3.4.24.B6: matrix metalloproteinase-20
This is an abbreviated version!
For detailed information about matrix metalloproteinase-20, go to the full flat file.
Word Map on EC 3.4.24.B6
-
3.4.24.B6
-
amelogenins
-
amelogenesis
-
tooth
-
klk4
-
dentin
-
imperfecta
-
odontoblasts
-
ameloblastin
-
enamelin
-
amelx
-
incisor
-
sialophosphoprotein
-
hypomineralized
-
odontogenic
-
apatite
-
maturation-stage
-
fluorosis
-
tooth-specific
-
fam83h
-
kallikrein-4
-
kallikrein-related
-
hypomaturation
-
secretory-stage
-
tuftelin
-
dentinogenesis
-
odontogenesis
-
ameloblast-like
-
dentin-pulp
-
decussating
-
dentino-enamel
-
tyrosine-rich
-
crystallite
-
pharmacology
-
medicine
-
degradation
- 3.4.24.B6
- amelogenins
-
amelogenesis
- tooth
- klk4
- dentin
- imperfecta
- odontoblasts
- ameloblastin
- enamelin
-
amelx
- incisor
- sialophosphoprotein
-
hypomineralized
-
odontogenic
-
apatite
-
maturation-stage
- fluorosis
-
tooth-specific
-
fam83h
- kallikrein-4
-
kallikrein-related
-
hypomaturation
-
secretory-stage
-
tuftelin
-
dentinogenesis
-
odontogenesis
-
ameloblast-like
-
dentin-pulp
-
decussating
-
dentino-enamel
-
tyrosine-rich
-
crystallite
- pharmacology
- medicine
- degradation
Reaction
proteolytic cleavage of ameloblastin =
Synonyms
enamel metalloproteinase, enamel protease, enamelysin, M10.019, matrix metalloproteinase 20, MMP-20, MMP20
ECTree
Advanced search results
Natural Substrates Products
Natural Substrates Products on EC 3.4.24.B6 - matrix metalloproteinase-20
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
ameloblastin + H2O
?
MMP-20 processes ameloblastin during the secretory stage of amelogenesis, cleaves glycosylated recombinant porcine ameloblastin after Pro2, Gln130, Gln139, Arg170, and Ala222. MMP-20 generates the 23-kDa ameloblastin starting at Tyr223, as well as the 17-kDa (Val1-Arg170) and 15-kDa (Val1-Gln130) ameloblastin cleavage products that concentrate in the sheath space during the secretory stage
-
-
?
ameloblastin + H2O
ameloblastin fragments
-
N-terminal ameloblastin cleavage products of 13, 15, and 17 kDa accumulate in the sheath space throughout the enamel layer
-
-
?
cartilage oligomeric matrix protein + H2O
60 kDa protein
100 kDa protein substrate
-
?
enamel protein + H2O
?
MMP-20 is secreted along with enamel proteins by secretory stage ameloblasts into the enamel matrix of developing teeth. Enamel protein cleavage products accumulate in the space between the crystal ribbons, helping to support them. MMP-20 steadily cleaves accumulated enamel proteins, so their concentration decreases with depth. The principle functions of MMP-20 in dental enamel formation is to facilitate the orderly replacement of organic matrix with mineral, generating an enamel layer that is harder, less porous, and unstained by retained enamel proteins
-
-
?
?
amelogenin with a proline 41 to threonine mutation is hydrolyzed at a lower rate by matrix metalloproteinase 20 (MMP20), resulting in an inherited tooth enamel defect, amelogenesis
-
-
?
amelogenin + H2O
?
-
MMP-20 is involved in amelogenin processing and degradation
-
-
?
amelogenin + H2O
?
-
amelogenin constitutes more than 90% of enamel extracellular matrix proteins in secretory-stage enamel
-
-
?
amelogenin + H2O
?
-
most of the secreted substrate is cleaved after Ser148 to generate the 20000 Da amelogenin (Met1-Ser148), which in turn is cleaved after Trp45 to yield the tyrosine-rich amelogenin polypeptide (Met1-Trp45) and the 13000 Da amelogenin (Leu46-Ser148)
-
-
?
?
-
degradation of various components of the extracellular matrix during tooth development and pathological conditions
-
?
additional information
?
-
-
degradation of various components of the extracellular matrix during tooth development and pathological conditions
-
?
additional information
?
-
-
recombinant Mmp-20 is self-activated by its incubation in 4-aminophenylmercuric acetate in 10 mM CaCl2 for 24 h
-
-
?