3.4.24.82: ADAMTS-4 endopeptidase

This is an abbreviated version!
For detailed information about ADAMTS-4 endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.82

3.4.24.82

cartilage

metalloproteinase

thrombospondin

disintegrin

osteoarthritis

chondrocytes

collagen

adamts-5

articular

joint

proteoglycans

degeneration

disc

mmp-1

knee

intervertebral

interleukin-1

explants

tnf

synovial

versican

timp-3

degener

pulposus

glycosaminoglycans

chondroitin

adams

aggrecanase-2

neoepitope

motifs-4

arthritic

disintegrin-like

chondroprotective

intra-articular

aggrecanolysis

meniscus

brevican

subchondral

matrix-degrading

interglobular

col2a1

thrombospondin-like

aggrecanase-mediated

cartilage-degrading

fibromodulin

fibrosus

il-1-induced

safranin

medicine

nitege

degradation

anti-catabolic

Reaction

Glutamyl endopeptidase; bonds cleaved include -Thr-Glu-Gly-Glu373-/-Ala-Arg-Gly-Ser- in the interglobular domain of mammalian aggrecan =

Synonyms

a disintegrin and metalloprotease with thrombospondin motifs-4, a disintegrin and metalloproteinase with thrombospondin motif, a disintegrin and metalloproteinase with thrombospondin motifs 4, a disintegrin and metalloproteinase with thrombospondin motifs-4, a disintegrin and metalloproteinase with thrombospondin-1-like motifs, a disintegrin-like and metalloproteinase with thrombospondin motifs-4, a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs-4, ADAMTS 4, ADAMTS-1, ADAMTS-4, ADAMTS-4 [a disintegrin and metalloproteinase with thrombospondin motifs-4], ADAMTS-4-2, ADAMTS4, agg-1, aggrecanase, aggrecanase 1, aggrecanase-1, disintegrin and metalloproteinase with thrombospondin motif 4, TS-4

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.82 ADAMTS-4 endopeptidase

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Results	in table
48	Activating Compound
19	AA Sequence
17	Application
1	CAS Registry Number
28	Cloned(Commentary)
2	Crystallization (Commentary)
895	Disease/ Diagnostics
3	Expression
12	General Information
130	IC50 Value
215	Inhibitors
29	Ki Value [mM]
9	KM Value [mM]
5	Localization
4	Metals/Ions
22	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
105	Organism
15	PDB ID
8	pH Optimum
1	pH Range
2	Posttranslational Modification
6	Protein Variants
20	Purification (Commentary)
1	Reaction
1	Reaction Type
96	Reference
101	Source Tissue
2	Specific Activity [micromol/min/mg]
127	Substrates and Products (Substrate)
7	Subunits
131	Synonyms
10	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.4.24.82 - ADAMTS-4 endopeptidase

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36000

Sus scrofa

SDS-PAGE, small amount of ADAMTS4 found in porcupine articular cartilage without interleukin-1alpha treatment

669206

40000

3 entries

42000

Homo sapiens

SDS-PAGE, active enzyme

667796

46000

Sus scrofa

SDS-PAGE, primary form of ADAMTS4 in the interleukine-1alpha-treated porcupine articular cartilage

669206

50000

Homo sapiens

SDS-PAGE, after incubation with alpha1-antitrypsin suggesting that there ADAMTS-4 has almost no proteolytic activity

667796

53000

Homo sapiens

SDS-PAGE, activated ADAMTS-4

62000

x * 62000, SDS-PAGE

64000

68000

69000

x * 69000, recombinant aggrecanase-1, SDS-PAGE

70000

73000

SDS-PAGE

75000

98000

SDS-PAGE, proform of ADAMTS-4

667320