4.4.1.21: S-ribosylhomocysteine lyase
This is an abbreviated version!
For detailed information about S-ribosylhomocysteine lyase, go to the full flat file.
Word Map on EC 4.4.1.21
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4.4.1.21
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quorum
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quorum-sensing
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interspecies
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harveyi
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thioether
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4,5-dihydroxy-2,3-pentanedione
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nucleosidase
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luxs-dependent
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furanone
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medicine
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analysis
- 4.4.1.21
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quorum
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quorum-sensing
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interspecies
- harveyi
- thioether
- 4,5-dihydroxy-2,3-pentanedione
- nucleosidase
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luxs-dependent
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furanone
- medicine
- analysis
Reaction
Synonyms
AI-2 synthase, autoinducer-2 synthase, BsLuxS, EC 3.13.1.2, EC 3.2.1.148, EC 3.3.1.3, EcLuxS, lsrR, Lux S, LuxS, LuxS protein, S-ribosyl homocysteinase, S-ribosylhomocysteinase, S-ribosylhomocysteine lyase, S-ribosylhomocysteinelyase, VhLuxS
ECTree
4.4.1.21 S-ribosylhomocysteine lyaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 4.4.1.21 - S-ribosylhomocysteine lyase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine
L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione
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?
S-ribosylhomocysteine
homocysteine + 4,5-dihydroxy-2,3-pentanedione
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the autoinducer Al-2, a five-carbon furanone results from the spontaneous cyclization of 4,5-dihydroxy-2,3-pentanedione
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?
S-ribosylhomocysteine
homocysteine + 4,5-dihydroxy-2,3-pentanedione
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the autoinducer Al-2, a five-carbon furanone results from the spontaneous cyclization of 4,5-dihydroxy-2,3-pentanedione
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?
S-ribosylhomocysteine
L-homocysteine + 4,5-dihydroxy-2,3-pentanedione
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key step in biosynthesis pathway of type II autoinducer AI-2
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?
S-ribosylhomocysteine
L-homocysteine + 4,5-dihydroxy-2,3-pentanedione
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enzyme is involved in synthesis of the autoinducer AI-2 that is an universal signal, which may be used by a variety of bacteria for communication among and between species and may be responsible for regulation of virulence genes in Escherichia coli O157:H7
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?
S-ribosylhomocysteine
L-homocysteine + 4,5-dihydroxy-2,3-pentanedione
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the enzyme is required for AI-2 synthesis, important metabolic function in recycling of S-adenosylhomocysteine
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?
S-ribosylhomocysteine
L-homocysteine + 4,5-dihydroxy-2,3-pentanedione
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the enzyme is required for AI-2 synthesis, important metabolic function in recycling of S-adenosylhomocysteine
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?
S-ribosylhomocysteine
L-homocysteine + 4,5-dihydroxy-2,3-pentanedione
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the enzyme is required for AI-2 synthesis, important metabolic function in recycling of S-adenosylhomocysteine
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?
S-ribosylhomocysteine
L-homocysteine + 4,5-dihydroxy-2,3-pentanedione
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the enzyme is required for AI-2 synthesis, important metabolic function in recycling of S-adenosylhomocysteine
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?
additional information
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LuxS is functional in the autoinducer-2-mediated quorum sensing and may regulate different behaviors including biofilm formation and virulence
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additional information
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LuxS is functional in the autoinducer-2-mediated quorum sensing and may regulate different behaviors including biofilm formation and virulence
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additional information
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autoinducer 2 synthesis enzyme assay using Vibrio harveyi sensor strains, wild-type BB120 is a sensor mutant derived from BB120 and responds only to presence of AI-2, but not the other autoinducers from Vibrio harveyi
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?
additional information
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autoinducer 2 synthesis enzyme assay using Vibrio harveyi sensor strains, wild-type BB120 is a sensor mutant derived from BB120 and responds only to presence of AI-2, but not the other autoinducers from Vibrio harveyi
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?
additional information
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LuxS catalyzes production of the AI-2 autoinducer molecule for a second quorum sensing system
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?
additional information
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LuxS catalyzes the last step in the production of autoinducer-2
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additional information
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LuxS catalyzes the last step in the production of autoinducer-2
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?
additional information
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LuxS catalyzes production of the AI-2 autoinducer molecule for a second quorum sensing system
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?
additional information
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LuxS catalyzes production of the AI-2 autoinducer molecule for a second quorum sensing system
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?
additional information
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LuxS is required for normal biofilm development
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additional information
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LuxS is required for normal biofilm development
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additional information
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growth phase regulation of flaA expression in Helicobacter pylori is luxS-dependent
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additional information
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LuxS is required for normal biofilm development
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?
additional information
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LuxS is involved in the activated methyl cycle and influences biofilm formation
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additional information
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Shewanella oneidensis MR-1 / ATCC 700550
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LuxS is involved in the activated methyl cycle and influences biofilm formation
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additional information
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the LuxS/AI-2 (autoinducer 2) system does not appear to contribute to the overall fitness of Staphylococcus aureus RN6390B during intracellular growth in epithelial cells
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additional information
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LuxS is required for normal biofilm development
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additional information
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the LuxS/AI-2 (autoinducer 2) system does not appear to contribute to the overall fitness of Staphylococcus aureus RN6390B during intracellular growth in epithelial cells
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additional information
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LuxS is related on the one hand to down-regulation of competence, and on the other hand to attenuation of autolysis in cultures entering stationary phase. The impact of LuxS on competence, but not on autolysis, involves cel-cell communication
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additional information
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LuxS plays an important role in the regulation of motility and flagella biogenesis
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additional information
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the LuxS quorum sensing system plays an important role in regulating the expression of virulence factors
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additional information
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LuxS plays an important role in the regulation of motility and flagella biogenesis
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additional information
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LuxS catalyzes production of the AI-2 autoinducer molecule for a second quorum sensing system
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?
additional information
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the enzyme is involved in one of the the quorum sensing systems that function in parallel to control the density-dependent expression of the luciferase structural operon luxCDABE. Each system is composed of a sensor, sensor I or sensor 2, and its cognate autoinducer, AI-1 or AI-2. LuxS has a role in the enzymatic synthesis of AI-2
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