Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

4.4.1.21: S-ribosylhomocysteine lyase

This is an abbreviated version!
For detailed information about S-ribosylhomocysteine lyase, go to the full flat file.

Word Map on EC 4.4.1.21

Reaction

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine
=
L-homocysteine
 +
(4S)-4,5-dihydroxypentan-2,3-dione

Synonyms

AI-2 synthase, autoinducer-2 synthase, BsLuxS, EC 3.13.1.2, EC 3.2.1.148, EC 3.3.1.3, EcLuxS, lsrR, Lux S, LuxS, LuxS protein, S-ribosyl homocysteinase, S-ribosylhomocysteinase, S-ribosylhomocysteine lyase, S-ribosylhomocysteinelyase, VhLuxS

ECTree

     4 Lyases
         4.4 Carbon-sulfur lyases
             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
                4.4.1.21 S-ribosylhomocysteine lyase

Inhibitors

Inhibitors on EC 4.4.1.21 - S-ribosylhomocysteine lyase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2S)-2-amino-4-[(2R,3R)-2,3-dihydroxy-3-N-hydroxycarbamoylpropylmercapto] butyric acid
(2S)-2-amino-4-[(2R,3S)-2,3-dihydroxy-3-N-hydroxycarbamoylpropylmercapto] butyric acid
(2S)-2-amino-6-(N-formyl-N-hydroxyamino)hexanoic acid
-
Cu2+
ETF12584, ETF12641
1 mM, 6.1% of initial activity, respectively; 1 mM, 7.5% of initial activity, respectively
D-erythronohydroxamic acid
D-ribosylornithine
-
glycerol
ETF12584, ETF12641
1 mM, 0.1% of initial activity, respectively; 1 mM, 8% of initial activity, respectively
Ni2+
ETF12584, ETF12641
1 mM, 23% of initial activity, respectively; 1 mM, 7.8% of initial activity, respectively
S-(1-amino-1,4-anhydro-1,5-dideoxy-D-ribitol-5-yl)-L-homocysteine
-
inhibition of Co(II)-substituted enzyme
S-(3,5-dideoxy-3-fluoro-1-O-methyl-D-xylofuranos-5-yl)-L-homocysteine
-
S-(3,5-dideoxy-3-fluoro-D-xylofuranos-5-yl)-L-homocysteine
-
S-(3,5-dideoxy-D-erythro-pentofuranos-5-yl)homocysteine
-
S-(4-amino-4,5-dideoxy-alpha/beta-D-ribofuranos-5-yl)-L-homocysteine
-
inhibition of Co(II)-substituted enzyme. The hemiaminal may undergo ring opening to form an aldehyde which may undergo the aldose-ketose isomerization reaction to form a 2-ketone, which presumably binds to the LuxS active site with higher affinity than the original ribose analogue
S-(4-amino-4,5-dideoxy-D-ribono-1,4-lactam-5-yl)-L-homocysteine
-
inhibition of Co(II)-substituted enzyme
S-(5-deoxy-3-deoxy-3-bromo-D-xylofuranos-5-yl)-L-homocysteine
-
S-(5-deoxy-3-deoxy-3-fluoro-D-xylofuranos-5-yl)-L-homocysteine
-
S-(5-deoxy-3-O-methyl-D-ribofuranos-5-yl)homocysteine
-
S-(5-deoxy-3-O-methyl-D-xylofuranos-5-yl)homocysteine
-
S-(5-deoxy-D-xylofuranos-5-yl)-L-homocysteine
-
S-[3-bromo-3,5-dideoxy-D-ribofuranos-5-yl]-L-homocysteine
S-[3-fluoro-3,5-dideoxy-D-ribofuranos-5-yl]-L-homocysteine
Tween-20
ETF12584, ETF12641
1 mM, 85% of initial activity, respectively; 1 mM, 86% of initial activity, respectively
Zn2+
ETF12584, ETF12641
1 mM, 19.8% of initial activity, respectively; 1 mM, 19% of initial activity, respectively
additional information
5,6,7,8,9-pentadeoxy-6-fluoro-D-ribo-dec-5(Z)-enofuranuronate a S-ribosylhomocysteine analogue and 5,6-dideoxy-6-fluoro-D-ribo-hex-5-enofuranose a S-ribosylhomocysteine analogue have no inhibitory activity
-