4.1.3.4: hydroxymethylglutaryl-CoA lyase
This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA lyase, go to the full flat file.
Word Map on EC 4.1.3.4
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4.1.3.4
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3-hydroxy-3-methylglutaric
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aciduria
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ketogenesis
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hypoglycemia
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acidosis
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inborn
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3-methylglutaric
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3-methylglutaconic
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ketogenic
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3-hydroxyisovaleric
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hyperammonemia
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hypoketotic
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mevalonii
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lethargy
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3-methylcrotonyl-coa
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medicine
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acetoacetyl-coa
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hl-deficient
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hmgcs2
- 4.1.3.4
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3-hydroxy-3-methylglutaric
- aciduria
-
ketogenesis
- hypoglycemia
- acidosis
-
inborn
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3-methylglutaric
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3-methylglutaconic
-
ketogenic
-
3-hydroxyisovaleric
-
hyperammonemia
-
hypoketotic
- mevalonii
- lethargy
- 3-methylcrotonyl-coa
- medicine
- acetoacetyl-coa
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hl-deficient
- hmgcs2
Reaction
Synonyms
3-hydroxy-3-methylglutarate-CoA lyase, 3-Hydroxy-3-methylglutaryl CoA cleaving enzyme, 3-hydroxy-3-methylglutaryl CoA lyase, 3-Hydroxy-3-methylglutaryl coenzyme A lyase, 3-Hydroxy-3-methylglutaryl-CoA lyase, 3-hydroxy-3-methylglutaryl-CoA lyase-like protein, 3-hydroxy-3-methylglutaryl-coenzyme A lyase, 3-hydroxy-methylglutaryl coenzyme A lyase, beta-hydroxy-beta-methylglutaryl-CoA lyase, HCL1, HL, HMG CoA cleavage enzyme, HMG CoA lyase, HMG-CoA lyase, HMGCL, HMGCLL1, HMGL, Hydroxymethylglutaryl coenzyme A lyase, Hydroxymethylglutaryl coenzyme A-cleaving enzyme, LiuE protein
ECTree
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Specific Activity
Specific Activity on EC 4.1.3.4 - hydroxymethylglutaryl-CoA lyase
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0.123
C170S/C266S mutant protein, pH not specified in the publication, temperature not specified in the publication
0.224
C266S mutant protein, pH not specified in the publication, temperature not specified in the publication
1.06
C170S/C174S mutant protein, pH not specified in the publication, temperature not specified in the publication
123
wild type protein, pH not specified in the publication, temperature not specified in the publication
128
C234S mutant protein, pH not specified in the publication, temperature not specified in the publication
132
159
18.5
C170S/C323S mutant protein, pH not specified in the publication, temperature not specified in the publication
21.2
C197S mutant protein, pH not specified in the publication, temperature not specified in the publication
348
42
C141S mutant protein, pH not specified in the publication, temperature not specified in the publication
42.1
C174S mutant protein, pH not specified in the publication, temperature not specified in the publication
53.1
C170S mutant protein, pH not specified in the publication, temperature not specified in the publication
additional information
C307S mutant protein, pH not specified in the publication, temperature not specified in the publication
132
C323S mutant protein, pH not specified in the publication, temperature not specified in the publication
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activities per g freshweight in mitochondrial and cytosolic fractions
additional information
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enzyme activities from various enzyme deficiency patients and control individuals
additional information
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128.86 nmol/min/g of wet weight liver tissue, 58.49 nmol/min/g of wet weight pancreas tissue, 42.48 nmol/min/g of wet weight kidney tissue, 20.23 nmol/min/g of wet weight testis tissue, 12.6 nmol/min/g of wet weight skeletal muscle, activity not detected in heart and brain
additional information
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activities per g freshweight in mitochondrial and cytosolic fractions