialdehyde, 1/1/1
?
prostaglandin H2
thromboxane A2
-
-
-
-
?
prostaglandin H2
thromboxane A2
-
-
-
-
?
prostaglandin H2
thromboxane A2
-
-
-
-
?
additional information
?
-
-
production of thromboxane A2, an unstable bioregulator that induces platelet release reaction, platelet aggregation and smooth muscle contraction
-
-
?
additional information
?
-
-
cyclooxygenase-2 and thromboxane synthase are involved in the diosgenin-induced megakaryocytic differentiation in HEL cells
for analysis of the thromboxane synthase activity the secretion of thromoxane B2 is measured. Thromboxane B2 is a nonenzymatic conversion product of thromobxane A1, the product of the thromboxane synthase activity
-
?
additional information
?
-
-
TXAS is one of the terminal enzymes of the arachidonic acid cascade and converts prostaglandins H2 into thromobane A2 in the endoplasmic reticulum
-
-
?
additional information
?
-
-
thromboxane A2 synthase catalyzes an isomerization of prostaglandins H2 to give rise to thromboxane A2 along with a fragmentation reaction to 12-L-hydroxy-5,8,10-heptadecatrienoic acid and malondialdehyde. 2-p-Toluidinylnaphthalene-6-sulfonic acid is utilized as a probe to assess the spatial relationship and binding dynamics of ligand-enzyme interactions by steady-state and time-resolved fluorescence spectroscopy
-
-
?
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(+)-(E)-7-[4-[4-[[[2-(trans)-phenylcyclopropyl]amino]carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridyl)hept-6-enoic acid
-
0.0000085 mM, 50% inhibition
(+)-5-(2-imidazole-1-ethyloxy)-1-indan-carboxylic acid
-
trivial name camonagrel
(+/-)-6-(1-Imidazolylmethyl)-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid hydrochloride hemihydrate
-
improvement of the renal function with the selective thromboxane A2 synthetase inhibitor
(-)-(E)-7-[4-[4-[[[2-(trans)-phenylcyclopropyl]amino]carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridyl)hept-6-enoic acid
-
0.0000059 mM, 50% inhibition
(5E)-6-(3-(2-cyano-3,3-dimethyl)guanidinophenyl)-6-(3-pyridyl)hex-5-enoic acid
-
0.000026 mM, 50% inhibition
(5E)-6-(3-(2-cyano-3-(1-adamantyl)-guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid
-
0.000003 mM, 50% inhibition
(5E)-6-(3-(2-cyano-3-(2-dimethylaminoethyl)-guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid
-
0.0029 mM, 50% inhibition
(5E)-6-(3-(2-cyano-3-(2-methylpropyl)guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid
-
0.000025 mM, 50% inhibition
(5E)-6-(3-(2-cyano-3-(3-methylbutyl)guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid
-
0.000003 mM, 50% inhibition
(5E)-6-(3-(2-cyano-3-(3-pyridylmethyl)-guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid
-
0.000032 mM, 50% inhibition
(5E)-6-(3-(2-cyano-3-benzylguanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid
-
0.000011 mM, 50% inhibition
(5E)-6-(3-(2-cyano-3-cyclohexyl-guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid
-
0.000003 mM, 50% inhibition
(5E)-6-(3-(2-cyano-3-cyclopentyl-guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid
-
0.000003 mM, 50% inhibition
(5E)-6-(3-(2-cyano-3-cyclopropyl-guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid
-
0.00038 mM, 50% inhibition
(5E)-6-(3-(2-cyano-3-isopropyl)guanidinophenyl)-6-(3-pyridyl)hex-5-enoic acid
-
0.000024 mM, 50% inhibition
(5E)-6-(3-(2-cyano-3-methyl)guanidinophenyl)-6-(3-pyridyl)hex-5-enoic acid
-
0.00025 mM, 50% inhibition
(5E)-6-(3-(2-cyano-3-tert-butyl-guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid
-
0.000004 mM, 50% inhibition
(5E)-6-(4-(2-cyano-3-cyclopentyl-guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid
-
0.00018 mM, 50% inhibition
(5E)-6-(4-(2-cyano-3-cyclopropyl-guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid
-
0.0039 mM, 50% inhibition
(5Z)-6-[(2S,4R)-4-(4-Chlorophenylsulphonylamino)-1-(3-pyridylmethyl)-2-pyrrolidinyl]-5-hexenoic acid hydrochloride
-
thromboxane A2 synthetase inhibitor/thromboxane A2-receptor antagonist
(E)-3-[4-(1-Imidazolylmethyl)phenyl]-2-propenoate
-
reversible
(E)-6-[4-(3-tert-butyl-2-cyanoguanidino)phenyl]-6-(3-pyridyl)hex-5-enoic acid
-
trivial name terbogrel
(E)-7-[4-[4-[(benzylamino)carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridyl)hept-6-enoic acid
-
0.000025 mM, 50% inhibition
(E)-7-[4-[4-[(pentylamino)carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridiyl)hept-6-enoic acid
-
0.000031 mM, 50% inhibition
(E)-7-[4-[4-[(phenylethylamino)carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridyl)hept-6-enoic acid
-
0.0000094 mM, 50% inhibition
(E)-7-[4-[4-[[(2-phenoxybutyl)amino]carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridyl)hept-6-enoic acid
-
0.000049 mM, 50% inhibition
(E)-7-[4-[4-[[(2-phenoxyethyl)amino]carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridyl)hept-6-enoic acid
-
0.0000026 mM, 50% inhibition
(E)-7-[4-[4-[[(2-phenoxypentyl)amino]carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridyl)hept-6-enoic acid
-
0.000049 mM, 50% inhibition
(E)-7-[4-[4-[[(4-cyclohexylbutyl)amino]carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridyl)hept-6-enoic acid
-
0.000055 mM, 50% inhibition
(E)-7-[4-[4-[[(4-cyclopropylmethyl)amino]carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridyl)hept-6-enoic acid
-
0.000025 mM, 50% inhibition
(E)-7-[4-[4-[[3-(morpholinopropyl)amino]carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridyl)hept-6-enoic acid
-
0.0000051 mM, 50% inhibition
(E)-7-[4-[4-[[[2-(benzyloxy)ethyl]amino]carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridyl)hept-6-enoic acid
-
0.000048 mM, 50% inhibition
(E)-7-[4-[4-[[[2-(cyclohexylmethoxy)ethyl]amino]carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridyl)hept-6-enoic acid
-
0.0000037 mM, 50% inhibition
(E)-7-[4-[4-[[[2-(cyclohexyloxy)ethyl]amino]carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridyl)hept-6-enoic acid
-
0.0000033 mM, 50% inhibition
(E)-7-[4-[4-[[[2-(tetrahydropyran-2-ylmethoxy)ethyl]amino]carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridyl)hept-6-enoic acid
-
0.0000063 mM, 50% inhibition
(E)-7-[4-[4-[[[3-(1-cyclohexylethoxy)propyl]amino]carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridyl)hept-6-enoic acid
-
0.0000012 mM, 50% inhibition
(E)-7-[4-[4-[[[3-(4-methoxyphenyl)propyl]amino]carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridyl)hept-6-enoic acid
-
0.0000027 mM, 50% inhibition
(E)-7-[4-[4-[[[3-(cyclohexyloxy)propyl]amino]carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridyl)hept-6-enoic acid
-
0.0000042 mM, 50% inhibition
(E)-7-[4-[4-[[[3-[(cis)-4-methoxycyclohexyl]propyl]amino]carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridyl)hept-6-enoic acid
-
0.0000029 mM, 50% inhibition
(E)-7-[4-[4-[[[4-(cyclohexyloxy)butyl]amino]carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridyl)hept-6-enoic acid
-
0.0000049 mM, 50% inhibition
([5-[2-([[(1E)-phenyl(pyridin-3-yl)methylidene]amino]oxy)ethyl]-7,8-dihydronaphthalen-1-yl]oxy)acetic acid
-
i.e. ONO-1301, in addition to inhibitory activity, application of ONO-1301 significantly attenuates the development of pulmonary fibrosis and improves survival after treatment with bleomycin
1(omega-Carboxylalkyl)imidazoles
-
very potent
-
1-(2-Isopropylphenyl)-imidazole
-
strong
1-Decylimidazole
-
strong
1-Nonylimidazole
-
strong
1-[2-(4,5,6,7-tetrahydrobenzo[b]furan-4-yl)ethyl]-1H-imidazole
-
0.001 mM, 50% inhibition
1-[2-(4,5,6,7-tetrahydrobenzo[b]furan-4-ylidene)ethyl]-1H-imidazole
-
E isomer, 0.00355 mM, 50% inhibition; Z isomer, 0.0041 mM, 50% inhibition
1-[2-(4,5,6,7-tetrahydrobenzo[b]thiophen-4-yl)ethyl]-1H-imidazole
-
0.0012 mM, 50% inhibition
1-[2-(4,5,6,7-tetrahydrobenzo[b]thiophen-4-ylidene)ethyl]-1H-imidazole
-
E isomer, 0.0017 mM, 50% inhibition; Z isomer, 0.0013 mM, 50% inhibition
1-[2-(benzo[b]thiophen-4-yl)ethyl]-1H-imidazole
-
0.0053 mM, 50% inhibition
1-[3-(4-Benzylhydryl-1-piperazinyl)propyl]-3-(1H-imidazol-1-ylmethyl)-1H-indole-6-carboxylic acid
-
strong thromboxane synthetase inhibition and H1-blocking activity
12L-Hydroperoxy-5,8,10,14-eicosatetraenoic acid
-
0.1 mM, 50% inhibition
15-hydroperoxyeicosatetraenoic acid
-
-
15-Hydroxy-11alpha,9alpha-(epoxymethano)-prosta-5,13-dienoic acid
-
reversible
15-Hydroxy-9alpha,11alpha-peroxidoprosta-5,13-dienoic acid
-
irreversible inactivation during catalysis, protection by (E)-3-[4-(1-imidazolylmethyl)phenyl]-2-propenoate and 15-hydroxy-11alpha,9alpha-(epoxymethano)-prosta-5,13-dienoic acid
1H-Imidazol-1-ylalyl-substituted 3-[2-[(arylsulfonyl)amino]ethyl]benzenepropanoic acid derivatives
-
dual thromboxane synthase inhibitor/thromboxane receptor antagonists
2-Isopropyl-3-nicotinylindole
2-[4-Carboxy-8-(5-imidazol[1,5-a]pyridinyl)octanoyl]-2,3-dihydro-1H-1-isoindole-1-carboxylic acid
-
-
2-[[1-(Carboxymethyl)-2,3,4,5,-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]amino]-6-[[5-[5-chloro-1-methyl-2-(3-pyridinyl)-1H-indol-3-yl]pentanoyl]amino]hexanoic acid
-
-
2-[[1-(Carboxymethyl)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]amino]6-[[5-[5-chloro-1-methyl-2-(3-pyridinyl)-1H-indol-3-yl]pentanoyl](2-hydroxyethyl)amino]hexanoic acid
-
-
2-[[1-(Carboxymethyl)-2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3-yl]amino]-6-[[1-[5-[5-chloro-1-methyl-2-(3-pyridinyl)1H-indol-3-yl]pentanoyl]piperidin-4-yl]amino]hexanoic acid
-
-
2-[[1-(Carboxymethyl)-2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3-yl]amino]-6-[[5-[5-chloro-1-methyl-2-(3-pyridinyl)1H-indol-3-yl]pentanoyl][2-(methylamino)ethyl]amino]hexanoic acid
-
-
2-[[1-(Carboxymethyl)-2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3-yl]amino]-7-[[2-[[5-[5-chloro-1-methyl-2-(3-pyridinyl)1H-indol-3-yl]pentanoyl]amino]ethyl]amino]heptanoic acid
-
-
3-Pyridinylalkyl-substituted 3-[2-[(arylsulfonyl)amino]ethyl]benzenepropanoic acid derivatives
-
dual thromboxane synthase inhibitor/thromboxane receptor antagonists
4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)imidazole
-
trivial name SB203580
4-(Benzylamino)-2-(3'-pyridyl)quinazoline
-
-
4-(Benzylamino)-2-(imidazol-1-yl)-quinazoline
-
-
4-{2-[(4-chlorophenyl)methyl]-3-phenylpropanoyl}phenyl hydrogen benzylphosphonate
5-[2-(imidazol-1-yl)-ethyl]-5,6,7,8-tetrahydroquinoline
-
0.00063 mM, 50% inhibition
5-[2-(imidazol-1-yl)ethyl]-1,2,3,4-tetrahydronaphthalene
-
0.0034 mM, 50% inhibition
5-[2-(imidazol-1-yl)ethyl]-7,8-dihydroquinoline
-
0.00029 mM, 50% inhibition
5-[2-(imidazol-1-yl)ethyl]quinoline
-
0.0012 mM, 50% inhibition
5-[3-(imidazol-1-yl)-propyl]-5,6,7,8-tetrahydroquinoline
-
0.0023 mM, 50% inhibition
5-[3-(imidazol-1-yl)-propyl]-7,8-dihydroquinoline
-
0.00068 mM, 50% inhibition
5-[imidazol-1-yl-methyl]-5,6,7,8-tetrahydroquinoline
-
0.002 mM, 50% inhibition
5-[imidazol-1-yl-methyl]-7,8-dihydroquinoline
-
0.0015 mM, 50% inhibition
5E-6-(3-cyanoguanidino)phenyl-6-(3-pyridyl)hex-5-enoic acid
-
0.00043 mM, 50% inhibition
5Z-6[(2S,4R)-4-(4-Chlorophenylsulfonylamino)-1-(3-pyridylmethyl)-2-pyrrolidinyl]-5-hexenoic acid
-
causes marked improvement in the PGI2/TXA2 ratio in diabetic retinopathy by inhibition of thromboxane synthase
7-[(imidazol-1-yl)methyl]isoquinoline
-
0.0054 mM, 50% inhibition
8-[2-(3-Pyridinyl)-1H-indol-1-yl]octanoic acid 1-(carboxymethyl)-3-[(1-carboxy-3-phenylpropyl)amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-5-yl ester
-
-
9,11(Epoxymethano) prostanoic acid
-
-
9,11-Azo-15-hydroxyprosta-5,13-dienoic acid
-
-
9,11-Azoprosta-5,13 dienoic acid
-
-
9,11-Azoprosta-5,13-dienoic acid
-
-
9,11-Epoxymethano-15-hydroxy-prosta-5,13-dienoic acid
-
-
9alpha,11alpha-Azo-15-(S)Hydroxyprosta-5(cis)-13(trans)-dienoic acid
-
-
9alpha,11alpha-Methanoepoxy-15(S)-hydroxyprosta-5(cis)-13(trans)-dienoic acid
BM 567
-
i.e. 2-(cyclohexylamino)-5-nitro-N-[(pentylamino)carbonyl]-benzenesulfonamide, 10 microM, a specific inhibitor for thromboxane synthase, decrease the acitivity 2.1fold before diosgenin treatment
carboxyheptyl imidazole
-
10 microM, concentration of thromboxane B2 in culture supernatants: reduction of thromboxane B2 in prostate cancer cells PC-3 from 1295 pg/ml to 685 pg/ml, reduction of thromboxane B2 in erythroleukemia cells HEL from 580 pg/ml to 292 pg/ml. In PC-3 cell lysates reduction of thromboxane B2 level by 86%
Chlorella powder
-
the potent inhibition of cyclooxygenase-2 and thromboxane synthase contribute to the purported anti-inflmammatory and anti-thrombotic effect of Chlorella. This might be exploited for the prevention or treatment of several serious pathologies, including inflammatory diseases, immune and cancer
-
clotrimazole
-
as a heme ligand, molecular dynamics simulations of clotrimazole and 2-p-toluidinylnaphthalene-6-sulfonic acid-docking enzyme
Cu2+
-
1 mM, complete inhibition
CV4151
-
0.0000049 mM, 50% inhibition
-
indomethacin
-
0.000017 mM, 50% inhibition of PGE2 formation, 0.000013 mM, 50% inhibition of 12-HHT formation
linoleic acid
-
significant inhibition of cyclooxygenase/thromboxane synthase activity, determined by TXB2 production with an ELISA-based assay
linolelaidic acid
-
significant inhibition of cyclooxygenase/thromboxane synthase activity, determined by TXB2 production with an ELISA-based assay
N-isopropyl-N'-[(2-(3'-methylphenylamino)-5-nitrobenzene)sulfonyl]urea
-
-
N-isopropyl-N'-[2-(3'-methylphenylamino)-5-nitrobenzenesulfonyl]urea
-
0.001 mM, 95% inhibition
N-pentyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea
-
-
N-Substituted 3-(1H-imidazol-1-ylmethyl)indole carboxylic acid derivatives
-
-
-
N-tert-butyl-N'-(2-cyclohexylamino-5-nitrobenzenesulfonyl)urea
-
-
N-tert-butyl-N'-[(2-(4'-methylphenylamino)-5-nitrobenzene)sulfonyl]urea
-
-
N-tert-butyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea
-
-
NO
-
irreversible in a concentration-dependent manner
paclitaxel
-
45% inhibition at 0.1 mM
piperine
-
significant inhibition at 0.3 mM
prostaglandin H2
-
suicide inactivation
R68070
-
0.0000015 mM, 50% inhibition
radical scavenging glycoprotein
-
-
ridogrel
-
0.000004 mM, 50% inhibition
samixogrel
-
0.000004 mM, 50% inhibition
Sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate
-
immobilized enzyme
Sodium 5-(3'pyridinylmethyl)benzofuran-2-carboxylate
-
-
Sodium p-benzyl-4-[1-oxo-2-(4-chlorobenzyl)-3-phenyl propyl]phenyl phosphonate
-
-
thromboxane A2
-
the production of thromboxane A2 by the enzyme is self-limiting, the enzyme is inactivated during the reaction
Zn2+
-
1 mM, 50% inhibition
[3-[[Hydroxy[4-[3-methyl-2-(3-pyridinyl)indol-1-yl]butyl]phosphinyl]oxy]2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-1-yl]acetic acid
-
-
[4-[3-Methyl-2-(3-pyridinyl)-1H-indol-1-yl]butyl]phosphonic acid
-
-
[4-[3-Methyl-2-(3-pyridinyl)-1H-indol-1-yl]butyl]phosphonic acid monoethyl ester
-
-
1-Benzylimidazole
-
-
1-Benzylimidazole
-
immobilized enzyme
1-Benzylimidazole
-
special inhibitor of TXS
2-Isopropyl-3-nicotinylindole
-
-
2-Isopropyl-3-nicotinylindole
-
potent
4-{2-[(4-chlorophenyl)methyl]-3-phenylpropanoyl}phenyl hydrogen benzylphosphonate
-
i.e. N-0164
4-{2-[(4-chlorophenyl)methyl]-3-phenylpropanoyl}phenyl hydrogen benzylphosphonate
-
-
9alpha,11alpha-Methanoepoxy-15(S)-hydroxyprosta-5(cis)-13(trans)-dienoic acid
-
-
9alpha,11alpha-Methanoepoxy-15(S)-hydroxyprosta-5(cis)-13(trans)-dienoic acid
-
no inhibition
9alpha,11alpha-Methanoepoxy-15(S)-hydroxyprosta-5(cis)-13(trans)-dienoic acid
-
weak
dazoxiben
-
-
dazoxiben
-
competitive inhibitor
furegrelate
-
0.01 mM, 68% inhibition
furegrelate
-
cultures treated with show a reduced time-dependent increase in cell number compared with vehicle-treated cells. Addition to the growth medium results in reduction in cell invasion and reduction in cell migration.
furegrelate
-
specific inhibitor of thromboxane synthase, i.e. sodium 5-(3-pyridinylmethyl) benzofuran-2-carboxylate
furegrelate
-
specific inhibitor of TXSA
furegrelate
-
inhibition of thromboxane-A synthase, induces a concentration-dependent increase in cAMP-induced steroidogenic acute regulatory protein StAR concomitantly with a significant increase in steroid hormone production
imidazole
-
and derivatives. The potency of 1-substituted imidazoles is increased as the side chain becomes more hydrophobic. Inhibition is competitive with respect to prostaglandin endoperoxide substrate
ozagrel
-
cultures treated with show a reduced time-dependent increase in cell number compared with vehicle-treated cells. Addition to the growth medium results in reduction in cell invasion and reduction in cell migration.
ozagrel
-
competitive inhibitor
additional information
-
overview
-
additional information
-
the enzyme is insensitive to sulfhydryl reagents and thiols
-
additional information
-
the enzyme is not affected by nonsteroidal antiinflammatory agents
-
additional information
-
development of a screening assay for the in vitro evaluation of thromboxane A2 synthase inhibitors. Inhibitors of thromboxane synthase are regarded as potentially useful agents in the treatment of cardiovascular diseases and in the prevention of tumor cell metastases
-
additional information
-
dual angiotensin converting enzyme/thromboxane synthase inhibitors
-
additional information
-
design of new potential dual blocker which inhibits thromboxane synthase and antagonizes thromboxane A2 receptor
-
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Hecker, M.; Haurand, M.; Ullrich, V.; Diczfalusy, U.; Hammarstrm, S.
Products, kinetics, and substrate specificity of homogeneous thromboxane synthase from human platelets: development of a novel enzyme assay
Arch. Biochem. Biophys.
254
124-135
1987
Homo sapiens
brenda
Shen, R.F.; Tai, H.H.
Monoclonal antibodies to thromboxane synthase from porcine lung. Production and application to development of a tandem immunoradiometric assay
J. Biol. Chem.
261
11585-11591
1986
Sus scrofa
brenda
Shen, R.F.; Tai, H.H.
Immunoaffinity purification and characterization of thromboxane synthase from porcine lung
J. Biol. Chem.
261
11592-11599
1986
Sus scrofa
brenda
Hall, E.R.; Tuan, W.; Venton, D.L.
Production of platelet thromboxane A2 inactivates purified human platelet thromboxane synthase
Biochem. J.
233
637-641
1986
Homo sapiens
brenda
Haurand, M.; Ullrich, V.
Isolation and characterization of thromboxane synthase from human platelets as a cytochrome P-450 enzyme
J. Biol. Chem.
260
15059-15067
1985
Homo sapiens
brenda
Hecker, M.; Baader, W.J.; Weber, P.; Ullrich, V.
Thromboxane synthase catalyses hydroxylations of prostaglandin H2 analogs in the presence of iodosylbenzene
Eur. J. Biochem.
169
563-569
1987
Homo sapiens
brenda
Gorman, R.R.
Biology and biochemistry of thromboxane synthetase inhibitors
Adv. Prostaglandin Thromboxane Leukot. Res.
11
235-240
1983
Homo sapiens
brenda
Ullrich, V.; Haurand, M.
Thromboxane synthase as a cytochrome P450 enzyme
Adv. Prostaglandin Thromboxane Leukot. Res.
11
105-110
1983
Homo sapiens
brenda
Yashimoto, T.; Yamamoto, S.
Partial purification and assay of thromboxane A synthase from bovine platelets
Methods Enzymol.
86
106-109
1982
Bos taurus
brenda
Hall, E.R.; Tai, H.H.
Purification of thromboxane synthetase and evidence of two distinct mechanisms for the formation of 12-L-hydroxy-5,8,10-heptadecatrienoic acid by porcine lung microsomes
Biochim. Biophys. Acta
665
498-503
1981
Sus scrofa
brenda
Hammarstroem, S.
Enzymatic synthesis of 15-hydroperoxythromboxane A2 and 12-hydroperoxy-5,8,10-heptadecatrienoic acid
J. Biol. Chem.
255
518-521
1980
Homo sapiens
brenda
Hammarstroem, S.; Diczfalusy, U.
Inhibition and properties of thromboxane synthetase
Adv. Inflamm. Res.
1
431-438
1979
Homo sapiens
-
brenda
Wlodawer, P.; Hammarstroem, S.
Thromboxane synthase from bovine lung - solubilization and partial purification
Biochem. Biophys. Res. Commun.
80
525-532
1978
Bos taurus
brenda
Tai, H.H.; Yuan, B.
On the inhibitory potency of imidazole and its derivatives on thromboxane synthetase
Biochem. Biophys. Res. Commun.
80
236-242
1978
Homo sapiens
brenda
Diczfalusy, U.; Falardeau, P.; Hammarstrm, S.
Conversion of prostaglandin endoperoxides to C17-hydroxy acids catalyzed by human platelet thromboxane synthase
FEBS Lett.
84
271-274
1977
Homo sapiens
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Homo sapiens
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Oryctolagus cuniculus
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Homo sapiens
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Homo sapiens
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Homo sapiens
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Homo sapiens
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Homo sapiens
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Homo sapiens
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Homo sapiens
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Homo sapiens
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Homo sapiens
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Homo sapiens
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Homo sapiens
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Homo sapiens
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Homo sapiens
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Homo sapiens
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Canis lupus familiaris
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Mus musculus
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Homo sapiens
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Homo sapiens
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Chlorella powder inhibits the activities of peptidase cathepsin S, PLA2, cyclooxygenase-2, thromboxane synthase, tyrosine phosphatases, tumor necrosis factor-alpha converting enzyme, calpain and kinases
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Homo sapiens
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Oryctolagus cuniculus
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Homo sapiens
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Expression of thromboxane synthase, prostacyclin synthase and thromboxane receptor in atherosclerotic lesions: correlation with plaque composition
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Mus musculus
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Homo sapiens
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Park, S.A.; Park, B.L.; Park, J.H.; Lee, T.K.; Sung, K.B.; Lee, Y.K.; Chang, H.S.; Park, C.S.; Shin, H.D.
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Homo sapiens
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Leung, K.C.; Hsin, M.K.; Chan, J.S.; Yip, J.H.; Li, M.; Leung, B.C.; Mok, T.S.; Warner, T.D.; Underwood, M.J.; Chen, G.G.
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Homo sapiens
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Wright, W.S.; McElhatten, R.M.; Harris, N.R.
Expression of thromboxane synthase and the thromboxane-prostanoid receptor in the mouse and rat retina
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Mus musculus, Rattus norvegicus
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Gabrielsen, A.; Qiu, H.; Baeck, M.; Hamberg, M.; Hemdahl, A.L.; Agardh, H.; Folkersen, L.; Swedenborg, J.; Hedin, U.; Paulsson-Berne, G.; Haeggstroem, J.Z.; Hansson, G.K.
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Homo sapiens, Mus musculus
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Schauff, A.; Kim, E.; Leppert, J.; Nadrowitz, R.; Wuestenberg, R.; Brockmann, M.; Giese, A.
Inhibition of invasion-associated thromboxane synthase sensitizes experimental gliomas to gamma-radiation
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Homo sapiens
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Schmidt, N.O.; Ziu, M.; Cargioli, T.; Westphal, M.; Giese, A.; Black, P.M.; Carroll, R.S.
Inhibition of thromboxane synthase activity improves glioblastoma response to alkylation chemotherapy
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Homo sapiens
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Muzaffar, S.; Shukla, N.; Massey, Y.; Angelini, G.D.; Jeremy, J.Y.
NADPH oxidase 1 mediates upregulation of thromboxane A2 synthase in human vascular smooth muscle cells: inhibition with iloprost
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Homo sapiens
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Chao, W.C.; Lu, J.F.; Wang, J.S.; Yang, H.C.; Pan, T.A.; Chou, S.C.; Wang, L.H.; Chou, P.T.
Probing ligand binding to thromboxane synthase
Biochemistry
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2013
Homo sapiens
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Das, A.; Varma, S.S.; Mularczyk, C.; Meling, D.D.
Functional investigations of thromboxane synthase (CYP5A1) in lipid bilayers of nanodiscs
ChemBioChem
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Homo sapiens
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Cathcart, M.C.; Gately, K.; Cummins, R.; Kay, E.; OByrne, K.J.; Pidgeon, G.P.
Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer
Mol. Cancer
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Homo sapiens
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Sathler, P.; Santana, M.; Loureno, A.; Rodrigues, C.; Abreu, P.; Cabral, L.; Castro, H.
Human thromboxane synthase Comparative modeling and docking evaluation with the competitive inhibitors dazoxiben and ozagrel
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Homo sapiens
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Son, D.J.; Akiba, S.; Hong, J.T.; Yun, Y.P.; Hwang, S.Y.; Park, Y.H.; Lee, S.E.
Piperine inhibits the activities of platelet cytosolic phospholipase A2 and thromboxane A2 synthase without affecting cyclooxygenase-1 activity different mechanisms of action are involved in the inhibition of platelet aggregation and macrophage inflammatory response
Nutrients
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2014
Oryctolagus cuniculus
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