4.1.1.32: phosphoenolpyruvate carboxykinase (GTP)
This is an abbreviated version!
For detailed information about phosphoenolpyruvate carboxykinase (GTP), go to the full flat file.
Word Map on EC 4.1.1.32
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4.1.1.32
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biliary
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cirrhosis
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gluconeogenesis
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autoantigens
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autoimmune
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gluconeogenic
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autoantibody
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epitope
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lipoylated
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antimitochondrial
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camp
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glucocorticoid
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bile
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immunodominant
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malate
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malic
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autoreactive
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cholangitis
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intrahepatic
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lipoic
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autoepitope
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glyceroneogenesis
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dibutyryl
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6.4.1.1
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anaplerotic
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3-mercaptopicolinic
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2.7.1.40
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bt2camp
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pbc-specific
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fto-2b
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oxalacetate
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2-oxo-acid
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ama-positive
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dihydrolipoamide
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self-tolerance
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drug development
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synthesis
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pharmacology
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medicine
- 4.1.1.32
- biliary
- cirrhosis
-
gluconeogenesis
- autoantigens
- autoimmune
-
gluconeogenic
- autoantibody
- epitope
-
lipoylated
-
antimitochondrial
- camp
- glucocorticoid
- bile
-
immunodominant
- malate
-
malic
-
autoreactive
- cholangitis
-
intrahepatic
-
lipoic
-
autoepitope
-
glyceroneogenesis
-
dibutyryl
-
6.4.1.1
-
anaplerotic
-
3-mercaptopicolinic
-
2.7.1.40
-
bt2camp
-
pbc-specific
-
fto-2b
- oxalacetate
- 2-oxo-acid
-
ama-positive
- dihydrolipoamide
-
self-tolerance
- drug development
- synthesis
- pharmacology
- medicine
Reaction
Synonyms
C4 phosphoenolpyruvate carboxykinase, carboxykinase, phosphopyruvate (guanosine triphosphate), CGI_10014916, CgPCK, GDP-linked PEP carboxykinase, GTP-dependent PEPCK-C, GTP-PEPCK, GTP/ITP: oxaloacetate carboxylase (transphosphorylating), GTP/ITP:oxaloacetate carboxylyase (transphosphorylating), GTP/ITP:oxaloacetatecarboxylase (transphosphorylating), GTP:oxaloacetate carboxy-lyase, oxaloacetate kinase (decarboxylating, GDP), P-enolpyruvate carboxykinase, PCK, PCK2, PDC-E2, PEP carboxykinase, PEP carboxylase, PEP-carboxykinase, PEPC, PEPCK, PEPCK-C, PEPCK-M, phosphoenolpyruvate carboxykinase, phosphoenolpyruvate carboxykinase (GTP), phosphoenolpyruvate carboxykinase, GTP-dependent, Phosphoenolpyruvate carboxylase, phosphoenolpyruvate carboxylase (GTP), phosphoenolpyruvic carboxykinase, phosphoenolpyruvic carboxykinase (GTP), phosphoenolpyruvic carboxykinase (inosine triphosphate), Phosphoenolpyruvic carboxylase, phosphoenolpyruvic carboxylase (GTP), phosphoenolpyruvic carboxylase (inosine triphosphate), phosphopyruvate carboxykinase, phosphopyruvate carboxylase, phosphopyruvate carboxylase (GTP)
ECTree
4.1.1.32 phosphoenolpyruvate carboxykinase (GTP)Advanced search results
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results (Substrates Products
Substrates Products on EC 4.1.1.32 - phosphoenolpyruvate carboxykinase (GTP)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2'-deoxyguanosine 5'-triphosphate + oxaloacetate
2'-deoxyguanosine 5'-diphosphate + phosphoenolpyruvate + CO2
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2-deoxyGTP is a less effective substrate than GTP, 2-deoxyGTP binds to enzyme less tight than 2-deoxyGDP
2-deoxyGDP is a less effective substrate than GDP in the reverse reaction
?
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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the enzyme can also use ATP instead of GTP for oxaloacetate decarboxylation
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-
ir
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
poor substrate
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-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
poor activity
-
-
r
GDP + phosphoenolpyruvate + CO2
GTP + oxaloacetate
-
-
-
-
?
GDP + phosphoenolpyruvate + CO2
GTP + oxaloacetate
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highest activity
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-
?
GTP + oxaloacetate
?
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enzyme mainly functions in gluconeogenesis
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-
?
GTP + oxaloacetate
?
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induced by a combination of dibutyryl cAMP, theophylline, and dexamethasone
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-
?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
-
role of His-225 and Asp-263 in phosphoenolpyruvate binding
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r
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
-
decarboxylation of oxaloacetate is the physiological important reaction
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?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
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Cys-306 is important in nucleotide binding and may interact with the 2-OH group in the ribose ring. GTP binds to enzyme tighter than GDP
GDP is a slightly more favorable substrate than IDP in the reverse reaction
r
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
-
pace-setting enzyme in gluconeogenesis
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?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
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reaction with GTP is not reported
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-
?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
specific for GTP
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r
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
-
GTP-specific
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r
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
key enzyme involved in the regulation of gluconeogenesis
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?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
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key rate-limiting step in the gluconeogenic pathway, plays a role in the production of glutamine and lysine through the TCA cycle intermediates
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?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
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metal-nucleotide complex serves as substrate, active site structure, a conformational change at the active site occurs during catalysis
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r
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
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specifically requires GTP or ITP, structural data of GTP binding
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r
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
-
committed step in gluconeogenesis
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?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
-
primary role is the formation of phosphoenolpyruvate in the first committed step of gluconeogenesis
-
?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
-
first committed step of gluconeogenesis
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-
r
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
-
GTP-dependent, enzyme and GTP-binding site structure
phosphoenolpyruvate binds as a 1:1 complex with Na+, structure of the phosphoenolpyruvate-binding site
r
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
-
catalyzes the rate-limiting step in gluconeogenesis
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?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
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catalyzes the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle
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?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
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key enzyme of gluconeogenesis, involved in lipid homeostasis
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-
?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
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-
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r
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
GTP-dependent, enzyme prefers the phosphoenolpyruvate synthesis direction
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r
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
catalyzes the first committed step in gluconeogenesis, in vivo enzyme prefers the gluconeogenesis/glycerogenesis direction, i.e phosphoenolpyruvate formation, GDP is the more physiologically relevant nucleotide substrate than IDP
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r
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
GTP-dependent, enzyme prefers the phosphoenolpyruvate synthesis direction
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r
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
catalyzes the first committed step in gluconeogenesis, in vivo enzyme prefers the gluconeogenesis/glycerogenesis direction, i.e phosphoenolpyruvate formation, GDP is the more physiologically relevant nucleotide substrate than IDP
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r
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
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first committed step of gluconeogenesis
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-
?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
-
-
-
-
?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
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specifically requires GTP or ITP, structural data of GTP binding
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r
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
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catalyzes the rate-limiting step in gluconeogenesis, PEPCK expression and growth arrest may be coordinately regulated
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?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
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primary role is the formation of phosphoenolpyruvate in the first committed step of gluconeogenesis
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?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
-
first committed step of gluconeogenesis
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-
?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
physiological direction of reaction
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-
r
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
-
-
-
?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
interacts also with ATP, EC 4.1.1.49
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-
?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
first committed step of gluconeogenesis, important enzyme in the interconversion between C3 and C4 metabolites, recycling of an excess of phosphoenolpyruvate produced from pyruvate
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r
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
one of the important enzymes in the interconversion between C3 and C4 metabolites. It provides phosphoenolpyruvate from oxaloacetate as the first step of gluconeogenesis. The enzyme plays an additional role in the recycling of excess phosphoenolpyruvate produced from pyruvate, replacing the function of the anaplerotic phosphoenolpyruvate carboxylase that is missing from this archaeon
-
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r
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
the enzyme prefers phosphoenolpyruvate formation from oxaloacetate
-
-
r
IDP + phosphoenolpyruvate + CO2
ITP + oxaloacetate
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lower activity compared to GDP
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-
?
ITP + oxaloacetate
IDP + phosphoenolpyruvate + CO2
-
-
GDP is a slightly more favorable substrate than IDP in the reverse reaction
r
ITP + oxaloacetate
IDP + phosphoenolpyruvate + CO2
-
lower activity with IDP than with GDP in the reverse reaction
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r
ITP + oxaloacetate
IDP + phosphoenolpyruvate + CO2
-
specifically requires GTP or ITP
-
r
ITP + oxaloacetate
IDP + phosphoenolpyruvate + CO2
-
-
r
ITP + oxaloacetate
IDP + phosphoenolpyruvate + CO2
-
-
r
ITP + oxaloacetate
IDP + phosphoenolpyruvate + CO2
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specifically requires GTP or ITP
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r
ITP + oxaloacetate
IDP + phosphoenolpyruvate + CO2
-
rate limiting enzyme of gluconeogenesis
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-
?
ITP + oxaloacetate
IDP + phosphoenolpyruvate + CO2
ITP and IDP act as alternative nucleotide cofactors with similar Vmax values and slightly higher Km values
-
-
r
UDP + phosphoenolpyruvate + CO2
UTP + oxaloacetate
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very low activity
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?
UDP + phosphoenolpyruvate + CO2
UTP + oxaloacetate
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very low activity
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?
additional information
?
-
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catalyzes bicarbonate-dependent phosphorylation of hydroxylamine
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-
?
additional information
?
-
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enzyme catalyzes the phosphorylation of glycolate, thioglycolate, and DL-beta-chloroacetate
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-
?
additional information
?
-
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catalyzes an exchange reaction between HCO3- and the beta-carboxyl group of oxaloacetate
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-
?
additional information
?
-
-
ADP is completely inactive in carboxylation of oxaloacetate
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-
?
additional information
?
-
-
ADP is completely inactive in carboxylation of oxaloacetate
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-
?
additional information
?
-
ADP is a very poor substrate in the reverse reaction
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?
additional information
?
-
ADP is a very poor substrate in the reverse reaction
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?
additional information
?
-
-
Mn2+-dependent CO2-oxaloacetate exchange in absence of added nucleotide
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-
?
additional information
?
-
-
no enzyme activity observed when ADP or CDP is used
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-
?
additional information
?
-
-
catalyzes bicarbonate-dependent phosphorylation of hydroxylamine
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-
?
additional information
?
-
-
enzyme catalyzes the phosphorylation of glycolate, thioglycolate, and DL-beta-chloroacetate
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-
?
additional information
?
-
-
PCK shows no phosphoenolpyruvate-carboxylating activity
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-
?
