5.3.99.5: thromboxane-A synthase
This is an abbreviated version!
For detailed information about thromboxane-A synthase, go to the full flat file.
Word Map on EC 5.3.99.5
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5.3.99.5
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platelet
-
prostaglandin
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arachidonic
-
artery
-
cyclooxygenase
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prostacyclin
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indomethacin
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endothelial
-
endoperoxide
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pulmonary
-
prostanoids
-
aspirin
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dazoxiben
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coronary
-
eicosanoids
-
vasoconstrictor
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leukotriene
-
imidazole
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hypertension
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thrombosis
-
aorta
-
hemodynamic
-
antiplatelet
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6-keto-pgf1
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cox-2
-
5-lipoxygenase
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6-keto-prostaglandin
-
vasodilator
-
antithrombotic
-
ozagrel
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endothelium-dependent
-
thrombus
-
paf
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endothelium-derived
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bronchoconstriction
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6-keto
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platelet-rich
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constrictor
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collagen-induced
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aa-induced
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analysis
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medicine
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aspirin-treated
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pharmacology
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ticlopidine
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reocclusion
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meclofenamate
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f1alpha
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pgg2
-
iloprost
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antiaggregatory
-
14c-arachidonic
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proaggregatory
- 5.3.99.5
- platelet
- prostaglandin
-
arachidonic
- artery
-
cyclooxygenase
- prostacyclin
- indomethacin
- endothelial
-
endoperoxide
- pulmonary
-
prostanoids
- aspirin
- dazoxiben
- coronary
-
eicosanoids
-
vasoconstrictor
-
leukotriene
- imidazole
- hypertension
- thrombosis
- aorta
-
hemodynamic
-
antiplatelet
-
6-keto-pgf1
- cox-2
-
5-lipoxygenase
-
6-keto-prostaglandin
-
vasodilator
-
antithrombotic
- ozagrel
-
endothelium-dependent
- thrombus
- paf
-
endothelium-derived
-
bronchoconstriction
-
6-keto
-
platelet-rich
-
constrictor
-
collagen-induced
-
aa-induced
- analysis
- medicine
-
aspirin-treated
- pharmacology
- ticlopidine
-
reocclusion
- meclofenamate
-
f1alpha
- pgg2
-
iloprost
-
antiaggregatory
-
14c-arachidonic
-
proaggregatory
Reaction
Synonyms
CYP5A1, Synthetase, thromboxane, TBXAS1, Thromboxan synthetase, thromboxane A synthase 1, thromboxane A-synthase, thromboxane A2 synthase, thromboxane A2 synthase 1, Thromboxane A2 synthetase, thromboxane synthase, Thromboxane synthetase, TXA synthase, TxA-synthase, TXA2 synthase, TXAS, TXS, TXSA, TxSI
ECTree
5.3.99.5 thromboxane-A synthaseAdvanced search results
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results (Engineering
Engineering on EC 5.3.99.5 - thromboxane-A synthase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
L488P
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in alpha-helix, indroducing a coil in the secondary structure, crucial for enzyme activity
L83P
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in beta-sheet, indroducing a coil in the secondary structure, crucial for enzyme activity
Q482W
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changing an aliphatic amino acid with low steric hindrance into an aromatic amino acid with high steric hindrance in the vicinitx of the catalytic site, modifying the interaction of the enzyme-substarte complex, crucial for enzyme activity
W133F
W203F
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site-directed mutagenesis, ligand binding analysis compared to the wild-type enzyme
W31F
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site-directed mutagenesis, ligand binding analysis compared to the wild-type enzyme
W31F/W65F/W133F/W203F/W466F
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site-directed mutagenesis, ligand binding analysis compared to the wild-type enzyme
W466F
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site-directed mutagenesis, ligand binding analysis compared to the wild-type enzyme
W65F
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site-directed mutagenesis, ligand binding analysis compared to the wild-type enzyme
additional information
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treatment with enzyme-specific RNAi results in increased levels of steroidogenic acute regulatory protein StAR and steroidogenesis. Inhibition of enzyme activity reduces the levels of StaR transcriptional repressor DAX-1
W133F
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site-directed mutagenesis, ligand binding analysis compared to the wild-type enzyme
