4.1.1.32: phosphoenolpyruvate carboxykinase (GTP)

This is an abbreviated version!
For detailed information about phosphoenolpyruvate carboxykinase (GTP), go to the full flat file.

Word Map on EC 4.1.1.32

4.1.1.32

biliary

cirrhosis

gluconeogenesis

autoantigens

autoimmune

gluconeogenic

autoantibody

epitope

lipoylated

antimitochondrial

camp

glucocorticoid

bile

immunodominant

malate

malic

autoreactive

cholangitis

intrahepatic

lipoic

autoepitope

glyceroneogenesis

dibutyryl

6.4.1.1

anaplerotic

3-mercaptopicolinic

2.7.1.40

bt2camp

pbc-specific

fto-2b

oxalacetate

2-oxo-acid

ama-positive

dihydrolipoamide

self-tolerance

drug development

synthesis

pharmacology

medicine

Reaction

Synonyms

C4 phosphoenolpyruvate carboxykinase, carboxykinase, phosphopyruvate (guanosine triphosphate), CGI_10014916, CgPCK, GDP-linked PEP carboxykinase, GTP-dependent PEPCK-C, GTP-PEPCK, GTP/ITP: oxaloacetate carboxylase (transphosphorylating), GTP/ITP:oxaloacetate carboxylyase (transphosphorylating), GTP/ITP:oxaloacetatecarboxylase (transphosphorylating), GTP:oxaloacetate carboxy-lyase, oxaloacetate kinase (decarboxylating, GDP), P-enolpyruvate carboxykinase, PCK, PCK2, PDC-E2, PEP carboxykinase, PEP carboxylase, PEP-carboxykinase, PEPC, PEPCK, PEPCK-C, PEPCK-M, phosphoenolpyruvate carboxykinase, phosphoenolpyruvate carboxykinase (GTP), phosphoenolpyruvate carboxykinase, GTP-dependent, Phosphoenolpyruvate carboxylase, phosphoenolpyruvate carboxylase (GTP), phosphoenolpyruvic carboxykinase, phosphoenolpyruvic carboxykinase (GTP), phosphoenolpyruvic carboxykinase (inosine triphosphate), Phosphoenolpyruvic carboxylase, phosphoenolpyruvic carboxylase (GTP), phosphoenolpyruvic carboxylase (inosine triphosphate), phosphopyruvate carboxykinase, phosphopyruvate carboxylase, phosphopyruvate carboxylase (GTP)

ECTree

4 Lyases

4.1 Carbon-carbon lyases

4.1.1 Carboxy-lyases

4.1.1.32 phosphoenolpyruvate carboxykinase (GTP)

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Results	in table
13	Activating Compound
14357	AA Sequence
7	Application
1	CAS Registry Number
20	Cloned(Commentary)
17	Cofactor
6	Crystallization (Commentary)
385	Disease/ Diagnostics
9	Expression
5	General Information
3	General Stability
5	IC50 Value
84	Inhibitors
10	kcat/KM [mM/s]
14	Ki Value [mM]
232	KM Value [mM]
48	Localization
73	Metals/Ions
48	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
92	Organism
1	Oxidation Stability
10	Pathway
90	PDB ID
21	pH Optimum
5	pH Range
3	pI Value
20	Protein Variants
33	Purification (Commentary)
5	Reaction
6	Reaction Type
87	Reference
82	Source Tissue
31	Specific Activity [micromol/min/mg]
11	Storage Stability
160	Substrates and Products (Substrate)
31	Subunits
93	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
37	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 4.1.1.32 - phosphoenolpyruvate carboxykinase (GTP)

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2-mercaptoethanol

Mycolicibacterium smegmatis

Q9AGJ6

maximum stimulation at 75 mM

652113

dithiothreitol

Mycolicibacterium smegmatis

Q9AGJ6

maximum at 10-40 mM, 30% stimulation

652113

Ferroactivator

Rattus norvegicus

ferroactivator + Fe2+, stimulates both directions of the reaction

4356

ITP

Ovis aries

stimulates Mn2+-dependent CO2-oxaloacetate exchange

4344

Mn2+

Homo sapiens

activity regulator, 0.7 mM leads to full enzyme stimulation

678421

reduced glutathione

Mycolicibacterium smegmatis

Q9AGJ6

maximum stimulation at 20 mM

652113

thiol-containing reducing agent

Mycolicibacterium smegmatis

Q9AGJ6

activates

652113

additional information

7 entries