4.1.1.32: phosphoenolpyruvate carboxykinase (GTP)

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For detailed information about phosphoenolpyruvate carboxykinase (GTP), go to the full flat file.

Reaction

Synonyms

C4 phosphoenolpyruvate carboxykinase, carboxykinase, phosphopyruvate (guanosine triphosphate), CGI_10014916, CgPCK, GDP-linked PEP carboxykinase, GTP-dependent PEPCK-C, GTP-PEPCK, GTP/ITP: oxaloacetate carboxylase (transphosphorylating), GTP/ITP:oxaloacetate carboxylyase (transphosphorylating), GTP/ITP:oxaloacetatecarboxylase (transphosphorylating), GTP:oxaloacetate carboxy-lyase, oxaloacetate kinase (decarboxylating, GDP), P-enolpyruvate carboxykinase, PCK, PCK2, PDC-E2, PEP carboxykinase, PEP carboxylase, PEP-carboxykinase, PEPC, PEPCK, PEPCK-C, PEPCK-M, phosphoenolpyruvate carboxykinase, phosphoenolpyruvate carboxykinase (GTP), phosphoenolpyruvate carboxykinase, GTP-dependent, Phosphoenolpyruvate carboxylase, phosphoenolpyruvate carboxylase (GTP), phosphoenolpyruvic carboxykinase, phosphoenolpyruvic carboxykinase (GTP), phosphoenolpyruvic carboxykinase (inosine triphosphate), Phosphoenolpyruvic carboxylase, phosphoenolpyruvic carboxylase (GTP), phosphoenolpyruvic carboxylase (inosine triphosphate), phosphopyruvate carboxykinase, phosphopyruvate carboxylase, phosphopyruvate carboxylase (GTP)

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.32 phosphoenolpyruvate carboxykinase (GTP)

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Results	in table
13	Activating Compound
14357	AA Sequence
7	Application
1	CAS Registry Number
20	Cloned(Commentary)
17	Cofactor
6	Crystallization (Commentary)
385	Disease/ Diagnostics
9	Expression
5	General Information
3	General Stability
5	IC50 Value
84	Inhibitors
10	kcat/KM [mM/s]
14	Ki Value [mM]
232	KM Value [mM]
48	Localization
73	Metals/Ions
48	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
92	Organism
1	Oxidation Stability
10	Pathway
90	PDB ID
21	pH Optimum
5	pH Range
3	pI Value
20	Protein Variants
33	Purification (Commentary)
5	Reaction
6	Reaction Type
87	Reference
82	Source Tissue
31	Specific Activity [micromol/min/mg]
11	Storage Stability
160	Substrates and Products (Substrate)
31	Subunits
93	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
37	Turnover Number [1/s]

Crystallization

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Crystallization on EC 4.1.1.32 - phosphoenolpyruvate carboxykinase (GTP)

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

hanging drop vapour diffusion method. Crystallizes in space group P21 with four molecules per asymmetric unit. The 2.3 A resolution structure is solved by molecular replacement using the human cytosolic PCK

Corynebacterium glutamicum

Q9AEM1

692636

X-ray analysis, hanging-drop method

Corynebacterium glutamicum

Q9AEM1

649210

hanging drop vapour diffusion method using 0.1 M HEPES (pH 7.4) and 19% PEG 6000

Gallus gallus

P21642

678205

enzyme alone and in complexes with the non-hydrolyzable GTP analog beta,gamma-methylene GTP, and with phosphoenolpyruvate, hanging-drop vapor-diffusion method, X-ray analysis

Homo sapiens

-

652878

hanging drop vapour diffusion method, at 25 ?C in 0.1 M HEPES (pH 7.4) and 12-30% PEG 3350, creating PEPCK-Mn2+, PEPCK-Mn2+-oxaloacetate, PEPCK-Mn2+-oxaloacetate-Mn2+GDP, and PEPCKMn2+-Mn2+GTP crystals

Rattus norvegicus

P07379

678218

mutant enzyme A467G in complex with Mn2+, substrates and inhibitors

Rattus norvegicus

P07379

714195