4.1.1.32: phosphoenolpyruvate carboxykinase (GTP)

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For detailed information about phosphoenolpyruvate carboxykinase (GTP), go to the full flat file.

Reaction

Synonyms

C4 phosphoenolpyruvate carboxykinase, carboxykinase, phosphopyruvate (guanosine triphosphate), CGI_10014916, CgPCK, GDP-linked PEP carboxykinase, GTP-dependent PEPCK-C, GTP-PEPCK, GTP/ITP: oxaloacetate carboxylase (transphosphorylating), GTP/ITP:oxaloacetate carboxylyase (transphosphorylating), GTP/ITP:oxaloacetatecarboxylase (transphosphorylating), GTP:oxaloacetate carboxy-lyase, oxaloacetate kinase (decarboxylating, GDP), P-enolpyruvate carboxykinase, PCK, PCK2, PDC-E2, PEP carboxykinase, PEP carboxylase, PEP-carboxykinase, PEPC, PEPCK, PEPCK-C, PEPCK-M, phosphoenolpyruvate carboxykinase, phosphoenolpyruvate carboxykinase (GTP), phosphoenolpyruvate carboxykinase, GTP-dependent, Phosphoenolpyruvate carboxylase, phosphoenolpyruvate carboxylase (GTP), phosphoenolpyruvic carboxykinase, phosphoenolpyruvic carboxykinase (GTP), phosphoenolpyruvic carboxykinase (inosine triphosphate), Phosphoenolpyruvic carboxylase, phosphoenolpyruvic carboxylase (GTP), phosphoenolpyruvic carboxylase (inosine triphosphate), phosphopyruvate carboxykinase, phosphopyruvate carboxylase, phosphopyruvate carboxylase (GTP)

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.32 phosphoenolpyruvate carboxykinase (GTP)

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Results	in table
13	Activating Compound
14357	AA Sequence
7	Application
1	CAS Registry Number
20	Cloned(Commentary)
17	Cofactor
6	Crystallization (Commentary)
385	Disease/ Diagnostics
9	Expression
5	General Information
3	General Stability
5	IC50 Value
84	Inhibitors
10	kcat/KM [mM/s]
14	Ki Value [mM]
232	KM Value [mM]
48	Localization
73	Metals/Ions
48	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
92	Organism
1	Oxidation Stability
10	Pathway
90	PDB ID
21	pH Optimum
5	pH Range
3	pI Value
20	Protein Variants
33	Purification (Commentary)
5	Reaction
6	Reaction Type
87	Reference
82	Source Tissue
31	Specific Activity [micromol/min/mg]
11	Storage Stability
160	Substrates and Products (Substrate)
31	Subunits
93	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
37	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 4.1.1.32 - phosphoenolpyruvate carboxykinase (GTP)

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.225

1-allyl-3-butyl-8-methylxanthine

Homo sapiens

-

weak, competitive inhibitor with respect to GTP, IC50: 0.225 mM in the decarboxylation direction, modifications at N-1 and C-8 improve the inhibitory activity by more than 100fold

650567

0.02 - 0.065

3-Mercaptopicolinic acid

2 entries

0.3

KHCO3

Homo sapiens

-

-

678421

9.3

L-alanine

Crassostrea gigas

Q0KHB7

in 100 mM imidazole-HCl buffer (pH 6.6), at 30°C

681148

0.02

3-Mercaptopicolinic acid

Homo sapiens

-

reversible, non-competitive inhibitor, IC50: in the 0.02 mM range

650567

0.065

3-Mercaptopicolinic acid

Sus scrofa

-

wild-type, pH 7.4, temperature not specified in the publication

749089