3.5.1.98: histone deacetylase

This is an abbreviated version!
For detailed information about histone deacetylase, go to the full flat file.

Word Map on EC 3.5.1.98

3.5.1.98

hdacs

chromatin

deacetylases

trichostatin

deacetylation

hydroxamic

valproic

saha

acetyltransferase

leukemia

butyrate

hyperacetylation

methyltransferase

vorinostat

repressor

lymphoma

microtubule

cyclin

sirtuins

nucleosome

t-cells

transactivation

caspase

bcl-2

metastasis

myeloid

proteasome

hypermethylation

tumorigenesis

cardiac

sirt1

neurodegenerative

hematological

prostate

demethylation

antiproliferative

corepressors

sirnas

cpg

non-histone

5-aza-2'-deoxycytidine

valproate

medicine

polycomb

bortezomib

dnmt3a

heterochromatin

creb-binding

epigenome

drug development

coactivator

relapsed

Reaction

hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone =

Synonyms

acetyl-lysine deacetylase, AhHDA1, AtHD1, class I acetyl-lysine deacetylase, class I HDAC, class I histone deacetylase, class II Hda1 HDAC, class II histone deacetylase, class IIa HDAC, class IIa histone deacetylase, Clr6, cytoplasmic deacetylase, deacetylase-like amidohydrolase, dRPD3, FB188 HDAH, Glyma.01 g245100, Glyma.04 g000200, Glyma.04 g187000, Glyma.04 g187100, Glyma.05 g012900, Glyma.05 g021400, Glyma.05 g040600, Glyma.05 g192600, Glyma.06 g000100, Glyma.06 g178700, Glyma.11 g000300, Glyma.11 g187800, Glyma.12 g086700, Glyma.12 g188200, Glyma.17 g078000, Glyma.17 g085700, Glyma.17 g120900, Glyma.17 g229600, GmHDA1, GmHDA10, GmHDA11, GmHDA12, GmHDA13, GmHDA14, GmHDA15, GmHDA16, GmHDA17, GmHDA18, GmHDA2, GmHDA3, GmHDA4, GmHDA5, GmHDA6, GmHDA7, GmHDA8, GmHDA9, GmHDAC, HD1B, HD2, HD8, HDA, HDA-1, HDA-2, HDA-3, HDA-4, hda1, HDA15, HDA19, HDA9, HdaA, HDAC, HDAC 11, HDAC 3, HDAC1, HDAC10, HDAC2, HDAC2-1, HDAC2-2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC6p114, HDAC6p131, HDAC7, HDAC8, HDAC9, HDAH, HDLP, HDT1, HDT2, histone deacetylase, histone deacetylase 1, histone deacetylase 10, histone deacetylase 11, histone deacetylase 2, histone deacetylase 3, histone deacetylase 4, histone deacetylase 6, histone deacetylase 7, histone deacetylase 8, histone deacetylase-1, histone deacetylase-7, histone deacetylase-like amidohydrolase, histone deacetylase-like protein, histone deacetylase1, Hos2, HosB, PA3774, pfHDAC-1, RPD3, Set3 complex, Set3C, tubulin deacetylase, zinc-dependent histone deacetylase, Zn(II)-dependent deacetylase, Zn-HDAC

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1 In linear amides

3.5.1.98 histone deacetylase

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Results	in table
5	Activating Compound
22117	AA Sequence
24	Application
1	CAS Registry Number
76	Cloned(Commentary)
3	Cofactor
11	Crystallization (Commentary)
31710	Disease/ Diagnostics
15	Expression
116	General Information
513	IC50 Value
691	Inhibitors
10	kcat/KM [mM/s]
42	Ki Value [mM]
83	KM Value [mM]
76	Localization
37	Metals/Ions
33	Molecular Weight [Da]
42	Natural Substrates/ Products (Substrates)
210	Organism
1	Oxidation Stability
395	PDB ID
16	pH Optimum
18	pI Value
8	Posttranslational Modification
125	Protein Variants
17	Purification (Commentary)
1	Reaction
32	Reaction Type
160	Reference
236	Source Tissue
2	Specific Activity [micromol/min/mg]
178	Substrates and Products (Substrate)
73	Subunits
356	Synonyms
1	Systematic Name
19	Temperature Optimum [°C]
26	Turnover Number [1/s]

KM Value

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KM Value on EC 3.5.1.98 - histone deacetylase

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0.00244 - 0.01646

Ac-DQK(acetyl)-7-amido-4-methylcoumarin

2 entries

0.00228 - 0.0359

Ac-FEK(acetyl)-7-amido-4-methylcoumarin

5 entries

0.0043 - 0.0877

Ac-GGK(acetyl)-7-amido-4-methylcoumarin

5 entries

0.0123 - 0.0666

Ac-GS(PO3)K(acetyl)-7-amido-4-methylcoumarin

5 entries

0.00405 - 0.0241

Ac-GSK(acetyl)-7-amido-4-methylcoumarin

5 entries

0.00069 - 0.108

Ac-IHK(acetyl)-7-amido-4-methylcoumarin

5 entries

0.0124

Ac-ILK(acetyl)-7-amido-4-methylcoumarin