3.4.24.82: ADAMTS-4 endopeptidase

This is an abbreviated version!
For detailed information about ADAMTS-4 endopeptidase, go to the full flat file.

Reaction

Glutamyl endopeptidase; bonds cleaved include -Thr-Glu-Gly-Glu373-/-Ala-Arg-Gly-Ser- in the interglobular domain of mammalian aggrecan =

Synonyms

a disintegrin and metalloprotease with thrombospondin motifs-4, a disintegrin and metalloproteinase with thrombospondin motif, a disintegrin and metalloproteinase with thrombospondin motifs 4, a disintegrin and metalloproteinase with thrombospondin motifs-4, a disintegrin and metalloproteinase with thrombospondin-1-like motifs, a disintegrin-like and metalloproteinase with thrombospondin motifs-4, a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs-4, ADAMTS 4, ADAMTS-1, ADAMTS-4, ADAMTS-4 [a disintegrin and metalloproteinase with thrombospondin motifs-4], ADAMTS-4-2, ADAMTS4, agg-1, aggrecanase, aggrecanase 1, aggrecanase-1, disintegrin and metalloproteinase with thrombospondin motif 4, TS-4

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.82 ADAMTS-4 endopeptidase

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Results	in table
48	Activating Compound
19	AA Sequence
17	Application
1	CAS Registry Number
28	Cloned(Commentary)
2	Crystallization (Commentary)
895	Disease/ Diagnostics
3	Expression
12	General Information
130	IC50 Value
215	Inhibitors
29	Ki Value [mM]
9	KM Value [mM]
5	Localization
4	Metals/Ions
22	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
105	Organism
15	PDB ID
8	pH Optimum
1	pH Range
2	Posttranslational Modification
6	Protein Variants
20	Purification (Commentary)
1	Reaction
1	Reaction Type
96	Reference
101	Source Tissue
2	Specific Activity [micromol/min/mg]
127	Substrates and Products (Substrate)
7	Subunits
131	Synonyms
10	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.24.82 - ADAMTS-4 endopeptidase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

aggrecan + H2O

?

3 entries

aggrecan + H2O

fragments of aggrecan

5 entries

amyloid beta 1-38 peptide + H2O

amyloid beta 4-38 fragment + amyloid beta 12-38 fragment + ?

Mus musculus

Q8BNJ2

the enzyme cleaves after Glu4 and Glu12

752411

-

-

?

amyloid beta 1-40 peptide + H2O

amyloid beta 4-40 fragment + amyloid beta 12-40 fragment

Mus musculus

Q8BNJ2

the enzyme cleaves after Glu4 and Glu12

752411

-

-

?

amyloid beta 1-42 peptide + H2O

amyloid beta 4-42 fragment + amyloid beta 12-42 fragment + ?

Mus musculus

Q8BNJ2

the enzyme cleaves after Glu4 and Glu12

752411

-

-

?

brevican + H2O

fragments of brevican

Homo sapiens

-

-

720093

-

-

?

carboxymethylated transferrin + H2O

?

Homo sapiens

-

-

720093

-

-

?

cartilage oligomeric matrix protein + H2O

?

Homo sapiens

-

-

720093

-

-

?

decorin + H2O

?

Homo sapiens

-

-

720093

-

-

?

fibromodulin + H2O

?

Homo sapiens

-

-

720093

-

-

?

poly-ADP ribose polymerase-1 + H2O

?

Mus musculus

Q8BNJ2

-

755457

-

-

?

versican + H2O

?

Mus musculus

Q8BNJ2

-

755457

-

-

?

versican V1 + H2O

fragments of versican V1

Homo sapiens

-

-

720093

-

-

?

aggrecan + H2O

?

Homo sapiens

-

-

695958

-

-

?

aggrecan + H2O

?

Homo sapiens

O75173

-

754392, 754633, 754958

-

-

?

aggrecan + H2O

?

Homo sapiens

-

ADAMTS-4 and ADAMTS-5 are the proteases responsible for the endogenous aggrecanase activity observed in IL-1beta stimulated bovine cartilage

709044

-

-

?

aggrecan + H2O

fragments of aggrecan

Bos taurus

-

-

638952, 638955

-

-

?

aggrecan + H2O

fragments of aggrecan

Homo sapiens

-

-

720093

-

-

?

aggrecan + H2O

fragments of aggrecan

Homo sapiens

-

aggrecanase-1 is responsible for the cleavage of aggrecan interglobular domain at the Glu373-Ala374 peptide bond

719063

-

-

?

aggrecan + H2O

fragments of aggrecan

Mus musculus

-

cleavage at the Glu373-Ala374 site

678287

-

-

?

aggrecan + H2O

fragments of aggrecan

Rattus norvegicus

-

-

638952

-

-

?