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3.4.24.B6: matrix metalloproteinase-20

This is an abbreviated version!
For detailed information about matrix metalloproteinase-20, go to the full flat file.

Word Map on EC 3.4.24.B6

Reaction

proteolytic cleavage of ameloblastin =

Synonyms

enamel metalloproteinase, enamel protease, enamelysin, M10.019, matrix metalloproteinase 20, MMP-20, MMP20

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B6 matrix metalloproteinase-20

Engineering

Engineering on EC 3.4.24.B6 - matrix metalloproteinase-20

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E227A
E235A
-
enzymatically inactive MMP-20
E352K
mutation identified in a family with hypomaturation-type enamel defect. Mutant protein is expressed at a normal level but secreted only minimally with proteolytic function. The homozygous change of glutamic acid to basic lysine in the hemopexin domain is predicted to result in a conformational change in MMP20
H226Q
T130I
mutant protein has reduced activity of MMP20
W34X
the nonsense mutation results in no functional MMP20 during tooth formation
Y180*/T130I
mutation identified in patients with hypomaturation amelogenesis imperfecta. Affected persons exhibit slight yellowish discoloration with reduced transparency
additional information