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Literature summary for 4.4.1.21 extracted from
- Enhanced biofilm formation and reduced virulence of Actinobacillus pleuropneumoniae luxS mutant (2008), Microb. Pathog., 45, 192-200.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli DH5alpha cells | Actinobacillus pleuropneumoniae |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | a luxS deletion mutant shows obvious growth deficiency when cultured in the serum-free medium and biofilm formation is significantly enhanced, in a mouse infection model, the 50% lethal dose of the mutant strain is increased up to 96fold, and the ability to colonize in different mouse tissues is significantly decreased | Actinobacillus pleuropneumoniae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Actinobacillus pleuropneumoniae | LuxS is functional in the autoinducer-2-mediated quorum sensing and may regulate different behaviors including biofilm formation and virulence | ? | - |
? |  |
| additional information | Actinobacillus pleuropneumoniae 4074 | LuxS is functional in the autoinducer-2-mediated quorum sensing and may regulate different behaviors including biofilm formation and virulence | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Actinobacillus pleuropneumoniae | - |
- |
- |
| Actinobacillus pleuropneumoniae 4074 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | LuxS is functional in the autoinducer-2-mediated quorum sensing and may regulate different behaviors including biofilm formation and virulence | Actinobacillus pleuropneumoniae | ? | - |
? | |
| additional information | LuxS is functional in the autoinducer-2-mediated quorum sensing and may regulate different behaviors including biofilm formation and virulence | Actinobacillus pleuropneumoniae 4074 | ? | - |
? | |
| S-ribosylhomocysteine | - |
Actinobacillus pleuropneumoniae | L-homocysteine + 4,5-dihydroxy-2,3-pentanedione | - |
? | |
| S-ribosylhomocysteine | - |
Actinobacillus pleuropneumoniae 4074 | L-homocysteine + 4,5-dihydroxy-2,3-pentanedione | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LuxS | - |
Actinobacillus pleuropneumoniae |
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Release 2023.1 (January 2023)
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