4.1.1.32: phosphoenolpyruvate carboxykinase (GTP)

This is an abbreviated version!
For detailed information about phosphoenolpyruvate carboxykinase (GTP), go to the full flat file.

Reaction

Synonyms

C4 phosphoenolpyruvate carboxykinase, carboxykinase, phosphopyruvate (guanosine triphosphate), CGI_10014916, CgPCK, GDP-linked PEP carboxykinase, GTP-dependent PEPCK-C, GTP-PEPCK, GTP/ITP: oxaloacetate carboxylase (transphosphorylating), GTP/ITP:oxaloacetate carboxylyase (transphosphorylating), GTP/ITP:oxaloacetatecarboxylase (transphosphorylating), GTP:oxaloacetate carboxy-lyase, oxaloacetate kinase (decarboxylating, GDP), P-enolpyruvate carboxykinase, PCK, PCK2, PDC-E2, PEP carboxykinase, PEP carboxylase, PEP-carboxykinase, PEPC, PEPCK, PEPCK-C, PEPCK-M, phosphoenolpyruvate carboxykinase, phosphoenolpyruvate carboxykinase (GTP), phosphoenolpyruvate carboxykinase, GTP-dependent, Phosphoenolpyruvate carboxylase, phosphoenolpyruvate carboxylase (GTP), phosphoenolpyruvic carboxykinase, phosphoenolpyruvic carboxykinase (GTP), phosphoenolpyruvic carboxykinase (inosine triphosphate), Phosphoenolpyruvic carboxylase, phosphoenolpyruvic carboxylase (GTP), phosphoenolpyruvic carboxylase (inosine triphosphate), phosphopyruvate carboxykinase, phosphopyruvate carboxylase, phosphopyruvate carboxylase (GTP)

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.32 phosphoenolpyruvate carboxykinase (GTP)

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Results	in table
13	Activating Compound
14357	AA Sequence
7	Application
1	CAS Registry Number
20	Cloned(Commentary)
17	Cofactor
6	Crystallization (Commentary)
385	Disease/ Diagnostics
9	Expression
5	General Information
3	General Stability
5	IC50 Value
84	Inhibitors
10	kcat/KM [mM/s]
14	Ki Value [mM]
232	KM Value [mM]
48	Localization
73	Metals/Ions
48	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
92	Organism
1	Oxidation Stability
10	Pathway
90	PDB ID
21	pH Optimum
5	pH Range
3	pI Value
20	Protein Variants
33	Purification (Commentary)
5	Reaction
6	Reaction Type
87	Reference
82	Source Tissue
31	Specific Activity [micromol/min/mg]
11	Storage Stability
160	Substrates and Products (Substrate)
31	Subunits
93	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
37	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 4.1.1.32 - phosphoenolpyruvate carboxykinase (GTP)

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

GDP + phosphoenolpyruvate + CO2

GTP + oxaloacetate

3 entries

GTP + oxaloacetate

?

4 entries

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

21 entries

ITP + oxaloacetate

IDP + phosphoenolpyruvate + CO2

2 entries

GDP + phosphoenolpyruvate + CO2

GTP + oxaloacetate

Acetivibrio thermocellus

-

-

726738

-

-

?

GDP + phosphoenolpyruvate + CO2

GTP + oxaloacetate

Acetivibrio thermocellus DSM 1313

-

-

726738

-

-

?

GDP + phosphoenolpyruvate + CO2

GTP + oxaloacetate

Raillietina echinobothrida

-

highest activity

728430

-

-

?

GTP + oxaloacetate

?

Corynebacterium glutamicum

-

enzyme mainly functions in gluconeogenesis

4368

-

-

?

GTP + oxaloacetate

?

Gallus gallus

-

first commited step of gluconeogenesis

4367

-

-

?

GTP + oxaloacetate

?

Rattus norvegicus

-

induced by a combination of dibutyryl cAMP, theophylline, and dexamethasone

4364

-

-

?

GTP + oxaloacetate

?

Rattus norvegicus

-

first commited step of gluconeogenesis

4367

-

-

?

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Anaerobiospirillum succiniciproducens

-

decarboxylation of oxaloacetate is the physiological important reaction

653038

-

653038

?

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Ascaris suum

-

-

649467

-

649467

?

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Bos taurus

-

pace-setting enzyme in gluconeogenesis

653433

-

653433

?

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Corynebacterium glutamicum

Q9AEM1

key enzyme involved in the regulation of gluconeogenesis

649210

-

649210

?

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Corynebacterium glutamicum

-

key rate-limiting step in the gluconeogenic pathway, plays a role in the production of glutamine and lysine through the TCA cycle intermediates

653770

-

653770

?

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Gallus gallus

-

-

727092

-

-

?

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Gallus gallus

-

committed step in gluconeogenesis

649936

-

649936

?

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Gallus gallus

-

primary role is the formation of phosphoenolpyruvate in the first committed step of gluconeogenesis

650021

-

650021

?

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Gallus gallus

-

first committed step of gluconeogenesis

667608

-

-

r

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Homo sapiens

-

catalyzes the rate-limiting step in gluconeogenesis

650567

-

650567

?

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Homo sapiens

-

catalyzes the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle

652878

-

652878

?

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Homo sapiens

-

key enzyme of gluconeogenesis, involved in lipid homeostasis

667839

-

-

?

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Mycolicibacterium smegmatis

Q9AGJ6

catalyzes the first committed step in gluconeogenesis, in vivo enzyme prefers the gluconeogenesis/glycerogenesis direction, i.e phosphoenolpyruvate formation, GDP is the more physiologically relevant nucleotide substrate than IDP

652113

-

652113

r

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Mycolicibacterium smegmatis mc(2)155

Q9AGJ6

catalyzes the first committed step in gluconeogenesis, in vivo enzyme prefers the gluconeogenesis/glycerogenesis direction, i.e phosphoenolpyruvate formation, GDP is the more physiologically relevant nucleotide substrate than IDP

652113

-

652113

r

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Psammomys obesus

-

first committed step of gluconeogenesis

670131

-

-

?

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Rattus norvegicus

-

-

704540, 727993

-

-

?

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Rattus norvegicus

-

catalyzes the rate-limiting step in gluconeogenesis, PEPCK expression and growth arrest may be coordinately regulated

649586

-

649586

?

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Rattus norvegicus

-

primary role is the formation of phosphoenolpyruvate in the first committed step of gluconeogenesis

650021

-

650021

?

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Rattus norvegicus

-

first committed step of gluconeogenesis

668962

-

-

?

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Thermococcus kodakarensis

Q6F494

first committed step of gluconeogenesis, important enzyme in the interconversion between C3 and C4 metabolites, recycling of an excess of phosphoenolpyruvate produced from pyruvate

669085

-

-

r

GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2

Thermococcus kodakarensis

Q6F494

one of the important enzymes in the interconversion between C3 and C4 metabolites. It provides phosphoenolpyruvate from oxaloacetate as the first step of gluconeogenesis. The enzyme plays an additional role in the recycling of excess phosphoenolpyruvate produced from pyruvate, replacing the function of the anaplerotic phosphoenolpyruvate carboxylase that is missing from this archaeon

669085

-

-

r

ITP + oxaloacetate

IDP + phosphoenolpyruvate + CO2

Gallus gallus

-

-

667608

-

-

r

ITP + oxaloacetate

IDP + phosphoenolpyruvate + CO2

Rattus norvegicus

-

rate limiting enzyme of gluconeogenesis

669990

-

-

?