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3.5.1.98: histone deacetylase

This is an abbreviated version!
For detailed information about histone deacetylase, go to the full flat file.

Word Map on EC 3.5.1.98

Reaction

hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone =

Synonyms

acetyl-lysine deacetylase, AhHDA1, AtHD1, class I acetyl-lysine deacetylase, class I HDAC, class I histone deacetylase, class II Hda1 HDAC, class II histone deacetylase, class IIa HDAC, class IIa histone deacetylase, Clr6, cytoplasmic deacetylase, deacetylase-like amidohydrolase, dRPD3, FB188 HDAH, Glyma.01 g245100, Glyma.04 g000200, Glyma.04 g187000, Glyma.04 g187100, Glyma.05 g012900, Glyma.05 g021400, Glyma.05 g040600, Glyma.05 g192600, Glyma.06 g000100, Glyma.06 g178700, Glyma.11 g000300, Glyma.11 g187800, Glyma.12 g086700, Glyma.12 g188200, Glyma.17 g078000, Glyma.17 g085700, Glyma.17 g120900, Glyma.17 g229600, GmHDA1, GmHDA10, GmHDA11, GmHDA12, GmHDA13, GmHDA14, GmHDA15, GmHDA16, GmHDA17, GmHDA18, GmHDA2, GmHDA3, GmHDA4, GmHDA5, GmHDA6, GmHDA7, GmHDA8, GmHDA9, GmHDAC, HD1B, HD2, HD8, HDA, HDA-1, HDA-2, HDA-3, HDA-4, hda1, HDA15, HDA19, HDA9, HdaA, HDAC, HDAC 11, HDAC 3, HDAC1, HDAC10, HDAC2, HDAC2-1, HDAC2-2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC6p114, HDAC6p131, HDAC7, HDAC8, HDAC9, HDAH, HDLP, HDT1, HDT2, histone deacetylase, histone deacetylase 1, histone deacetylase 10, histone deacetylase 11, histone deacetylase 2, histone deacetylase 3, histone deacetylase 4, histone deacetylase 6, histone deacetylase 7, histone deacetylase 8, histone deacetylase-1, histone deacetylase-7, histone deacetylase-like amidohydrolase, histone deacetylase-like protein, histone deacetylase1, Hos2, HosB, PA3774, pfHDAC-1, RPD3, Set3 complex, Set3C, tubulin deacetylase, zinc-dependent histone deacetylase, Zn(II)-dependent deacetylase, Zn-HDAC

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.98 histone deacetylase

Expression

Expression on EC 3.5.1.98 - histone deacetylase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
HDAC1 and HDAC2 protein levels are elevated in chondrocytes from osteoarthritic patients
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hepatocyte growth factor induces HDAC-5 expression in gastric cancer cells. GO6976, a PKC inhibitor, significantly inhibits hepatocyte growth factor-induced HDAC5 expression
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histone deacetylase 1 mRNA in pancreatic cancer tissues are significantly higher than in paracancerous tissues
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isoform HDAC2-1 is significantly induced at 6 and 24 h after spraying of seedlings with 0.1 mM jasmonic acid, isoform HDAC2-1 shows a marked induction at 24 h after 0.1 mM abscisic acid treatment, isoform HDAC2-1 transcript levels show an increase upon treatment with 0.1 mM salicylic acid after 24 h
isoform HDAC2-2 transcript levels decline 6 h after abscisic acid treatment and show no significant difference in 24 h after abscisic acid treatment
K562 erythroleukemia cells treated with the HbF inducers hemin, trichostatin A, and sodium butanoate have significantly reduced mRNA levels of HDAC9 and its splice variant histone deacetylase-related protein
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knockdown of transactive response DNA-binding protein TDP-43 downregulates histone deacetylase 6 mRNA and protein expression and reduces HDAC6 enzyme activity in non-neuronal as well as in neuronal cells
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mutations of the SCF-CDC4 ubiquitin ligase complex suppress cell death by preventing the degradation of Msn2 and Msn4 transcription factors. Accumulation of transcription factors Msn2 and Msn4 leads to the induction of PNC1, which is an activator of the Sir2 histone acetylase
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no conclusions can be drawn for isoform HDAC2-2 after 0.1 mM salicylic acid treatment as transcripts levels increase both in treated and untreated plants at 6 and 24 h, but with no significant differences between them
nuclear HDAC activity is significantly higher in rheumatoid arthritis than in osteoarthritis and normal controls. The mRNA expression of HDAC1 in rheumatoid arthritis synovial tissue is higher than in osteoarthritis and normal controls, and shows positive correlation with tumor necrosis factor-alpha mRNA expression. Stimulation with tumor necrosis factor-alpha (10 ng/ml) significantly increases the nuclear HDAC activity and HDAC1 mRNA expression at 24 h and HDAC1 protein expression at 48 h in synovial fibroblasts from rheumatoid arthritis
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redox signaling, alkylation (carbonylation) of conserved cysteines inactivates class I histone deacetylases 1, 2, and 3. Covalent modification at Cys261 and Cys273 in HDAC1, coincides with attenuation of histone deacetylase activity
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responses of GmHDACs to abscisic acid (ABA) treatment, which is the most important stress-protective phytohormone, differ. Two HD2 family genes (GmHDT2 and GmHDT4) are induced and two RPD3/HDA1 family genes (GmHDA8 and GmHDA16) are markedly suppressed, the expression of five other HDAC genes (GmHDA6, 13, 14, GmSRT2 and GmSRT4) is only slightly modulated. The status of H3K4me2 and H3K4me3 is also modulated by the both cold and heat treatments. High levels of H3K4me2 and low levels of H3K4me3 are observed following cold treatment. The level of H3K4me2 is upregulated in response to heat stress, while this treatment only has a mild effect on H3K4me3 levels
the AhHDA1 encoding gene is upregulated by PEG-induced water limitation and ABA signaling
the hepatic enzyme activity is significantly increased in nuclear and cytoplasmic fractions following partial hepatectomy. Isoform-specific effects of partial hepatectomy on isozyme HDAC mRNA and protein expression, with increased isozyme expression of the class I HDACs, 1 and 8, and class II HDAC4 in regenerating liver. Hepatic expression of (class II) HDAC5 is unchanged after partial hepatectomy, HDAC5 exhibits transient nuclear accumulation in regenerating liver
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the immunohistochemical expression of nuclear HDAC1, HDAC2 and HDAC3 proteins increases stepwise in benign, borderline and malignant tumors of ovarian carcinoma. Cytoplasmic expression of HDAC1, 2 and 3 is significantly increased in carcinomas compared with benign tumors
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