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4.1.1.32: phosphoenolpyruvate carboxykinase (GTP)

This is an abbreviated version!
For detailed information about phosphoenolpyruvate carboxykinase (GTP), go to the full flat file.

Word Map on EC 4.1.1.32

Reaction

GTP
+
oxaloacetate
=
GDP
 +
phosphoenolpyruvate
 +
CO2

Synonyms

C4 phosphoenolpyruvate carboxykinase, carboxykinase, phosphopyruvate (guanosine triphosphate), CGI_10014916, CgPCK, GDP-linked PEP carboxykinase, GTP-dependent PEPCK-C, GTP-PEPCK, GTP/ITP: oxaloacetate carboxylase (transphosphorylating), GTP/ITP:oxaloacetate carboxylyase (transphosphorylating), GTP/ITP:oxaloacetatecarboxylase (transphosphorylating), GTP:oxaloacetate carboxy-lyase, oxaloacetate kinase (decarboxylating, GDP), P-enolpyruvate carboxykinase, PCK, PCK2, PDC-E2, PEP carboxykinase, PEP carboxylase, PEP-carboxykinase, PEPC, PEPCK, PEPCK-C, PEPCK-M, phosphoenolpyruvate carboxykinase, phosphoenolpyruvate carboxykinase (GTP), phosphoenolpyruvate carboxykinase, GTP-dependent, Phosphoenolpyruvate carboxylase, phosphoenolpyruvate carboxylase (GTP), phosphoenolpyruvic carboxykinase, phosphoenolpyruvic carboxykinase (GTP), phosphoenolpyruvic carboxykinase (inosine triphosphate), Phosphoenolpyruvic carboxylase, phosphoenolpyruvic carboxylase (GTP), phosphoenolpyruvic carboxylase (inosine triphosphate), phosphopyruvate carboxykinase, phosphopyruvate carboxylase, phosphopyruvate carboxylase (GTP)

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.32 phosphoenolpyruvate carboxykinase (GTP)

Expression

Expression on EC 4.1.1.32 - phosphoenolpyruvate carboxykinase (GTP)

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha. Isonicotinamide decreases the level of mRNA for PEPCK-C
activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha. Isonicotinamide decreases the level of mRNA for PEPCK-C with an IC50 of 2.3 mM
-
after the stimulations with lipopolysaccharide, peptidoglycan, Vibrio splendidus and Vibrio anguillarum, PEPCK transcripts in hemocytes are significantly upregulated
higher expression levels under gluconeogenic conditions
phenobarbital directly suppresses PEPCK gene expression in spherical hepatocytes on EHS-gel, but not in those on type I collagen. Phenobarbital strongly suppresses cAMP-dependent induction of PEPCK gene expression
-
the pck mRNA level is higher when cells are grown on lactose than on glucose
-
there is a significant increase of 85% in kidney PEPCK activity of diabetic rats 0.85 units/g tissue/min in comparison to the 0.46 units/g tissue/min of normal controls, treatment of diabetic animals with cinnamaldehyde and glibenclamide for 60 days prevents the increase in PEPCK levels
-
there is no effect of fish meal and fish oil substitution on hepatic levels of mitochondrial PEPCK mRNA