Reference on EC 4.4.1.21 - S-ribosylhomocysteine lyase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Das, S.K.; Sedelnikova, S.E.; Baker, P.J.; Ruzheinikov, S.N.; Foster, S.; Hartley, A.; Horsburgh, M.J.; Rice, D.W.
Cloning, purification, crystallization and preliminary crystallographic analysis of Bacillus subtilis LuxS
Acta Crystallogr. Sect. D
57
1324-1325
2001
Bacillus subtilis
Miller, M.B.; Bassler, B.L.B.
Quorum sensing in bacteria
Annu. Rev. Microbiol.
55
165-199
2001
Vibrio harveyi
Zhu, J.; Dizin, E.; Hu, X.; Wavreille, A.S.; Park, J.; Pei, D.
S-Ribosylhomocysteinase (LuxS) is a mononuclear iron protein
Biochemistry
42
4717-4726
2003
Bacillus subtilis
Anand, S.K.; Griffiths, M.W.
Quorum sensing and expression of virulence in Escherichia coli O157:H7
Int. J. Food Microbiol.
85
1-9
2003
Escherichia coli
Ruzheinikov, S.N.; Das, S.K.; Sedelnikova, S.E.; Hartley, A.; Foster, S.J.; Horsburgh, M.J.; Cox, A.G.; McCleod, C.W.; Mekhalfia, A.; Blackburn, G.M.; Rice, D.W.; Baker, P.J.
The 1.2 A structure of a novel quorum-sensing protein, Bacillus subtilis LuxS
J. Mol. Biol.
313
111-122
2001
Bacillus subtilis (O34667)
Winzer, K.; Hardie, K.R.; Burgess, N.; Doherty, N.; Kirke, D.; Holden, M.T.; Linforth, R.; Cornell, K.A.; Taylor, A.J.; Hill, P.J.; Williams, P.
LuxS: its role in central metabolism and the in vitro synthesis of 4-hydroxy-5-methyl-3(2H)-furanone
Microbiology
148
909-922
2002
Porphyromonas gingivalis, Escherichia coli, Staphylococcus aureus, Neisseria meningitidis, no activity in Pseudomonas aeruginosa
Schauder, S.; Shokat, K.; Surette, M.G.; Bassler, B.L.
The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule
Mol. Microbiol.
41
463-476
2001
Vibrio harveyi, Vibrio harveyi BB170
Hilgers, M.T.; Ludwig, M.L.
Crystal structure of the quorum-sensing protein LuxS reveals a catalytic metal site
Proc. Natl. Acad. Sci. USA
98
11169-11174
2001
Bacillus subtilis (O34667)
Zhu, J.; Patel, R.; Pei, D.
Catalytic mechanism of S-ribosylhomocysteinase (LuxS): stereochemical course and kinetic isotope effect of proton transfer reactions
Biochemistry
43
10166-10172
2004
Bacillus subtilis, Vibrio harveyi
Rajan, R.; Zhu, J.; Hu, X.; Pei, D.; Bell, C.E.
Crystal structure of S-ribosylhomocysteinase (LuxS) in complex with a catalytic 2-ketone intermediate
Biochemistry
44
3745-3753
2005
Vibrio harveyi, Bacillus subtilis (O34667), Bacillus subtilis
Loh, J.T.; Forsyth, M.H.; Cover, T.L.
Growth phase regulation of flaA expression in Helicobacter pylori is luxS dependent
Infect. Immun.
72
5506-5510
2004
Helicobacter pylori
Lupp, C.; Ruby, E.G.
Vibrio fischeri LuxS and AinS: comparative study of two signal synthases
J. Bacteriol.
186
3873-3881
2004
Aliivibrio fischeri
Doherty, N.; Holden, M.T.; Qazi, S.N.; Williams, P.; Winzer, K.
Functional analysis of luxS in Staphylococcus aureus reveals a role in metabolism but not quorum sensing
J. Bacteriol.
188
2885-2897
2006
Staphylococcus aureus, Staphylococcus aureus RN6390B
Romao, S.; Memmi, G.; Oggioni, M.R.; Trombe, M.C.
LuxS impacts on LytA-dependent autolysis and on competence in Streptococcus pneumoniae
Microbiology
152
333-341
2006
Streptococcus pneumoniae
Hullo, M.F.; Auger, S.; Soutourina, O.; Barzu, O.; Yvon, M.; Danchin, A.; Martin-Verstraete, I.
Conversion of methionine to cysteine in Bacillus subtilis and its regulation
J. Bacteriol.
189
187-197
2007
Bacillus subtilis (O34667), Bacillus subtilis 168 (O34667)
Zhu, J.; Knottenbelt, S.; Kirk, M.L.; Pei, D.
Catalytic mechanism of S-ribosylhomocysteinase: ionization state of active-site residues
Biochemistry
45
12195-12203
2006
Bacillus subtilis (O34667), Escherichia coli (P45578), Escherichia coli, Vibrio harveyi (Q9Z5X1)
Walters, M.; Sircili, M.P.; Sperandio, V.
AI-3 synthesis is not dependent on luxS in Escherichia coli
J. Bacteriol.
188
5668-5681
2006
Escherichia coli (Q8X902)
Shen, G.; Rajan, R.; Zhu, J.; Bell, C.E.; Pei, D.
Design and synthesis of substrate and intermediate analogue inhibitors of S-ribosylhomocysteinase
J. Med. Chem.
49
3003-3011
2006
Escherichia coli (P45578)
Wnuk, S.F.; Lalama, J.; Robert, J.; Garmendia, C.A.
Novel S-ribosylhomocysteine analogues as potential inhibitors of LuxS enzyme
Nucleosides Nucleotides Nucleic Acids
26
1051-1055
2007
Bacillus subtilis (O34667)
Jelcic, I.; Huefner, E.; Schmidt, H.; Hertel, C.
Repression of the locus of the enterocyte effacement-encoded regulator of gene transcription of Escherichia coli O157:H7 by Lactobacillus reuteri culture supernatants is LuxS and strain dependent
Appl. Environ. Microbiol.
74
3310-3314
2008
Limosilactobacillus reuteri (Q2F7Q0)
Lebeer, S.; Claes, I.J.; Verhoeven, T.L.; Shen, C.; Lambrichts, I.; Ceuppens, J.L.; Vanderleyden, J.; De Keersmaecker, S.C.
Impact of luxS and suppressor mutations on the gastrointestinal transit of Lactobacillus rhamnosus GG
Appl. Environ. Microbiol.
74
4711-4718
2008
Lacticaseibacillus rhamnosus, Lacticaseibacillus rhamnosus GG
Learman, D.R.; Yi, H.; Brown, S.D.; Martin, S.L.; Geesey, G.G.; Stevens, A.M.; Hochella, M.F.
Shewanella oneidensis MR-1 LuxS involvement in biofilm development and sulfur metabolism
Appl. Environ. Microbiol.
75
1301-1307
2009
Shewanella oneidensis, Shewanella oneidensis MR-1 / ATCC 700550
Tian, Y.; Wang, Q.; Liu, Q.; Ma, Y.; Cao, X.; Guan, L.; Zhang, Y.
Involvement of LuxS in the regulation of motility and flagella biogenesis in Vibrio alginolyticus
Biosci. Biotechnol. Biochem.
72
1063-1071
2008
Vibrio alginolyticus, Vibrio alginolyticus MVP01
Bodor, A.; Elxnat, B.; Thiel, V.; Schulz, S.; Wagner-Doebler, I.
Potential for luxS related signalling in marine bacteria and production of autoinducer-2 in the genus Shewanella
BMC Microbiol.
8
13
2008
Shewanella oneidensis, Vibrio harveyi, Shewanella algae, Shewanella frigidimarina, no activity in Alphaproteobacteria, no activity in Bacteroidetes, Alishewanella fetalis, Shewanella fidelis, Shewanella japonica, Shewanella marinintestina, Shewanella sairae, Shewanella schlegeliana, Shewanella hafniensis, Shewanella frigidimarina LMG 18921T, Shewanella sairae LMG 21408T, Shewanella fidelis LMG 20552T, Shewanella marinintestina LMG 21403T, Shewanella japonica LMG 19691T, Alishewanella fetalis CCUG 30811T, Shewanella schlegeliana LMG 21406T, Shewanella hafniensis DT-1, Shewanella oneidensis MR-1 / ATCC 700550
Rezzonico, F.; Duffy, B.
Lack of genomic evidence of AI-2 receptors suggests a non-quorum sensing role for luxS in most bacteria
BMC Microbiol.
8
154
2008
Bifidobacterium adolescentis, no activity in Sinorhizobium meliloti, no activity in Rhodobacter sphaeroides strain 2.4.1, no activity in Marinomonas sp., no activity in Neptuniibacter caesariensis, no activity in Desulfovibrio desulfuricans, no activity in Rhodobacter capsulatus, Erwinia billingiae (Q003Y1), Vibrio anguillarum (Q1KMU6), Erwinia tasmaniensis (Q2PA28), no activity in Marinomonas sp. MED121
Siller, M.; Janapatla, R.P.; Pirzada, Z.A.; Hassler, C.; Zinkl, D.; Charpentier, E.
Functional analysis of the group A streptococcal luxS/AI-2 system in metabolism, adaptation to stress and interaction with host cells
BMC Microbiol.
8
188
2008
Streptococcus pyogenes
Tavender, T.J.; Halliday, N.M.; Hardie, K.R.; Winzer, K.
LuxS-independent formation of AI-2 from ribulose-5-phosphate
BMC Microbiol.
8
98
2008
Vibrio harveyi
Zhu, H.; Sun, S.J.; Dang, H.Y.
PCR detection of Serratia spp. using primers targeting pfs and luxS genes involved in AI-2-dependent quorum sensing
Curr. Microbiol.
57
326-330
2008
no activity in Agrobacterium tumefaciens, no activity in Enterobacter aerogenes, no activity in Escherichia coli, no activity in Klebsiella pneumoniae, no activity in Salmonella typhimurium, no activity in Vibrio vulnificus, no activity in Zymomonas mobilis, Serratia ficaria, Serratia fonticola, Serratia kiliensis, Serratia liquefaciens, Serratia malilotii, Serratia marcescens (A1Z1R8), Serratia odorifera, Serratia plymuthica, Serratia proteamaculans, Serratia putrefaciens
Gao, Y.; Song, J.; Hu, B.; Zhang, L.; Liu, Q.; Liu, F.
The luxS gene is involved in AI-2 production, pathogenicity, and some phenotypes in Erwinia amylovora
Curr. Microbiol.
58
1-10
2009
Erwinia amylovora, Erwinia amylovora NCPPB1665 (Ea1665)
Han, X.G.; Lu, C.P.
Detection of autoinducer-2 and analysis of the profile of luxS and pfs transcription in Streptococcus suis serotype 2
Curr. Microbiol.
58
146-152
2009
Streptococcus suis
He, Y.; Frye, J.G.; Strobaugh, T.P.; Chen, C.Y.
Analysis of AI-2/LuxS-dependent transcription in Campylobacter jejuni strain 81-176
Foodborne Pathog. Dis.
5
399-415
2008
Campylobacter jejuni (Q3I354), Campylobacter jejuni 81-176 (Q3I354)
Gopishetty, B.; Zhu, J.; Rajan, R.; Sobczak, A.J.; Wnuk, S.F.; Bell, C.E.; Pei, D.
Probing the catalytic mechanism of S-ribosylhomocysteinase (LuxS) with catalytic intermediates and substrate analogues
J. Am. Chem. Soc.
131
1243-1250
2009
Bacillus subtilis, Escherichia coli, Vibrio harveyi
Heurlier, K.; Vendeville, A.; Halliday, N.; Green, A.; Winzer, K.; Tang, C.M.; Hardie, K.R.
Growth deficiencies of Neisseria meningitidis pfs and luxS mutants are not due to inactivation of quorum sensing
J. Bacteriol.
191
1293-1302
2009
Neisseria meningitidis
Ye, J.; Ma, Y.; Liu, Q.; Zhao, D.L.; Wang, Q.Y.; Zhang, Y.X.
Regulation of Vibrio alginolyticus virulence by the LuxS quorum-sensing system
J. Fish Dis.
31
161-169
2008
Vibrio alginolyticus (A6XJQ9)
Huang, Z.; Meric, G.; Liu, Z.; Ma, R.; Tang, Z.; Lejeune, P.
luxS-Based quorum-sensing signaling affects biofilm formation in Streptococcus mutans
J. Mol. Microbiol. Biotechnol.
17
12-19
2008
Streptococcus mutans
Li, L.; Zhou, R.; Li, T.; Kang, M.; Wan, Y.; Xu, Z.; Chen, H.
Enhanced biofilm formation and reduced virulence of Actinobacillus pleuropneumoniae luxS mutant
Microb. Pathog.
45
192-200
2008
Actinobacillus pleuropneumoniae, Actinobacillus pleuropneumoniae 4074
Kozlova, E.V.; Popov, V.L.; Sha, J.; Foltz, S.M.; Erova, T.E.; Agar, S.L.; Horneman, A.J.; Chopra, A.K.
Mutation in the S-ribosylhomocysteinase (luxS) gene involved in quorum sensing affects biofilm formation and virulence in a clinical isolate of Aeromonas hydrophila
Microb. Pathog.
45
343-354
2008
Aeromonas hydrophila (B1PWE7), Aeromonas hydrophila
Zhang, M.; Sun, K.; Sun, L.
Regulation of autoinducer 2 production and luxS expression in a pathogenic Edwardsiella tarda strain
Microbiology
154
2060-2069
2008
Edwardsiella tarda (B4XQ50), Edwardsiella tarda, Edwardsiella tarda TX1 (B4XQ50)
Hardie, K.R.; Heurlier, K.
Establishing bacterial communities by word of mouth: LuxS and autoinducer 2 in biofilm development
Nat. Rev. Microbiol.
6
635-643
2008
Bacillus subtilis, Campylobacter jejuni, Escherichia coli, Haemophilus influenzae, Helicobacter pylori, Staphylococcus aureus, Serratia plymuthica, Vibrio harveyi
Pecharki, D.; Petersen, F.C.; Scheie, A.A.
LuxS and expression of virulence factors in Streptococcus intermedius
Oral Microbiol. Immunol.
23
79-83
2008
Streptococcus intermedius
Wnuk, S.F.; Robert, J.; Sobczak, A.J.; Meyers, B.P.; Malladi, V.L.; Zhu, J.; Gopishetty, B.; Pei, D.
Inhibition of S-ribosylhomocysteinase (LuxS) by substrate analogues modified at the ribosyl C-3 position
Bioorg. Med. Chem.
17
6699-6706
2009
Bacillus subtilis (O34667)
Bhattacharyya, M.; Vishveshwara, S.
Functional correlation of bacterial LuxS with their quaternary associations: interface analysis of the structure networks
BMC Struct. Biol.
9
8
2009
Psychromonas ingrahamii (A1SZZ2), Bacillus subtilis (O34667), Streptococcus pyogenes (P0C0C7), Haemophilus influenzae (P44007), Clostridium perfringens (Q0SWJ6), Deinococcus geothermalis (Q1IW42), Lactobacillus acidophilus (Q5FK48), Limosilactobacillus reuteri (Q5QHW1), Alkalihalobacillus clausii (Q5WDW1), Staphylococcus aureus (Q6GEU1), Thermus thermophilus (Q72IE6), Lactobacillus johnsonii (Q74HV0), Bacillus cereus (Q816N5), Bacillus anthracis (Q81KF3), Shigella flexneri (Q83JZ4), Staphylococcus epidermidis (Q8CNI0), Streptococcus mutans (Q8DVK8), Bifidobacterium longum (Q8G568), Escherichia coli (Q8X902), Vibrio cholerae (Q9KUG4), Campylobacter jejuni (Q9PN97), Deinococcus radiodurans (Q9RRU8), Helicobacter pylori (Q9ZMW8)
Pereira, C.S.; McAuley, J.R.; Taga, M.E.; Xavier, K.B.; Miller, S.T.
Sinorhizobium meliloti, a bacterium lacking the autoinducer-2 (AI-2) synthase, responds to AI-2 supplied by other bacteria
Mol. Microbiol.
70
1223-1235
2008
no activity in Sinorhizobium meliloti
Halliday, N.M.; Hardie, K.R.; Williams, P.; Winzer, K.; Barrett, D.A.
Quantitative liquid chromatography-tandem mass spectrometry profiling of activated methyl cycle metabolites involved in LuxS-dependent quorum sensing in Escherichia coli
Anal. Biochem.
403
20-29
2010
Escherichia coli
Malladi, V.L.; Sobczak, A.J.; Meyer, T.M.; Pei, D.; Wnuk, S.F.
Inhibition of LuxS by S-ribosylhomocysteine analogues containing a [4-aza]ribose ring
Bioorg. Med. Chem.
19
5507-5519
2011
Bacillus subtilis
Trappetti, C.; Potter, A.J.; Paton, A.W.; Oggioni, M.R.; Paton, J.C.
LuxS mediates iron-dependent biofilm formation, competence and fratricide in Streptococcus pneumoniae
Infect. Immun.
79
4550-4558
2011
Streptococcus pneumoniae
Doherty, N.C.; Shen, F.; Halliday, N.M.; Barrett, D.A.; Hardie, K.R.; Winzer, K.; Atherton, J.C.
In Helicobacter pylori, LuxS is a key enzyme in cysteine provision through a reverse transsulfuration pathway
J. Bacteriol.
192
1184-1192
2010
Helicobacter pylori
Li, H.; Zhao, H.; Zhu, L.; Hong, L.; Zhang, H.; Lin, F.; Xu, C.; Li, S.; Zhang, Z.
Crystallization and preliminary X-ray analysis of S-ribosylhomocysteinase from Streptococcus mutans
Acta Crystallogr. Sect. F
68
199-202
2012
Streptococcus mutans
Wilson, C.M.; Aggio, R.B.; OToole, P.W.; Villas-Boas, S.; Tannock, G.W.
Transcriptional and metabolomic consequences of LuxS inactivation reveal a metabolic rather than quorum-sensing role for LuxS in Lactobacillus reuteri 100-23
J. Bacteriol.
194
1743-1746
2012
Limosilactobacillus reuteri (B3XKW0), Limosilactobacillus reuteri, Limosilactobacillus reuteri 100-23 (B3XKW0)
Peixoto, R.J.; Miranda, K.R.; Ferreira, E.O.; de Paula, G.R.; Rocha, E.R.; Lobo, L.A.; Domingues, R.M.
Production of AI-2 is mediated by the S-ribosylhomocystein lyase gene luxS in Bacteroides fragilis and Bacteroides vulgatus
J. Basic Microbiol.
54
644-649
2014
Bacteroides fragilis, Phocaeicola vulgatus (A6KYS6), Phocaeicola vulgatus, Bacteroides fragilis B3b, Phocaeicola vulgatus ATCC 8482 (A6KYS6), Phocaeicola vulgatus ATCC 8482
Cao, M.; Feng, Y.; Wang, C.; Zheng, F.; Li, M.; Liao, H.; Mao, Y.; Pan, X.; Wang, J.; Hu, D.; Hu, F.; Tang, J.
Functional definition of LuxS, an autoinducer-2 (AI-2) synthase and its role in full virulence of Streptococcus suis serotype 2
J. Microbiol.
49
1000-1011
2011
Streptococcus suis (A4VTE8), Streptococcus suis 05ZYH33 (A4VTE8)
Huang, W.; Gherib, R.; Gauld, J.W.
An active site water broadens substrate specificity in S-ribosylhomocysteinase (LuxS): a docking, MD, and QM/MM study
J. Phys. Chem. B
116
8916-8929
2012
Bacillus subtilis
He, Z.; Liang, J.; Zhou, W.; Xie, Q.; Tang, Z.; Ma, R.; Huang, Z.
Effect of the quorum-sensing luxS gene on biofilm formation by Enterococcus faecalis
Eur. J. Oral Sci.
124
234-240
2016
Enterococcus faecalis, Enterococcus faecalis ATCC 33186
Wang, Y.; Yi, L.; Wang, S.; Fan, H.; Ding, C.; Mao, X.; Lu, C.
Crystal structure and identification of two key amino acids involved in AI-2 production and biofilm formation in Streptococcus suis LuxS
PLoS ONE
10
e0138826
2015
Streptococcus suis (B2CMA5), Streptococcus suis
Song, X.D.; Liu, C.J.; Huang, S.H.; Li, X.R.; Yang, E.; Luo, Y.Y.
Cloning, expression and characterization of two S-ribosylhomocysteine lyases from Lactobacillus plantarum YM-4-3 Implication of conserved and divergent roles in quorum sensing
Protein Expr. Purif.
145
32-38
2018
Lactiplantibacillus plantarum (ETF12584), Lactiplantibacillus plantarum (ETF12641), Lactiplantibacillus plantarum, Lactiplantibacillus plantarum YM-4-3 (ETF12584), Lactiplantibacillus plantarum YM-4-3 (ETF12641)
html completed
