3.4.24.B6: matrix metalloproteinase-20
This is an abbreviated version!
For detailed information about matrix metalloproteinase-20, go to the full flat file.
Word Map on EC 3.4.24.B6
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3.4.24.B6
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amelogenins
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amelogenesis
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tooth
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klk4
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dentin
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imperfecta
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odontoblasts
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ameloblastin
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enamelin
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amelx
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incisor
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sialophosphoprotein
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hypomineralized
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odontogenic
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apatite
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maturation-stage
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fluorosis
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tooth-specific
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fam83h
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kallikrein-4
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kallikrein-related
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hypomaturation
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secretory-stage
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tuftelin
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dentinogenesis
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odontogenesis
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ameloblast-like
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dentin-pulp
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decussating
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dentino-enamel
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tyrosine-rich
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crystallite
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pharmacology
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medicine
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degradation
- 3.4.24.B6
- amelogenins
-
amelogenesis
- tooth
- klk4
- dentin
- imperfecta
- odontoblasts
- ameloblastin
- enamelin
-
amelx
- incisor
- sialophosphoprotein
-
hypomineralized
-
odontogenic
-
apatite
-
maturation-stage
- fluorosis
-
tooth-specific
-
fam83h
- kallikrein-4
-
kallikrein-related
-
hypomaturation
-
secretory-stage
-
tuftelin
-
dentinogenesis
-
odontogenesis
-
ameloblast-like
-
dentin-pulp
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decussating
-
dentino-enamel
-
tyrosine-rich
-
crystallite
- pharmacology
- medicine
- degradation
Reaction
proteolytic cleavage of ameloblastin =
Synonyms
enamel metalloproteinase, enamel protease, enamelysin, M10.019, matrix metalloproteinase 20, MMP-20, MMP20
ECTree
3.4.24.B6 matrix metalloproteinase-20Advanced search results
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results (Source Tissue
Source Tissue on EC 3.4.24.B6 - matrix metalloproteinase-20
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
minute quantities, 5000fold lower than in 4-day-old first molar tooth buds
presence of MMP20 at mRNA and protein level. MMP20 is coexpressed with dentin sialophosphoprotein DSPP. The MMP20-DSPP interaction is very intense and specific, and precludes MMP20 from interacting with the other members of the small integrin-binding ligand N-linked glycoproteins
only in jaw containing the developing tooth buds appreciable levels of the enzyme
additional information
MMP-20 is secreted along with enamel proteins by secretory stage ameloblasts into the enamel matrix of developing teeth
detectable only in ameloblasts and odontoblasts of developing teeth
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Enamel formation progresses through a secretory and a maturation stage, MMP-20 is expressed during the secretory and early-maturation stages
MMP20 is expressed in all segments of the nephron with marked intensity in the proximal and distal tubules, and is absent in the glomeruli. MMP20 is coexpressed with dentin sialophosphoprotein in the proximal, distal, and collecting tubules, and in mixed renal cells
MMP20 is expressed in all segments of the nephron with marked intensity in the proximal and distal tubules, and is absent in the glomeruli. MMP20 is coexpressed with dentin sialophosphoprotein in the proximal, distal, and collecting tubules, and in mixed renal cells
detectable only in ameloblasts and odontoblasts of developing teeth
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at the later secretory stage mostly in the outer part of the forming enamel, weakly in inner forming enamel associated with the holes located near the DEJ
additional information
not detected in bladder, eye, spleen, stomach and thymus
additional information
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not detected in bladder, eye, spleen, stomach and thymus
additional information
not observed in alveolar bone or in other areas of the dental sac or pulp. Enamelysin mRNA is not detected in the enamel-free zone
additional information
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not observed in alveolar bone or in other areas of the dental sac or pulp. Enamelysin mRNA is not detected in the enamel-free zone
additional information
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in the presecretory stage in the apical poles of ameloblasts but not in non-mineralized dentin, basement membrane, matrix vesicles or in collagen fibrils, at the later secretory stage mostly in the secretory ameloblasts, in the stratum intermedium, and also in some pulp cells, in the stellate reticulum and in predentin but not in mantle dentin, dentin, metadentin and predentin
