Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

4.1.1.32: phosphoenolpyruvate carboxykinase (GTP)

This is an abbreviated version!
For detailed information about phosphoenolpyruvate carboxykinase (GTP), go to the full flat file.

Word Map on EC 4.1.1.32

Reaction

GTP
+
oxaloacetate
=
GDP
+
phosphoenolpyruvate
+
CO2

Synonyms

C4 phosphoenolpyruvate carboxykinase, carboxykinase, phosphopyruvate (guanosine triphosphate), CGI_10014916, CgPCK, GDP-linked PEP carboxykinase, GTP-dependent PEPCK-C, GTP-PEPCK, GTP/ITP: oxaloacetate carboxylase (transphosphorylating), GTP/ITP:oxaloacetate carboxylyase (transphosphorylating), GTP/ITP:oxaloacetatecarboxylase (transphosphorylating), GTP:oxaloacetate carboxy-lyase, oxaloacetate kinase (decarboxylating, GDP), P-enolpyruvate carboxykinase, PCK, PCK2, PDC-E2, PEP carboxykinase, PEP carboxylase, PEP-carboxykinase, PEPC, PEPCK, PEPCK-C, PEPCK-M, phosphoenolpyruvate carboxykinase, phosphoenolpyruvate carboxykinase (GTP), phosphoenolpyruvate carboxykinase, GTP-dependent, Phosphoenolpyruvate carboxylase, phosphoenolpyruvate carboxylase (GTP), phosphoenolpyruvic carboxykinase, phosphoenolpyruvic carboxykinase (GTP), phosphoenolpyruvic carboxykinase (inosine triphosphate), Phosphoenolpyruvic carboxylase, phosphoenolpyruvic carboxylase (GTP), phosphoenolpyruvic carboxylase (inosine triphosphate), phosphopyruvate carboxykinase, phosphopyruvate carboxylase, phosphopyruvate carboxylase (GTP)

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.32 phosphoenolpyruvate carboxykinase (GTP)

Inhibitors

Inhibitors on EC 4.1.1.32 - phosphoenolpyruvate carboxykinase (GTP)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(Z)-Phosphoenol-3-bromopyruvate
-
linear competitive
1-allyl-3-butyl-8-methylxanthine
-
weak, competitive inhibitor with respect to GTP, IC50: 0.225 mM in the decarboxylation direction, modifications at N-1 and C-8 improve the inhibitory activity by more than 100fold
2,3-Butanedione
-
-
2-oxobutanoate
-
weak
2-oxoglutarate
2-Phosphoglycolate
-
3-Aminopicolinic acid
Modiolus demissus
-
-
3-Mercaptopicolinic acid
3-Nitro-2-oxopropionic acid
-
weak
5,5'-dithiobis(2-nitrobenzoate)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
inhibits wild-type enzyme, but not C306A or C306S mutant enzymes
8-azidoguanosine 5'-triphosphate
-
photoinactivation is caused by formation of an intramolecular cystine disulfide bridge
Acetopyruvate
-
weak noncompetitive
ADP
Modiolus demissus
-
uncompetitive with respect to IDP, partially competitive with respect to phosphoenolpyruvate
alpha-(Dihydroxyphosphinylmethyl) acrylic acid
-
weak linear competitive
alpha-ketoglutarate
inhibits oxaloacetate formation, mixed-type inhibition
beta-sulfopyruvate
citrate
-
above 5.0 mM, weak
Co3+-GDP
-
competitive inhibitor
Co3+-GTP
-
competitive inhibitor
Cr3+-GDP
-
competitive inhibitor
Cr3+-GTP
-
competitive inhibitor
dithiothreitol
-
5 mM, 19% inhibition
DL-3-Nitro-2-hydroxypropionic acid
-
weak
DL-isocitrate
-
above 5.0 mM, weak
EDTA
-
0.5 mM, 86% inhibition
FeCl2
-
1.5 mM FeCl2 causes rapid inactivation. 0.05 mM FeCl2 and 0.0044 mg/ml ferroactivator, enhance to 3.1times the unstimulated rate
glycerate
-
D-glycerate, L-glycerate and DL-glycerate, weak noncompetitive
GTP
-
competitive inhibitor
Hydroxymalonate
Modiolus demissus
-
slight
IMP
-
competitive inhibitor
interleukin-10
-
added to cell culture medium in combination with interleukin-1beta, reduces mRNA and enzyme level
-
interleukin-1beta
-
added to cell culture medium in combination with interleukin-10, reduces mRNA and enzyme level
-
iodoacetamide
iodoacetate
-
-
KHCO3
-
above 0.1 M inhibits the oxaloacetate-forming activity
malate
malonate
-
weak
Mg2+
-
Mg2+ reduces mitochondrial PEPCK activity
MgCl2
-
1.5 mM, 62% inhibition
N'1-([5-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-2-thienyl]methylidene)-2,4-dichlorobenzene-1-carbohydrazide
-
compound exhibits significantly different inhibitory effects on wild-type and natural variant M139L, it enhances threefold the apparent Km value for GTP in wild-type, and reduces Km value for M139L from 99 to 69 microM
oxalate
pyruvate
weak inhibition
quinolinic acid
-
strongly inhibits the enzyme activated by ferroactivator and Fe2+, no inhibition of Mn2+-activated enzyme
succinate
-
above 5.0 mM, weak
Tartronate
-
weak
additional information
-