4.1.3.4: hydroxymethylglutaryl-CoA lyase

This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA lyase, go to the full flat file.

Word Map on EC 4.1.3.4

4.1.3.4

3-hydroxy-3-methylglutaric

aciduria

ketogenesis

hypoglycemia

acidosis

inborn

3-methylglutaric

3-methylglutaconic

ketogenic

3-hydroxyisovaleric

hyperammonemia

hypoketotic

mevalonii

lethargy

3-methylcrotonyl-coa

medicine

acetoacetyl-coa

hl-deficient

hmgcs2

Reaction

Synonyms

3-hydroxy-3-methylglutarate-CoA lyase, 3-Hydroxy-3-methylglutaryl CoA cleaving enzyme, 3-hydroxy-3-methylglutaryl CoA lyase, 3-Hydroxy-3-methylglutaryl coenzyme A lyase, 3-Hydroxy-3-methylglutaryl-CoA lyase, 3-hydroxy-3-methylglutaryl-CoA lyase-like protein, 3-hydroxy-3-methylglutaryl-coenzyme A lyase, 3-hydroxy-methylglutaryl coenzyme A lyase, beta-hydroxy-beta-methylglutaryl-CoA lyase, HCL1, HL, HMG CoA cleavage enzyme, HMG CoA lyase, HMG-CoA lyase, HMGCL, HMGCLL1, HMGL, Hydroxymethylglutaryl coenzyme A lyase, Hydroxymethylglutaryl coenzyme A-cleaving enzyme, LiuE protein

ECTree

4 Lyases

4.1 Carbon-carbon lyases

4.1.3 Oxo-acid-lyases

4.1.3.4 hydroxymethylglutaryl-CoA lyase

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Results	in table
7	Activating Compound
12314	AA Sequence
9	Application
1	CAS Registry Number
22	Cloned(Commentary)
7	Crystallization (Commentary)
602	Disease/ Diagnostics
7	General Information
2	General Stability
5	IC50 Value
24	Inhibitors
9	Ki Value [mM]
23	KM Value [mM]
30	Localization
34	Metals/Ions
18	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
50	Organism
1	Oxidation Stability
10	Pathway
30	PDB ID
13	pH Optimum
3	pH Range
2	pI Value
1	Posttranslational Modification
80	Protein Variants
21	Purification (Commentary)
6	Reaction
2	Reaction Type
50	Reference
44	Source Tissue
48	Specific Activity [micromol/min/mg]
6	Storage Stability
46	Substrates and Products (Substrate)
14	Subunits
60	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
1	Temperature Stability [°C]
4	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 4.1.3.4 - hydroxymethylglutaryl-CoA lyase

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(-)-epicatechin gallate

Homo sapiens

a mixed-type noncompetitive inhibitor

727117

(-)-epigallocatechin

Homo sapiens

a mixed-type noncompetitive inhibitor

727117

(-)-epigallocatechin gallate

Homo sapiens

a mixed-type noncompetitive inhibitor, contribution of the gallyl moiety, which forms a hexa-coordination complex with the Mg2+ ion, to enzymatic inhibition

727117

(R)-3-hydroxy-3-methylglutaryl-CoA

Pseudomonas mevalonii

653126

1,10-phenanthroline

Pseudomonas mevalonii

43% activity after 4 h at 4 mM

653126

2-butynoyl-CoA

2 entries

3-hydroxyglutaryl-CoA

3 entries

4-Methylnitrobenzene sulfonate

Gallus gallus

sensitivity to inactivation depends on redox state of enzyme, Kinact: 0.178 min-1, reduced, 0.028 min 1, oxidized

acetoacetate

acetyldithio-CoA

EDTA

gallic acid

a noncompetitive inhibitor

727117

o-phenanthroline

Pseudomonas mevalonii

not m-Phenanthroline, probably acts as metal chelator

5375

pyrogallol

Homo sapiens

a mixed-type noncompetitive inhibitor

727117

S-(4-carboxy-3hydroxyisoamyl)-CoA

Ki: 0.08 mM

Thiomalic acid

additional information

3 entries