3.4.24.B6: matrix metalloproteinase-20
This is an abbreviated version!
For detailed information about matrix metalloproteinase-20, go to the full flat file.
Word Map on EC 3.4.24.B6
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3.4.24.B6
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amelogenins
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amelogenesis
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tooth
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klk4
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dentin
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imperfecta
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odontoblasts
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ameloblastin
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enamelin
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amelx
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incisor
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sialophosphoprotein
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hypomineralized
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odontogenic
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apatite
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maturation-stage
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fluorosis
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tooth-specific
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fam83h
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kallikrein-4
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kallikrein-related
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hypomaturation
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secretory-stage
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tuftelin
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dentinogenesis
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odontogenesis
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ameloblast-like
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dentin-pulp
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decussating
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dentino-enamel
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tyrosine-rich
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crystallite
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pharmacology
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medicine
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degradation
- 3.4.24.B6
- amelogenins
-
amelogenesis
- tooth
- klk4
- dentin
- imperfecta
- odontoblasts
- ameloblastin
- enamelin
-
amelx
- incisor
- sialophosphoprotein
-
hypomineralized
-
odontogenic
-
apatite
-
maturation-stage
- fluorosis
-
tooth-specific
-
fam83h
- kallikrein-4
-
kallikrein-related
-
hypomaturation
-
secretory-stage
-
tuftelin
-
dentinogenesis
-
odontogenesis
-
ameloblast-like
-
dentin-pulp
-
decussating
-
dentino-enamel
-
tyrosine-rich
-
crystallite
- pharmacology
- medicine
- degradation
Reaction
proteolytic cleavage of ameloblastin =
Synonyms
enamel metalloproteinase, enamel protease, enamelysin, M10.019, matrix metalloproteinase 20, MMP-20, MMP20
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Application on EC 3.4.24.B6 - matrix metalloproteinase-20
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degradation
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MMP-20 processes dentin sialophosphoprotein into smaller subunits in the dentin matrix during odontogenesis
medicine
pharmacology
enzyme is a potential target for selective inhibition and inhibitor design
additional information
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critical role of MMPs in the processing and maturation of the dental matrix
medicine
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first report of a homozygous mutation in the MMP-20 gene, the mutation destroys the splice acceptor sequence at the 3' end of intron 6 encoding the hemopexin domain, the enamel of the subjects' teeth is pigmented, its surface mottled and rough and the enamel layer more opaque than the underlying dentine
medicine
study on the hypothesis that MMP-20 is overexpressed in the dentin-enamel junction, dentin-pulp complex components, and carious dentin of patients that head-and-neck radiotherapy. No apparent damage to the dentin-enamel junction microstructure or other dentin-pulp complex components is observed and no statistically significant differences are detected in MMP-20 expression between the irradiated and control groups
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MMP-20 acts either directly or indirectly to faciliate the removal of maturation-stage enamel proteins
additional information
MMP-20 expression is primarly confined to tooth tissue
additional information
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MMP-20 acts either directly or indirectly to faciliate the removal of maturation-stage enamel proteins
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