Literature summary for 3.4.24.82 extracted from

Wittwer, A.J.; Hills, R.L.; Keith, R.H.; Munie, G.E.; Arner, E.C.; Anglin, C.P.; Malfait, A.M.; Tortorella, M.D.
Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (aggrecanase 1) (2007), Biochemistry, 46, 6393-6401.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Sf9 cells	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
QEYKAHHSYKLMS	-	Mus musculus
SC81956	demonstrates noncompetitive inhibition kinetics	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
aggrecan + H2O	Mus musculus	cleavage at the Glu373-Ala374 site	fragments of aggrecan	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
aggrecan + H2O	cleavage at the Glu373-Ala374 site	Mus musculus	fragments of aggrecan	-	?
K(6-(fluorescein-5-carboxamido)-hexanoic acid)-DVQEFRGVTAVIR-C(QSY9)-KGK + H2O	-	Mus musculus	C(QSY9) + KGK + K(6-(fluorescein-5-carboxamido)-hexanoic acid)-DVQEFRGVTAVIR	-	?

Synonyms

Synonyms	Comment	Organism
a disintegrin and metalloproteinase with thrombospondin motifs-4	-	Mus musculus
ADAMTS-4	-	Mus musculus
aggrecanase 1	-	Mus musculus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0000228	-	SC81956	at 37°C	Mus musculus
0.026	-	QEYKAHHSYKLMS	at 37°C	Mus musculus

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Release 2023.1 (January 2023)