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3.5.1.98: histone deacetylase

This is an abbreviated version!
For detailed information about histone deacetylase, go to the full flat file.

Word Map on EC 3.5.1.98

Reaction

hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone =

Synonyms

acetyl-lysine deacetylase, AhHDA1, AtHD1, class I acetyl-lysine deacetylase, class I HDAC, class I histone deacetylase, class II Hda1 HDAC, class II histone deacetylase, class IIa HDAC, class IIa histone deacetylase, Clr6, cytoplasmic deacetylase, deacetylase-like amidohydrolase, dRPD3, FB188 HDAH, Glyma.01 g245100, Glyma.04 g000200, Glyma.04 g187000, Glyma.04 g187100, Glyma.05 g012900, Glyma.05 g021400, Glyma.05 g040600, Glyma.05 g192600, Glyma.06 g000100, Glyma.06 g178700, Glyma.11 g000300, Glyma.11 g187800, Glyma.12 g086700, Glyma.12 g188200, Glyma.17 g078000, Glyma.17 g085700, Glyma.17 g120900, Glyma.17 g229600, GmHDA1, GmHDA10, GmHDA11, GmHDA12, GmHDA13, GmHDA14, GmHDA15, GmHDA16, GmHDA17, GmHDA18, GmHDA2, GmHDA3, GmHDA4, GmHDA5, GmHDA6, GmHDA7, GmHDA8, GmHDA9, GmHDAC, HD1B, HD2, HD8, HDA, HDA-1, HDA-2, HDA-3, HDA-4, hda1, HDA15, HDA19, HDA9, HdaA, HDAC, HDAC 11, HDAC 3, HDAC1, HDAC10, HDAC2, HDAC2-1, HDAC2-2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC6p114, HDAC6p131, HDAC7, HDAC8, HDAC9, HDAH, HDLP, HDT1, HDT2, histone deacetylase, histone deacetylase 1, histone deacetylase 10, histone deacetylase 11, histone deacetylase 2, histone deacetylase 3, histone deacetylase 4, histone deacetylase 6, histone deacetylase 7, histone deacetylase 8, histone deacetylase-1, histone deacetylase-7, histone deacetylase-like amidohydrolase, histone deacetylase-like protein, histone deacetylase1, Hos2, HosB, PA3774, pfHDAC-1, RPD3, Set3 complex, Set3C, tubulin deacetylase, zinc-dependent histone deacetylase, Zn(II)-dependent deacetylase, Zn-HDAC

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.98 histone deacetylase

Turnover Number

Turnover Number on EC 3.5.1.98 - histone deacetylase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.19
Ac-Leu-Gly-Lys(Ac)-7-amido-4-methylcoumarin
-
0.0019 - 0.29
Fluor de Lys
-
0.0002 - 1.1
Fluor de Lys HDAC substrate
-
0.007 - 1.2
Fluor de Lys HDAC8 substrate
-
1.09
GGK(Ac)FF
pH 7.4, 37°C, recombinant enzyme
1.88
GK(Ac)F
pH 7.4, 37°C, recombinant enzyme
1.53
RGGK(Ac)FFR
pH 7.4, 37°C, recombinant enzyme
0.48 - 1.2
RHK(acetyl)K(acetyl)-fluorophore
0.92
RYSSRRK(Ac)ARPYML
pH 7.4, 37°C, recombinant enzyme
0.02
SQSEEEK(Ac)FFRRFP
pH 7.4, 37°C, recombinant enzyme
2.28
SRGGK(Ac)FFRR
pH 7.4, 37°C, recombinant enzyme
0.71
TYSRGGK(Ac)FFRRFP
pH 7.4, 37°C, recombinant enzyme
0.12
TYSRGGK(Ac)KSEESE
pH 7.4, 37°C, recombinant enzyme
1.66
YSRGGK(Ac)FFRRF
pH 7.4, 37°C, recombinant enzyme