Cloned (Comment) | Organism |
---|---|
expression in baculoviral system, His-tagged protein | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
H216A | mutation in the first catalytic domain of enzyme, slight decrease in catalytic rate | Homo sapiens |
H611A | mutation in second catalytic domain of enzyme, more than 5000fold decrease in catalytic rate | Homo sapiens |
additional information | enzyme contains two potentially functional catalytic domains. Expression of first domain alone does not result in catalytic activity. The catalytic domain II alone shows only a modest decrease in substrate binding and product formation rate compared to wild-type | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000015 | - |
Fluor de Lys | mt H611A, pH 7.2, 23°C | Homo sapiens | |
0.0024 | - |
Fluor de Lys | catalytic domain II, pH 7.2, 23°C | Homo sapiens | |
0.0033 | - |
Fluor de Lys | wild-type, pH 7.2, 23°C | Homo sapiens | |
0.0038 | - |
Fluor de Lys | mutant H216A, pH 7.2, 23°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UBN7 | isoform HDAC6, contains two potentially functional catalytic domains | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Fluor de Lys + H2O | - |
Homo sapiens | ? | - |
? | |
RHK(acetyl)K(acetyl)-fluorophore + H2O | i.e. Fluor de Lys, fluorogenic substrate | Homo sapiens | RHKK-fluorophore + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HDAC6 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0019 | - |
Fluor de Lys | mt H611A, pH 7.2, 23°C | Homo sapiens | |
0.037 | - |
Fluor de Lys | catalytic domain II, pH 7.2, 23°C | Homo sapiens | |
0.27 | - |
Fluor de Lys | mutant H216A, pH 7.2, 23°C | Homo sapiens | |
0.29 | - |
Fluor de Lys | wild-type, pH 7.2, 23°C | Homo sapiens |