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4.1.3.4: hydroxymethylglutaryl-CoA lyase

This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA lyase, go to the full flat file.

Word Map on EC 4.1.3.4

Reaction

(S)-3-hydroxy-3-methylglutaryl-CoA
=
acetyl-CoA
 +
acetoacetate

Synonyms

3-hydroxy-3-methylglutarate-CoA lyase, 3-Hydroxy-3-methylglutaryl CoA cleaving enzyme, 3-hydroxy-3-methylglutaryl CoA lyase, 3-Hydroxy-3-methylglutaryl coenzyme A lyase, 3-Hydroxy-3-methylglutaryl-CoA lyase, 3-hydroxy-3-methylglutaryl-CoA lyase-like protein, 3-hydroxy-3-methylglutaryl-coenzyme A lyase, 3-hydroxy-methylglutaryl coenzyme A lyase, beta-hydroxy-beta-methylglutaryl-CoA lyase, HCL1, HL, HMG CoA cleavage enzyme, HMG CoA lyase, HMG-CoA lyase, HMGCL, HMGCLL1, HMGL, Hydroxymethylglutaryl coenzyme A lyase, Hydroxymethylglutaryl coenzyme A-cleaving enzyme, LiuE protein

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.3 Oxo-acid-lyases
                4.1.3.4 hydroxymethylglutaryl-CoA lyase

KI Value

KI Value on EC 4.1.3.4 - hydroxymethylglutaryl-CoA lyase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0441
(-)-epicatechin gallate
-
pH 7.5, 37°C
0.0299
(-)-epigallocatechin
-
pH 7.5, 37°C
0.0028
(-)-epigallocatechin gallate
-
pH 7.5, 37°C
0.05
3-hydroxyglutaryl-CoA
-
-
0.021
acetoacetate
-
-
0.17
acetyldithio-CoA
-
-
0.018
gallic acid
-
pH 7.5, 37°C
0.0074
pyrogallol
-
pH 7.5, 37°C
0.08
S-(4-carboxy-3hydroxyisoamyl)-CoA
-
-