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3.4.24.B6: matrix metalloproteinase-20

This is an abbreviated version!
For detailed information about matrix metalloproteinase-20, go to the full flat file.

Word Map on EC 3.4.24.B6

Reaction

proteolytic cleavage of ameloblastin =

Synonyms

enamel metalloproteinase, enamel protease, enamelysin, M10.019, matrix metalloproteinase 20, MMP-20, MMP20

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B6 matrix metalloproteinase-20

Natural Substrates Products

Natural Substrates Products on EC 3.4.24.B6 - matrix metalloproteinase-20

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
aggrecan + H2O
?
show the reaction diagram
cleavage site is Asn341-Phe342
-
?
ameloblastin + H2O
?
show the reaction diagram
MMP-20 processes ameloblastin during the secretory stage of amelogenesis, cleaves glycosylated recombinant porcine ameloblastin after Pro2, Gln130, Gln139, Arg170, and Ala222. MMP-20 generates the 23-kDa ameloblastin starting at Tyr223, as well as the 17-kDa (Val1-Arg170) and 15-kDa (Val1-Gln130) ameloblastin cleavage products that concentrate in the sheath space during the secretory stage
-
-
?
ameloblastin + H2O
ameloblastin fragments
show the reaction diagram
-
N-terminal ameloblastin cleavage products of 13, 15, and 17 kDa accumulate in the sheath space throughout the enamel layer
-
-
?
amelogenin + H2O
?
show the reaction diagram
amelogenin + H2O
amelogenin fragments
show the reaction diagram
-
-
-
-
?
amelogenin + H2O
fragments of amelogenin
show the reaction diagram
-
-
-
-
?
amylogenin + H2O
?
show the reaction diagram
cartilage oligomeric matrix protein + H2O
60 kDa protein
show the reaction diagram
100 kDa protein substrate
-
?
E-cadherin + H2O
?
show the reaction diagram
-
MMP20 cleaves the extracellular domain of E-cadherin
-
-
?
enamel protein + H2O
?
show the reaction diagram
MMP-20 is secreted along with enamel proteins by secretory stage ameloblasts into the enamel matrix of developing teeth. Enamel protein cleavage products accumulate in the space between the crystal ribbons, helping to support them. MMP-20 steadily cleaves accumulated enamel proteins, so their concentration decreases with depth. The principle functions of MMP-20 in dental enamel formation is to facilitate the orderly replacement of organic matrix with mineral, generating an enamel layer that is harder, less porous, and unstained by retained enamel proteins
-
-
?
enamelin + H2O
enamelin fragments
show the reaction diagram
-
-
-
-
?
proteins + H2O
peptides
show the reaction diagram
additional information
?
-