3.4.24.B6: matrix metalloproteinase-20
This is an abbreviated version!
For detailed information about matrix metalloproteinase-20, go to the full flat file.
Word Map on EC 3.4.24.B6
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3.4.24.B6
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amelogenins
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amelogenesis
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tooth
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klk4
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dentin
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imperfecta
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odontoblasts
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ameloblastin
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enamelin
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amelx
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incisor
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sialophosphoprotein
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hypomineralized
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odontogenic
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apatite
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maturation-stage
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fluorosis
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tooth-specific
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fam83h
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kallikrein-4
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kallikrein-related
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hypomaturation
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secretory-stage
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tuftelin
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dentinogenesis
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odontogenesis
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ameloblast-like
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dentin-pulp
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decussating
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dentino-enamel
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tyrosine-rich
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crystallite
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pharmacology
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medicine
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degradation
- 3.4.24.B6
- amelogenins
-
amelogenesis
- tooth
- klk4
- dentin
- imperfecta
- odontoblasts
- ameloblastin
- enamelin
-
amelx
- incisor
- sialophosphoprotein
-
hypomineralized
-
odontogenic
-
apatite
-
maturation-stage
- fluorosis
-
tooth-specific
-
fam83h
- kallikrein-4
-
kallikrein-related
-
hypomaturation
-
secretory-stage
-
tuftelin
-
dentinogenesis
-
odontogenesis
-
ameloblast-like
-
dentin-pulp
-
decussating
-
dentino-enamel
-
tyrosine-rich
-
crystallite
- pharmacology
- medicine
- degradation
Reaction
proteolytic cleavage of ameloblastin =
Synonyms
enamel metalloproteinase, enamel protease, enamelysin, M10.019, matrix metalloproteinase 20, MMP-20, MMP20
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Expression
Expression on EC 3.4.24.B6 - matrix metalloproteinase-20
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increased expression of ODAM and Runx2 augments MMP-20 expression, and both TGF-beta1 and BMP-2 up-regulate Runx2 expression. TGF-beta1 promotes MMP-20 expression in ameloblasts
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loss and siRNA-mediated silencing of Runx2 in ameloblast-lineage cells decreases ODAM expression, resulting in downregulation of MMP-20 expression
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Mmp20 expression levels must be within a specific range for normal enamel development to occur. Creation of a normally thick enamel layer may occur over a wider range of Mmp20 expression levels, but acquisition of normal enamel hardness has a narrower range
transforming growth factor-beta1, TGF-beta1, prominently induces MMP20 expression in ameloblast-lineage cells
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