3.5.1.98: histone deacetylase
This is an abbreviated version!
For detailed information about histone deacetylase, go to the full flat file.
Word Map on EC 3.5.1.98
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3.5.1.98
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hdacs
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chromatin
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deacetylases
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trichostatin
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deacetylation
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hydroxamic
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valproic
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saha
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acetyltransferase
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leukemia
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butyrate
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hyperacetylation
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methyltransferase
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vorinostat
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repressor
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lymphoma
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microtubule
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cyclin
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sirtuins
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nucleosome
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t-cells
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transactivation
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caspase
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bcl-2
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metastasis
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myeloid
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proteasome
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hypermethylation
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tumorigenesis
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cardiac
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sirt1
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neurodegenerative
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hematological
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prostate
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demethylation
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antiproliferative
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corepressors
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sirnas
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cpg
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non-histone
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5-aza-2'-deoxycytidine
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valproate
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medicine
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polycomb
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bortezomib
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dnmt3a
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heterochromatin
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creb-binding
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epigenome
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drug development
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coactivator
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relapsed
- 3.5.1.98
- hdacs
- chromatin
- deacetylases
-
trichostatin
-
deacetylation
-
hydroxamic
-
valproic
- saha
- acetyltransferase
- leukemia
- butyrate
-
hyperacetylation
- methyltransferase
- vorinostat
- repressor
- lymphoma
- microtubule
- cyclin
- sirtuins
- nucleosome
- t-cells
-
transactivation
-
caspase
- bcl-2
- metastasis
- myeloid
- proteasome
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hypermethylation
- tumorigenesis
- cardiac
- sirt1
- neurodegenerative
- hematological
- prostate
-
demethylation
-
antiproliferative
-
corepressors
- sirnas
- cpg
-
non-histone
- 5-aza-2'-deoxycytidine
- valproate
- medicine
-
polycomb
- bortezomib
- dnmt3a
- heterochromatin
-
creb-binding
-
epigenome
- drug development
-
coactivator
-
relapsed
Reaction
hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone =
Synonyms
acetyl-lysine deacetylase, AhHDA1, AtHD1, class I acetyl-lysine deacetylase, class I HDAC, class I histone deacetylase, class II Hda1 HDAC, class II histone deacetylase, class IIa HDAC, class IIa histone deacetylase, Clr6, cytoplasmic deacetylase, deacetylase-like amidohydrolase, dRPD3, FB188 HDAH, Glyma.01 g245100, Glyma.04 g000200, Glyma.04 g187000, Glyma.04 g187100, Glyma.05 g012900, Glyma.05 g021400, Glyma.05 g040600, Glyma.05 g192600, Glyma.06 g000100, Glyma.06 g178700, Glyma.11 g000300, Glyma.11 g187800, Glyma.12 g086700, Glyma.12 g188200, Glyma.17 g078000, Glyma.17 g085700, Glyma.17 g120900, Glyma.17 g229600, GmHDA1, GmHDA10, GmHDA11, GmHDA12, GmHDA13, GmHDA14, GmHDA15, GmHDA16, GmHDA17, GmHDA18, GmHDA2, GmHDA3, GmHDA4, GmHDA5, GmHDA6, GmHDA7, GmHDA8, GmHDA9, GmHDAC, HD1B, HD2, HD8, HDA, HDA-1, HDA-2, HDA-3, HDA-4, hda1, HDA15, HDA19, HDA9, HdaA, HDAC, HDAC 11, HDAC 3, HDAC1, HDAC10, HDAC2, HDAC2-1, HDAC2-2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC6p114, HDAC6p131, HDAC7, HDAC8, HDAC9, HDAH, HDLP, HDT1, HDT2, histone deacetylase, histone deacetylase 1, histone deacetylase 10, histone deacetylase 11, histone deacetylase 2, histone deacetylase 3, histone deacetylase 4, histone deacetylase 6, histone deacetylase 7, histone deacetylase 8, histone deacetylase-1, histone deacetylase-7, histone deacetylase-like amidohydrolase, histone deacetylase-like protein, histone deacetylase1, Hos2, HosB, PA3774, pfHDAC-1, RPD3, Set3 complex, Set3C, tubulin deacetylase, zinc-dependent histone deacetylase, Zn(II)-dependent deacetylase, Zn-HDAC
ECTree
3.5.1.98 histone deacetylaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 3.5.1.98 - histone deacetylase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
A0A0R0FIH2, A0A0R0H2W2, A0A0R0JU82, A0A0R0K0I2, I1JB12, I1JZJ1, I1K037, I1LFN1, I1LKU7, I1LTZ2, I1LWR2, I1MTD8, I1MUF8, I1MXC3, K7K0Q1, K7KKZ9, K7KL00, K7KR69
of 5-day-old plants
A0A0R0FIH2, A0A0R0H2W2, A0A0R0JU82, A0A0R0K0I2, I1JB12, I1JZJ1, I1K037, I1LFN1, I1LKU7, I1LTZ2, I1LWR2, I1MTD8, I1MUF8, I1MXC3, K7K0Q1, K7KKZ9, K7KL00, K7KR69
of 5-day-old plants
expressed in gametocytes and mature blood stages of the malaria parasite life cycle
additional information
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atlas on distribution of eleven histone deacetylase isoforms in the brain
expression levels of enzyme isoforms differ during early embryo germination
A0A0R0FIH2, A0A0R0H2W2, A0A0R0JU82, A0A0R0K0I2, I1JB12, I1JZJ1, I1K037, I1LFN1, I1LKU7, I1LTZ2, I1LWR2, I1MTD8, I1MUF8, I1MXC3, K7K0Q1, K7KKZ9, K7KL00, K7KR69
young
A0A0R0FIH2, A0A0R0H2W2, A0A0R0JU82, A0A0R0K0I2, I1JB12, I1JZJ1, I1K037, I1LFN1, I1LKU7, I1LTZ2, I1LWR2, I1MTD8, I1MUF8, I1MXC3, K7K0Q1, K7KKZ9, K7KL00, K7KR69
of 5-day-old plants
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K562 erythroleukemia cells treated with the HbF inducers hemin, trichostatin A, and sodium butanoate have significantly reduced mRNA levels of HDAC9 and its splice variant histone deacetylase-related protein
A0A0R0FIH2, A0A0R0H2W2, A0A0R0JU82, A0A0R0K0I2, I1JB12, I1JZJ1, I1K037, I1LFN1, I1LKU7, I1LTZ2, I1LWR2, I1MTD8, I1MUF8, I1MXC3, K7K0Q1, K7KKZ9, K7KL00, K7KR69
of 14-day-old plants
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in liver, class IIa HDACs HDAC4, 5, and 7, are phosphorylated and excluded from the nucleus by AMPK family kinases. In response to the fasting hormone glucagon, these HDACs are rapidly dephosphorylated and translocated to the nucleus where they associate with the promoters of gluconeogenic enzymes such as G6Pase. In turn, HDAC4/5 recruit HDAC3, which results in the acute transcriptional induction of these genes via deacetylation and activation of FOXO family transcription factors. Loss of class IIa HDACs in murine liver results in inhibition of FOXO target genes and lowers blood glucose, resulting in increased glycogen storage
A0A0R0FIH2, A0A0R0H2W2, A0A0R0JU82, A0A0R0K0I2, I1JB12, I1JZJ1, I1K037, I1LFN1, I1LKU7, I1LTZ2, I1LWR2, I1MTD8, I1MUF8, I1MXC3, K7K0Q1, K7KKZ9, K7KL00, K7KR69
of 5-day-old plants
A0A0R0FIH2, A0A0R0H2W2, A0A0R0JU82, A0A0R0K0I2, I1JB12, I1JZJ1, I1K037, I1LFN1, I1LKU7, I1LTZ2, I1LWR2, I1MTD8, I1MUF8, I1MXC3, K7K0Q1, K7KKZ9, K7KL00, K7KR69
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A0A0R0FIH2, A0A0R0H2W2, A0A0R0JU82, A0A0R0K0I2, I1JB12, I1JZJ1, I1K037, I1LFN1, I1LKU7, I1LTZ2, I1LWR2, I1MTD8, I1MUF8, I1MXC3, K7K0Q1, K7KKZ9, K7KL00, K7KR69
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A0A0R0FIH2, A0A0R0H2W2, A0A0R0JU82, A0A0R0K0I2, I1JB12, I1JZJ1, I1K037, I1LFN1, I1LKU7, I1LTZ2, I1LWR2, I1MTD8, I1MUF8, I1MXC3, K7K0Q1, K7KKZ9, K7KL00, K7KR69
of 14-day-old plants
class I and class IIa histone deacetylases (HDACs) are overexpressed in non-type and basal human bladder cancer (BC) cell lines at the mRNA level, overview
class I and class IIa histone deacetylases (HDACs) are overexpressed in non-type and basal human bladder cancer cell lines at the mRNA level, overview. Basal-squamous bladder cancer (BC) clinical samples are enriched for histone deacetylase (HDAC)4 and HDAC9 expression. Histone deacetylase (HDAC4) and HDAC9 expression co-clusters with basal markers in muscle-invasive bladder cancer
additional information
tissue dependent expression level of enzyme AhHDA1, overview
additional information
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tissue dependent expression level of enzyme AhHDA1, overview
additional information
GmHDACs fall into three major groups previously named RPD3/HDA1, SIR2, and HD2. Real-time quantitative PCR tissue distribution analysis, differential expression across various tissues
additional information
GmHDACs fall into three major groups previously named RPD3/HDA1, SIR2, and HD2. Real-time quantitative PCR tissue distribution analysis, differential expression across various tissues
additional information
GmHDACs fall into three major groups previously named RPD3/HDA1, SIR2, and HD2. Real-time quantitative PCR tissue distribution analysis, differential expression across various tissues
additional information
GmHDACs fall into three major groups previously named RPD3/HDA1, SIR2, and HD2. Real-time quantitative PCR tissue distribution analysis, differential expression across various tissues
additional information
GmHDACs fall into three major groups previously named RPD3/HDA1, SIR2, and HD2. Real-time quantitative PCR tissue distribution analysis, differential expression across various tissues
additional information
GmHDACs fall into three major groups previously named RPD3/HDA1, SIR2, and HD2. Real-time quantitative PCR tissue distribution analysis, differential expression across various tissues
additional information
GmHDACs fall into three major groups previously named RPD3/HDA1, SIR2, and HD2. Real-time quantitative PCR tissue distribution analysis, differential expression across various tissues
additional information
GmHDACs fall into three major groups previously named RPD3/HDA1, SIR2, and HD2. Real-time quantitative PCR tissue distribution analysis, differential expression across various tissues
additional information
GmHDACs fall into three major groups previously named RPD3/HDA1, SIR2, and HD2. Real-time quantitative PCR tissue distribution analysis, differential expression across various tissues
additional information
GmHDACs fall into three major groups previously named RPD3/HDA1, SIR2, and HD2. Real-time quantitative PCR tissue distribution analysis, differential expression across various tissues
additional information
GmHDACs fall into three major groups previously named RPD3/HDA1, SIR2, and HD2. Real-time quantitative PCR tissue distribution analysis, differential expression across various tissues
additional information
GmHDACs fall into three major groups previously named RPD3/HDA1, SIR2, and HD2. Real-time quantitative PCR tissue distribution analysis, differential expression across various tissues
additional information
GmHDACs fall into three major groups previously named RPD3/HDA1, SIR2, and HD2. Real-time quantitative PCR tissue distribution analysis, differential expression across various tissues
additional information
GmHDACs fall into three major groups previously named RPD3/HDA1, SIR2, and HD2. Real-time quantitative PCR tissue distribution analysis, differential expression across various tissues
additional information
GmHDACs fall into three major groups previously named RPD3/HDA1, SIR2, and HD2. Real-time quantitative PCR tissue distribution analysis, differential expression across various tissues
additional information
GmHDACs fall into three major groups previously named RPD3/HDA1, SIR2, and HD2. Real-time quantitative PCR tissue distribution analysis, differential expression across various tissues
additional information
GmHDACs fall into three major groups previously named RPD3/HDA1, SIR2, and HD2. Real-time quantitative PCR tissue distribution analysis, differential expression across various tissues
additional information
GmHDACs fall into three major groups previously named RPD3/HDA1, SIR2, and HD2. Real-time quantitative PCR tissue distribution analysis, differential expression across various tissues
additional information
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GmHDACs fall into three major groups previously named RPD3/HDA1, SIR2, and HD2. Real-time quantitative PCR tissue distribution analysis, differential expression across various tissues
additional information
isoform HDAC10 is expressed in most of the cancer cells examined
additional information
quantitative real-time PCR enzyme expression analysis, high expression of class IIa HDACs in non-type and basal molecular subtype groupings of human BC cells
additional information
quantitative real-time PCR enzyme expression analysis, high expression of class IIa HDACs in non-type and basal molecular subtype groupings of human BC cells
additional information
quantitative real-time PCR enzyme expression analysis, high expression of class IIa HDACs in non-type and basal molecular subtype groupings of human BC cells
additional information
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quantitative real-time PCR enzyme expression analysis, high expression of class IIa HDACs in non-type and basal molecular subtype groupings of human BC cells
