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Literature summary for 3.4.24.82 extracted from

  • Walter, S.; Jumpertz, T.; Huettenrauch, M.; Ogorek, I.; Gerber, H.; Storck, S.E.; Zampar, S.; Dimitrov, M.; Lehmann, S.; Lepka, K.; Berndt, C.; Wiltfang, J.; Becker-Pauly, C.; Beher, D.; Pietrzik, C.U.; Fraering, P.C.; Wirths, O.; Weggen, S.
    The metalloprotease ADAMTS4 generates N-truncated A?4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimers disease (2019), Acta Neuropathol., 137, 239-257 .
    View publication on PubMed
Search for more literature for 3.4.24.82

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid beta 1-38 peptide + H2O Mus musculus the enzyme cleaves after Glu4 and Glu12 amyloid beta 4-38 fragment + amyloid beta 12-38 fragment + ?
-
 ?
amyloid beta 1-40 peptide + H2O Mus musculus the enzyme cleaves after Glu4 and Glu12 amyloid beta 4-40 fragment + amyloid beta 12-40 fragment
-
 ?
amyloid beta 1-42 peptide + H2O Mus musculus the enzyme cleaves after Glu4 and Glu12 amyloid beta 4-42 fragment + amyloid beta 12-42 fragment + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8BNJ2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
oligodendrocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid beta 1-38 peptide + H2O the enzyme cleaves after Glu4 and Glu12 Mus musculus amyloid beta 4-38 fragment + amyloid beta 12-38 fragment + ?
-
 ?
amyloid beta 1-40 peptide + H2O the enzyme cleaves after Glu4 and Glu12 Mus musculus amyloid beta 4-40 fragment + amyloid beta 12-40 fragment
-
 ?
amyloid beta 1-42 peptide + H2O the enzyme cleaves after Glu4 and Glu12 Mus musculus amyloid beta 4-42 fragment + amyloid beta 12-42 fragment + ?
-
 ?

Synonyms

Synonyms Comment Organism
a disintegrin and metalloproteinase with thrombospondin motifs 4
-
 Mus musculus
ADAMTS4
-
 Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease Mus musculus