4.4.1.21: S-ribosylhomocysteine lyase

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For detailed information about S-ribosylhomocysteine lyase, go to the full flat file.

Word Map on EC 4.4.1.21

4.4.1.21

quorum

quorum-sensing

interspecies

harveyi

thioether

4,5-dihydroxy-2,3-pentanedione

nucleosidase

luxs-dependent

furanone

medicine

analysis

Reaction

Synonyms

AI-2 synthase, autoinducer-2 synthase, BsLuxS, EC 3.13.1.2, EC 3.2.1.148, EC 3.3.1.3, EcLuxS, lsrR, Lux S, LuxS, LuxS protein, S-ribosyl homocysteinase, S-ribosylhomocysteinase, S-ribosylhomocysteine lyase, S-ribosylhomocysteinelyase, VhLuxS

ECTree

4 Lyases

4.4 Carbon-sulfur lyases

4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)

4.4.1.21 S-ribosylhomocysteine lyase

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Results	in table
2	Activating Compound
10500	AA Sequence
2	Application
1	CAS Registry Number
21	Cloned(Commentary)
7	Crystallization (Commentary)
1	Expression
34	General Information
2	General Stability
35	Inhibitors
5	kcat/KM [mM/s]
32	Ki Value [mM]
32	KM Value [mM]
35	Metals/Ions
1	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
183	Organism
1	Oxidation Stability
8	Pathway
11	PDB ID
1	pH Optimum
2	pI Value
46	Protein Variants
9	Purification (Commentary)
3	Reaction
13	Reaction Type
160	Reference
2	Source Tissue
1	Storage Stability
135	Substrates and Products (Substrate)
7	Subunits
188	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Stability [°C]
23	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.4.1.21 - S-ribosylhomocysteine lyase

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S-(5-deoxy-D-ribos-5-yl)-L-homocysteine L-homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming]

Contains Fe2+. The 4,5-dihydroxypentan-2,3-dione formed spontaneously cyclizes and combines with borate to form an autoinducer (AI-2) in the bacterial quorum-sensing mechanism, which is used by many bacteria to control gene expression in response to cell density [2].