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Literature summary for 5.3.99.5 extracted from

  • Hsu, P.Y.; Tsai, A.L.; Wang, L.H.
    Identification of thromboxane synthase amino acid residues involved in heme-propionate binding (2000), Arch. Biochem. Biophys., 383, 119-127.
    View publication on PubMed
Search for more literature for 5.3.99.5

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
A408L 42% of wild-type activity Homo sapiens
A415V 82% of wild-type activity Homo sapiens
C480H no activity Homo sapiens
C480S no activity Homo sapiens
C480Y no activity Homo sapiens
E134D 35% of wild-type activity Homo sapiens
E135D 123% of wild-type activity Homo sapiens
E414D 39% of wild-type activity Homo sapiens
F409Y 42% of wild-type activity Homo sapiens
F411Y 38% of wild-type activity Homo sapiens
N110I no activity Homo sapiens
R137A 2% of wild-type activity Homo sapiens
R137K 5% of wild-type activity Homo sapiens
R410G 46% of wild-type activity Homo sapiens
R413K 1% of wild-type activity Homo sapiens
R478A no activity Homo sapiens
T412S 41% of wild-type activity Homo sapiens
V136A 69% of wild-type activity Homo sapiens
W133F 2% of wild-type activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Homo sapiens
-
 (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate i.e. TXA2 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant TXAS Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
 Homo sapiens (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate i.e. TXA2 ?

Synonyms

Synonyms Comment Organism
TXAS
-
 Homo sapiens